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485842-97-5,MFCD05260695
Catalog No.:AA00DLTH

485842-97-5 | PMX 464

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Purity
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5mg
>99%
1 week  
$347.00   $243.00
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25mg
>99%
1 week  
$990.00   $693.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DLTH
Chemical Name:
PMX 464
CAS Number:
485842-97-5
Molecular Formula:
C13H9NO2S
Molecular Weight:
243.2811
MDL Number:
MFCD05260695
SMILES:
O=C1C=CC(C=C1)(O)c1nc2c(s1)cccc2
Properties
Computed Properties
 
Complexity:
375  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
2  

Literature

Title: Quinol derivatives as potential trypanocidal agents.

Journal: Bioorganic & medicinal chemistry 20120215

Title: Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.

Journal: The Journal of biological chemistry 20110311

Title: Structure of Mycobacterium tuberculosis thioredoxin in complex with quinol inhibitor PMX464.

Journal: Protein science : a publication of the Protein Society 20110101

Title: Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2).

Journal: European journal of pharmacology 20100925

Title: Hydrolysis and photolysis of 4-Acetoxy-4-(benzothiazol-2-yl)-2,5-cyclohexadien-1-one, a model anti-tumor quinol ester.

Journal: The Journal of organic chemistry 20090619

Title: Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions.

Journal: Journal of medicinal chemistry 20070405

Title: Antitumor quinols: role of glutathione in modulating quinol-induced apoptosis and identification of putative cellular protein targets.

Journal: Biochemical and biophysical research communications 20060721

Title: Elucidation of thioredoxin as a molecular target for antitumor quinols.

Journal: Cancer research 20050501

Title: Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study.

Journal: British journal of cancer 20050131

Title: Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.

Journal: Journal of medicinal chemistry 20050127

Title: 4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.

Journal: Journal of medicinal chemistry 20030213

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