Home Carboxes 58-39-9
58-39-9,MFCD00056798
Catalog No.:AA00E8ZO

58-39-9 | 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethan-1-ol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%(HPLC)
in stock  
$24.00   $17.00
- +
5g
98%(HPLC)
in stock  
$34.00   $24.00
- +
25g
98%
in stock  
$72.00   $50.00
- +
100g
98%
in stock  
$229.00   $160.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E8ZO
Chemical Name:
2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethan-1-ol
CAS Number:
58-39-9
Molecular Formula:
C21H26ClN3OS
Molecular Weight:
403.9686
MDL Number:
MFCD00056798
SMILES:
OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2
Properties
Properties
 
BP:
580.4°C at 760 mmHg  
Form:
Solid  
MP:
95-98?C  
Refractive Index:
1.6100 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
463  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.2  

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Selective inhibition of hepatitis C virus infection by hydroxyzine and benztropine.

Journal: Antimicrobial agents and chemotherapy 20140601

Title: Antitubercular pharmacodynamics of phenothiazines.

Journal: The Journal of antimicrobial chemotherapy 20130401

Title: Choice of randomization to clozapine versus other second generation antipsychotics in the CATIE schizophrenia trial.

Journal: Journal of psychopharmacology (Oxford, England) 20120901

Title: Bl-1020, a new γ-aminobutyric acid-enhanced antipsychotic: results of 6-week, randomized, double-blind, controlled, efficacy and safety study.

Journal: The Journal of clinical psychiatry 20120901

Title: Impact of the CATIE trial on antipsychotic prescribing patterns at a state psychiatric facility.

Journal: Schizophrenia research 20120501

Title: Social cognition and visual perception in schizophrenia inpatients treated with first-and second-generation antipsychotic drugs.

Journal: Clinical schizophrenia & related psychoses 20120401

Title: Prevalence of neuroleptic-induced restless legs syndrome in patients taking neuroleptic drugs.

Journal: Journal of the neurological sciences 20120315

Title: Attentional and emotional functioning in schizophrenia patients treated with conventional and atypical antipsychotic drugs.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Concomitant psychotropic medication use during treatment of schizophrenia patients: longitudinal results from the CATIE study.

Journal: Clinical schizophrenia & related psychoses 20111001

Title: Alternative methods for testing treatment effects on the basis of multiple outcomes: simulation and case study.

Journal: Statistics in medicine 20110720

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Periodic catatonia.

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20110501

Title: Treatment outcomes of patients with tardive dyskinesia and chronic schizophrenia.

Journal: The Journal of clinical psychiatry 20110301

Title: Post-operative nausea and vomiting prevention with perphenazine: long overdue.

Journal: European journal of anaesthesiology 20110201

Title: Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.

Journal: Molecular psychiatry 20110101

Title: Impact of second-generation antipsychotics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia.

Journal: The Journal of clinical psychiatry 20110101

Title: Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits.

Journal: The Journal of pharmacy and pharmacology 20110101

Title: Electroconvulsive therapy for the treatment of refractory mania.

Journal: Journal of psychiatric practice 20110101

Title: Investigation of neuropsychopharmacological effects of a polyherbal formulation on the learning and memory process in rats.

Journal: Journal of young pharmacists : JYP 20110101

Title: Onset of action of atypical and typical antipsychotics in the treatment of adolescent schizophrenic psychoses.

Journal: Neuro endocrinology letters 20110101

Title: Impaired cerebellar functional connectivity in schizophrenia patients and their healthy siblings.

Journal: Frontiers in psychiatry 20110101

Title: Efficacy of perphenazine to prevent postoperative nausea and vomiting: a quantitative systematic review.

Journal: European journal of anaesthesiology 20101201

Title: Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

Journal: Assay and drug development technologies 20101201

Title: Schizophrenia: The drug deadlock.

Journal: Nature 20101111

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Perphenazine solid dispersions for orally fast-disintegrating tablets: physical stability and formulation.

Journal: Drug development and industrial pharmacy 20100501

Title: The number needed to treat for all-cause medication discontinuation in the treatment of schizophrenia: consistency across world geographies and study designs.

Journal: Pharmacopsychiatry 20100501

Title: Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: potential sources of metabolic drug interactions.

