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51753-57-2,MFCD00423674
Catalog No.:AA00DQRI

51753-57-2 | 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one

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  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DQRI
Chemical Name:
7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one
CAS Number:
51753-57-2
Molecular Formula:
C15H10BrClN2O
Molecular Weight:
349.6097
MDL Number:
MFCD00423674
SMILES:
O=C1CN=C(c2c(N1)ccc(c2)Br)c1ccccc1Cl
Properties
Computed Properties
 
Complexity:
415  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
3.3  

Literature

Title: New uncontrolled benzodiazepine, phenazepam, emerging drug of abuse.

Journal: Innovations in clinical neuroscience 20120901

Title: Effects of physicochemical forms of phenazepam and Panavir on their action at ultra-low doses.

Journal: Bulletin of experimental biology and medicine 20120801

Title: Phenazepam abuse in Finland: findings from apprehended drivers, post-mortem cases and police confiscations.

Journal: Forensic science international 20120710

Title: Phenazepam and cannabinomimetics sold as herbal highs in New Zealand.

Journal: Drug testing and analysis 20120601

Title: Phenazepam abuse in the UK: an emerging problem causing serious adverse health problems, including death.

Journal: Human psychopharmacology 20120501

Title: Phenazepam: the drug that came in from the cold.

Journal: Journal of forensic and legal medicine 20120401

Title: Reactivity of commercial benzodiazepine immunoassays to phenazepam.

Journal: Journal of analytical toxicology 20120401

Title: Detection and validated quantification of 21 benzodiazepines and 3 'z-drugs' in human hair by LC-MS/MS.

Journal: Forensic science international 20120210

Title: Determination of benzodiazepines in ante-mortem and post-mortem whole blood by solid-supported liquid-liquid extraction and UPLC-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120201

Title: [The patterns of interzonal EEG relations and its relationship with the subjective assessment of single-dose action of phenazepam in patients with anxiety disorders].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101

Title: [Experimental justification of possible mechanisms of action of low intensity electromagnetic radiation (EMR) on animals' behavior].

Journal: Radiatsionnaia biologiia, radioecologiia 20120101

Title: Anxiolytic and antidepressant effects of aqueous tincture of the aerial part of Myosotis arvensis.

Journal: Bulletin of experimental biology and medicine 20110901

Title: Phenazepam is currently being misused in the UK.

Journal: BMJ (Clinical research ed.) 20110705

Title: [Ischemic heart disease in elderly patients of behavioral type A (psychosocial and clinic functional changes, possibilities for correction)].

Journal: Advances in gerontology = Uspekhi gerontologii 20110101

Title: [Effect of phenazepam in various medicinal forms on psychophysical state of patients with anxiety disorders].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: [Effect of afobazole on the psychophysiological state of healthy volunteers].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: [Effect of GB-115 dipeptide on anxiety in rats with model benzodiazepine withdrawal syndrome].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: β-Polymorph of phenazepam: a powder study.

Journal: Acta crystallographica. Section E, Structure reports online 20101001

Title: Fatality involving the ingestion of phenazepam and poppy seed tea.

Journal: Journal of analytical toxicology 20101001

Title: [Pharmacologic correction of psycho-emotional status of patients with thyroid nodules in the preoperative period].

Journal: Voprosy onkologii 20100101

Title: The use of tenoten and tenoten (pediatric formulation) as a drug for premedication in adults and children during outpatients dentist visit.

Journal: Bulletin of experimental biology and medicine 20090801

Title: Tenoten in the therapy of patients with moderate cognitive impairment.

Journal: Bulletin of experimental biology and medicine 20090801

Title: [Abuse of phenazepam--new phenomenon in Sweden. Benzodiazepine derivative from Russia caused severe intoxication].

Journal: Lakartidningen 20090201

Title: [Therapeutic effect and pharmacokinetics of transdermal phenazepam preparation in patients with different anxiety disorders].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20090101

Title: Direct analysis of illicit drugs by desorption atmospheric pressure photoionization.

Journal: Rapid communications in mass spectrometry : RCM 20080401

Title: [Discriminative stimulus properties of phenazepam and lorazepam: specificity and role of GABA A receptors].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20080101

Title: [Predictors of the efficacy of methods for psychocorrection in patients with irritable bowel syndrome and constipation].

Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20080101

Title: Study of bipathic effect of phenazepam.

Journal: Bulletin of experimental biology and medicine 20071001

Title: [Application of extraction freezing for analysis of 1,4-benzodiazepines in urine].

Journal: Sudebno-meditsinskaia ekspertiza 20070101

Title: [Effect of caffeine and phenazepam on the quantitative parameters of the EEG and ultraslow electrical processes in the brain].

