Home Amines 62-32-8
62-32-8,MFCD00035074
Catalog No.:AA00E8MD

62-32-8 | N-Methyldopamine HCl

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1g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E8MD
Chemical Name:
N-Methyldopamine HCl
CAS Number:
62-32-8
Molecular Formula:
C9H14ClNO2
Molecular Weight:
203.6660
MDL Number:
MFCD00035074
SMILES:
CNCCc1ccc(c(c1)O)O.Cl
NSC Number:
294897
Properties
Properties
 
Form:
Solid  
MP:
174-176°C  
Solubility:
H2O: soluble  
Storage:
-20 ℃;Keep in dry area;  

Computed Properties
 
Complexity:
130  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  

Literature

Title: The mixture of 'ecstasy' and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations.

Journal: Archives of toxicology 20140201

Title: Effects of MDMA (ecstasy) and two of its metabolites on rat embryos in vitro.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20120801

Title: Radiosynthesis of carbon-11 labeled 6-methyldopamine ([¹¹C]MeDA).

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20120801

Title: A convenient biomimetic synthesis of optically active putative neurotoxic metabolites of MDMA ('ecstasy') from R-(-)- and S-(+)-N-methyl-α-methyldopamine precursors.

Journal: Organic & biomolecular chemistry 20120514

Title: Six months treatment with ibopamine in patients with hypotony after vitreoretinal surgery for retinal detachment, uveitis or penetrating trauma.

Journal: Retina (Philadelphia, Pa.) 20120401

Title: Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes.

Journal: British journal of pharmacology 20120201

Title: A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system.

Journal: PLoS neglected tropical diseases 20120201

Title: Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants.

Journal: Toxicology 20111118

Title: Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity.

Journal: Synapse (New York, N.Y.) 20111001

Title: Development and validation of LC-HRMS and GC-NICI-MS methods for stereoselective determination of MDMA and its phase I and II metabolites in human urine.

Journal: Journal of mass spectrometry : JMS 20110701

Title: Chiral capillary electrophoresis-mass spectrometry of tetrahydroisoquinoline-derived neurotoxins: observation of complex stereoisomerism.

Journal: Journal of chromatography. A 20110520

Title: Comparative neurochemical profile of 3,4-methylenedioxymethamphetamine and its metabolite alpha-methyldopamine on key targets of MDMA neurotoxicity.

Journal: Neurochemistry international 20110101

Title: Kinetic cooperativity of tyrosinase. A general mechanism.

Journal: Acta biochimica Polonica 20110101

Title: Pigmented deposits on a Boston keratoprosthesis from topical ibopamine.

Journal: Cornea 20100901

Title: Efficacy of 2% ibopamine on the dilation of patients with pseudoexfoliation syndrome.

Journal: European journal of ophthalmology 20100101

Title: Synthesis and in vitro cytotoxicity profile of the R-enantiomer of 3,4-dihydroxymethamphetamine (R-(-)-HHMA): comparison with related catecholamines.

Journal: Chemical research in toxicology 20100101

Title: The mydriatic effect of intracameral epinine hydrochloride.

Journal: Investigative ophthalmology & visual science 20091101

Title: Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells.

Journal: Neuroscience research 20090701

Title: Hydrolysis of 3,4-methylenedioxymethamphetamine (MDMA) metabolite conjugates in human, squirrel monkey, and rat plasma.

Journal: Analytical and bioanalytical chemistry 20090301

Title: [Metabolites of ecstasy and cytotoxicity effects].

Journal: Annales pharmaceutiques francaises 20090301

Title: Metabolites of MDMA induce oxidative stress and contractile dysfunction in adult rat left ventricular myocytes.

Journal: Cardiovascular toxicology 20090301

Title: Simultaneous liquid chromatographic-electrospray ionization mass spectrometric quantification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its metabolites 3,4-dihydroxymethamphetamine, 4-hydroxy-3-methoxymethamphetamine and 3,4-methylenedioxyamphetamine in squirrel monkey and human plasma after acidic conjugate cleavage.

Journal: Forensic science international 20090130

Title: Low pulse pressure is an independent predictor of mortality and morbidity in non ischaemic, but not in ischaemic advanced heart failure patients.

Journal: International journal of cardiology 20090124

Title: Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes.

Journal: Chemical research in toxicology 20090101

Title: [Effects of 2% ibopamine eye drops on the results of computerized visual field].

Journal: Arquivos brasileiros de oftalmologia 20090101

Title: Liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxymethamphetamine in rat brain.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081015

Title: Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') and its major metabolites in squirrel monkeys at plasma concentrations of MDMA that develop after typical psychoactive doses.

Journal: The Journal of pharmacology and experimental therapeutics 20081001

Title: [2% ibopamine vs. water-drinking test as a provocative test for glaucoma].

Journal: Arquivos brasileiros de oftalmologia 20080101

Title: Effect of methyl derivatives of dopamine on tumor necrosis factor alpha and lipid peroxidation.

Journal: Annals of the New York Academy of Sciences 20071201

Title: 3-O-methyldopamine (3-O-methoxytyramine) interferes with the internal standard 3,4-dihydroxybenzylamine in a plasma catecholamine HPLC method.