Journal: Toxicology 20100411

Title: Do antipsychotic medications reduce or increase mortality in schizophrenia? A critical appraisal of the FIN-11 study.

Journal: Schizophrenia research 20100301

Title: A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20100223

Title: Effect of perphenazine enanthate on open-field test behaviour and stress-induced hyperthermia in domestic sheep.

Journal: Pharmacology, biochemistry, and behavior 20100101

Title: BL-1020, an oral antipsychotic agent that reduces dopamine activity and enhances GABAA activity, for the treatment of schizophrenia.

Journal: Current opinion in investigational drugs (London, England : 2000) 20100101

Title: An open-label tolerability study of BL-1020 antipsychotic: a novel gamma aminobutyric acid ester of perphenazine.

Journal: Clinical neuropharmacology 20100101

Title: Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats.

Journal: Pharmacology, biochemistry, and behavior 20091201

Title: BL-1020, a novel antipsychotic candidate with GABA-enhancing effects: D2 receptor occupancy study in humans.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20091201

Title: The effects of antipsychotic medications on emotion perception in patients with chronic schizophrenia in the CATIE trial.

Journal: Schizophrenia research 20091101

Title: Clinical trials design lessons from the CATIE study.

Journal: The American journal of psychiatry 20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Journal: Bioorganic & medicinal chemistry letters 20090901

Title: 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study).

Journal: Lancet (London, England) 20090822

Title: Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090801

Title: Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: a randomized, controlled 1-year follow-up comparison.

Journal: The Journal of clinical psychiatry 20090421

Title: Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.

Journal: Bioorganic & medicinal chemistry 20090315

Title: Stability of medication in early psychosis: a comparison between second-generation and low-dose first-generation antipsychotics.

Journal: Early intervention in psychiatry 20090201

Title: BL-1020: a novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophrenia.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090101

Title: Results of phase 3 of the CATIE schizophrenia trial.

Journal: Schizophrenia research 20090101

Title: Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition.

Journal: Archives of toxicology 20081201

Title: Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms.

Journal: Bipolar disorders 20081201

Title: Hiccups and dopamine.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081115

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Impact of antipsychotic treatment on nonfasting triglycerides in the CATIE Schizophrenia Trial phase 1.

Journal: Schizophrenia research 20080801

Title: Clinical experiences and clinical trials.

Journal: CNS spectrums 20080601

Title: A mutual prodrug ester of GABA and perphenazine exhibits antischizophrenic efficacy with diminished extrapyramidal effects.

Journal: Journal of medicinal chemistry 20080508

Title: Acute dystonia induced by the combination of midodrine and perphenazine.

Journal: Journal of neurology 20080501

Title: Did CATIE influence antipsychotic use?

Journal: Psychiatric services (Washington, D.C.) 20080501

Title: Introduction to the CATIE special section.

Journal: Psychiatric services (Washington, D.C.) 20080501

Title: What CATIE found: results from the schizophrenia trial.

Journal: Psychiatric services (Washington, D.C.) 20080501

Title: Employment outcomes in a randomized trial of second-generation antipsychotics and perphenazine in the treatment of individuals with schizophrenia.

Journal: The journal of behavioral health services & research 20080401

Title: The effectiveness of antipsychotic medications in patients who use or avoid illicit substances: results from the CATIE study.

Journal: Schizophrenia research 20080301

Title: Metoclopramide, an increasingly recognized cause of tardive dyskinesia.

Journal: Journal of clinical pharmacology 20080301

Title: A somatic type delusional disorder secondary to peripheral neuropathy: a case report.

Journal: Psychiatria Danubina 20080301

Title: Treatment of idiopathic recurrent priapism with fluoxetine and low dose Perphenazine.

Journal: JPMA. The Journal of the Pakistan Medical Association 20080301

Title: Discontinuation of lithium augmentation in geriatric patients with unipolar depression: a systematic review.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20080201

Title: Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia.

Journal: Biological psychiatry 20080101

Title: Clinical characteristics and psychopathological profile of patients with vulvodynia: an observational and descriptive study.

Journal: Dermatology (Basel, Switzerland) 20080101

Title: [Consumption of inappropriate psychotropic drugs in residential homes for the elderly: comparative study between 2001 and 2006].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20080101

Title: Clinical implications of the CATIE schizophrenia trials: day-to-day management lessons for Australasian psychiatrists.