Journal: Fiziologiia cheloveka 20070101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Free radical oxidation in rat brain during chronic stress and pharmacological regulation of this process.

Journal: Bulletin of experimental biology and medicine 20051001

Title: [Thanatogenesis in poisoning with psychopharmaceuticals].

Journal: Sudebno-meditsinskaia ekspertiza 20050101

Title: [Preoperative psychopharmacological correction in women with focal breast diseases].

Journal: Anesteziologiia i reanimatologiia 20050101

Title: [Methodological bases of early psychosocial rehabilitation of poststroke patients in neurological hospital].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [A comparative study of the development of drug differentiation between mexidol and phenazepam].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20050101

Title: [Characteristics of clinical and pharmacological efficacy of tranquilizers and antidepressants in patients with ischemic heart disease and type A behavior].

Journal: Kardiologiia 20040101

Title: [Experimental pharmacokinetics of phenazepam during transdermal administration of the therapeutic phenaperkuten system].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20040101

Title: [Stress-induced alteration of the antiaggressive effect of anxiolytics].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20040101

Title: Effect of lauric acid on transdermal penetration of phenazepam in vivo.

Journal: Bulletin of experimental biology and medicine 20031201

Title: [Clinical picture and treatment of agoraphobia with panic disorder].

Journal: Voenno-meditsinskii zhurnal 20030601

Title: The influence of anticonvulsant and antioxidant drugs on nitric oxide level and lipid peroxidation in the rat brain during penthylenetetrazole-induced epileptiform model seizures.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20030501

Title: [Effect of phenazepam metabolite, 2-amino-5-bromo-2'-chlorobenzophenone, on glycine and glutamate NMDA receptors of rat hippocampal pyramidal neurones].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20030101

Title: [Pharmacokinetics and efficacy of phenazepam after transdermal and enteral administration in rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20030101

Title: [Effect of naloxone on the activity of Cl(-)-activated Mg(2+)-ATPase from plasma membrane fraction of the common bream brain (Abramis brama L.) in the presence of GABAa-ergic substances].

Journal: Izvestiia Akademii nauk. Seriia biologicheskaia 20030101

Title: [Screening method for compounds acting at super low concentrations].

Journal: Radiatsionnaia biologiia, radioecologiia 20030101

Title: [Effects of psychotropic drugs of different classes injected in super small doses].

Journal: Radiatsionnaia biologiia, radioecologiia 20030101

Title: [The influence of pharmacologically active substances of different classes at ultra low doses on lipid peroxidation in brain cell membranes and activity of acetylcholinesterase in vivo and in vitro].

Journal: Radiatsionnaia biologiia, radioecologiia 20030101

Title: Effects of phenazepam in ultralow doses on bioelectric activity of the brain and behavior of rats in various models of anxiety.

Journal: Bulletin of experimental biology and medicine 20030101

Title: Pharmacological activity of phenazepam and flunitrazepam in ultralow doses.

Journal: Bulletin of experimental biology and medicine 20030101

Title: Phenazepam in therapeutic and ultralow doses in vitro modulates the content of lipid peroxidation products and acetylcholinesterase activity in membrane fraction from mouse brain.

Journal: Bulletin of experimental biology and medicine 20030101

Title: Psychotropic activity of the antialcohol preparation Proproten-100.

Journal: Bulletin of experimental biology and medicine 20030101

Title: Biokinetics of transdermal 3-hydroxyphenazepam.

Journal: Bulletin of experimental biology and medicine 20020901

Title: Effect of activators and blockers of ligand-regulated ion channels on the activity of the Cl-stimulated Mg2+-ATPase of the plasma membrane fraction from bream (Abramis brama L.) brain.

Journal: Biochemistry. Biokhimiia 20020201

Title: Modulation of GABAA receptor-mediated currents by phenazepam and its metabolites.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010701

Title: [Predicting individual reactions to emotional stress and benzodiazepine tranquilizers].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101

Title: [Using computer sound cards in electrophysiological data processing].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101

Title: [Is it possible to predict individual stress resistance by evaluating low dose benzodiazepine effect in modeled emotional stress].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101

Title: [Pharmacological analysis of memory disorders of different origins].

Journal: Biulleten' eksperimental'noi biologii i meditsiny 19890601

Title: Effect of nicergoline on learning and memory.

Journal: Methods and findings in experimental and clinical pharmacology 19880701

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Tags:51753-57-2 Molecular Formula|51753-57-2 MDL|51753-57-2 SMILES|51753-57-2 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one