Journal: Clinical chemistry 20071101

Title: Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071001

Title: Validated liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxymethamphetamine in squirrel monkey plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070815

Title: Neurotoxicity mechanisms of thioether ecstasy metabolites.

Journal: Neuroscience 20070608

Title: [Positive ibopamine provocative test in normal-tension glaucoma suspects].

Journal: Klinische Monatsblatter fur Augenheilkunde 20070401

Title: Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity.

Journal: Pharmacogenetics and genomics 20061101

Title: A new approach for treatment of hypertension: modifying D1 dopamine receptor function.

Journal: Cardiovascular & hematological agents in medicinal chemistry 20061001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Treatment of uveitis-associated refractory ocular hypotony with topical ibopamine].

Journal: Klinische Monatsblatter fur Augenheilkunde 20060501

Title: Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma.

Journal: American journal of ophthalmology 20060301

Title: [Prostaglandin analogues reduce the ibopamine provocative test specificity in glaucoma].

Journal: Arquivos brasileiros de oftalmologia 20060101

Title: Correlation between the ibopamine provocative test and the diurnal tension curve in glaucoma patients.

Journal: Arquivos brasileiros de oftalmologia 20060101

Title: Comparison between the 1% and 2% ibopamine provocative test in primary open-angle glaucoma patients: sensitivity, specificity and tolerability.

Journal: Arquivos brasileiros de oftalmologia 20060101

Title: The comparison of topical ibopamine 2% with tonography to identify the outflow resistance in eyes with ocular hypertension.

Journal: Ophthalmic research 20050101

Title: A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice.

Journal: British journal of pharmacology 20050101

Title: Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites in human samples including the catechol-type metabolite (3,4-dihydroxymethamphetamine).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040901

Title: The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine.

Journal: Toxicology 20040805

Title: Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro.

Journal: Chemical research in toxicology 20040501

Title: Ibopamine provocative test and glaucoma: consideration of factors that may influence the examination.

Journal: Current eye research 20040301

Title: Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates.

Journal: Archives of toxicology 20040101

Title: The effects of 2% ibopamine eye drops on the intraocular pressure and pupil motility of patients with open-angle glaucoma.

Journal: European journal of ophthalmology 20040101

Title: Effect of ibopamine on aqueous humor production in normotensive humans.

Journal: Investigative ophthalmology & visual science 20031101

Title: Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy).

Journal: Brain research 20031017

Title: Apparent heterogeneous responsiveness of human platelet rich plasma to catecholamines.

Journal: Platelets 20030501

Title: Effects of ibopamine eye drops on intraocular pressure and aqueous humor flow in healthy volunteers and patients with open-angle glaucoma.

Journal: European journal of ophthalmology 20030501

Title: Comparative study of the effects of 2% ibopamine, 10% phenylephrine, and 1% tropicamide on the anterior segment.

Journal: Investigative ophthalmology & visual science 20030101

Title: High-performance liquid chromatography with electrochemical detection applied to the analysis of 3,4-dihydroxymethamphetamine in human plasma and urine.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020405

Title: Synthesis and capillary electrophoretic analysis of enantiomerically enriched reference standards of MDMA and its main metabolites.

Journal: Bioorganic & medicinal chemistry 20020401

Title: Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis.

Journal: Journal of analytical toxicology 20020401

Title: Ibopamine test and frequency doubling perimetry in early glaucoma diagnosis.

Journal: Acta ophthalmologica Scandinavica. Supplement 20020101

Title: 3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans.

Journal: Chemical research in toxicology 20010901

Title: Treatment of severe ocular hypotony in AIDS patients with cytomegalovirus retinitis and cidofovir-associated uveitis.

Journal: Ocular immunology and inflammation 20010901

Title: Treatment of severe ocular hypotony in AIDS patients with cytomegalovirus retinitis and cidofovir-associated uveitis.

Journal: Ocular immunology and inflammation 20010901

Title: The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure.

Journal: International journal of cardiology 20010801

Title: Effects of 2% ibopamine on pupil, refraction, anterior segment anatomy and intraocular pressure.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010601

Title: Confounding by contraindication in a nationwide cohort study of risk for death in patients taking ibopamine.

Journal: Annals of internal medicine 20010403

Title: Serotonergic neurotoxicity of methylenedioxyamphetamine and methylenedioxymetamphetamine.

Journal: Advances in experimental medicine and biology 20010101

Title: The neurotoxic effects of methylenedioxymethamphetamine (MDMA) and its metabolites on rat brain spheroids in culture.

Journal: Cell biology and toxicology 19990601

Title: Dose-dependent separation of dopaminergic and adrenergic effects of epinine in healthy volunteers.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19951001

Title: [Asymptomatic autoimmune hemolysis linked to alpha-methyldopa. Importance of the study of erythrocyte survival in vivo].

Journal: Revue francaise de transfusion et immuno-hematologie 19820601

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Tags:62-32-8 Molecular Formula|62-32-8 MDL|62-32-8 SMILES|62-32-8 N-Methyldopamine HCl