Journal: Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists 20071201

Title: Aripiprazole and perphenazine: no difference.

Journal: The Journal of clinical psychiatry 20071101

Title: CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine.

Journal: Pharmacogenetics and genomics 20071101

Title: Neuroleptic malignant syndrome resulting from a complex drug-drug interaction: 'I don't see 'em!'.

Journal: Journal of psychiatric practice 20070901

Title: Weight gain in newly diagnosed first-episode psychosis patients and healthy comparisons: one-year analysis.

Journal: Schizophrenia research 20070701

Title: HPLC quantification of perphenazine in sheep plasma: application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

Title: Long-acting neuroleptics used in wildlife management do not impair thermoregulation or physical activity in goats (Capra hircus).

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070601

Title: Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial.

Journal: Archives of general psychiatry 20070601

Title: CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited.

Journal: Pharmacogenetics and genomics 20070501

Title: Permanent lithium-induced cerebellar toxicity: three cases and review of literature.

Journal: Movement disorders : official journal of the Movement Disorder Society 20070315

Title: Serotonin and dopamine receptor gene polymorphisms and the risk of extrapyramidal side effects in perphenazine-treated schizophrenic patients.

Journal: Psychopharmacology 20070301

Title: Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study.

Journal: The American journal of psychiatry 20070301

Title: Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study.

Journal: The American journal of psychiatry 20070301

Title: Aripiprazole for treatment-resistant schizophrenia: results of a multicenter, randomized, double-blind, comparison study versus perphenazine.

Journal: The Journal of clinical psychiatry 20070201

Title: [Antipsychotics--clever choices].

Journal: Lakartidningen 20070201

Title: Relative risk of glucose elevation during antipsychotic exposure in a Veterans Administration population.

Journal: International clinical psychopharmacology 20070101

Title: Nerve growth factor mRNA expression in the regenerating antler tip of red deer (Cervus elaphus).

Journal: PloS one 20070101

Title: Routine multimodal antiemesis including low-dose perphenazine in an ambulatory surgery unit of a university hospital: a 10-year history. Supplement to: Eliminating postoperative nausea and vomiting in outpatient surgery with multimodal strategies including low doses of nonsedating, off-patent antiemetics: is 'zero tolerance' achievable?

Journal: TheScientificWorldJournal 20070101

Title: [Neuroleptic treatment and neurological soft signs in schizophrenic patients].

Journal: Therapie 20070101

Title: Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophrenia.

Journal: The American journal of psychiatry 20061201

Title: Differential early onset of therapeutic response with risperidone vs conventional antipsychotics in patients with chronic schizophrenia.

Journal: International clinical psychopharmacology 20060901

Title: [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].

Journal: No to shinkei = Brain and nerve 20060601

Title: Selecting antipsychotics in schizophrenia: lessons from CATIE.

Journal: Journal of psychopharmacology (Oxford, England) 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Antipsychotic drugs and schizophrenia.

Journal: The New England journal of medicine 20060119

Title: Antipsychotic drugs and schizophrenia.

Journal: The New England journal of medicine 20060119

Title: Interpreting the results of the CATIE study.

Journal: Psychiatric services (Washington, D.C.) 20060101

Title: Interpreting the results of the CATIE study.

Journal: Psychiatric services (Washington, D.C.) 20060101

Title: Interpreting the results of the CATIE study.

Journal: Psychiatric services (Washington, D.C.) 20060101

Title: In vitro phototoxicity of phenothiazines: involvement of stable UVA photolysis products formed in aqueous medium.

Journal: Chemical research in toxicology 20060101

Title: Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia.

Journal: BMC psychiatry 20060101

Title: The CATIE schizophrenia effectiveness trial.

Journal: Schizophrenia research 20051201

Title: Stability and characterization of perphenazine aerosols generated using the capillary aerosol generator.

Journal: International journal of pharmaceutics 20051013

Title: Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.

Journal: The New England journal of medicine 20050922

Title: PASS assisted search and evaluation of some azetidin-2-ones as C.N.S. active agents.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20050803

Title: Depot perphenazine decanoate and enanthate for schizophrenia.

Journal: The Cochrane database of systematic reviews 20050720

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: [Differentiation-inducing effects of perphenazine on K562 leukemia cells].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20050601

Title: Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs.

Journal: Psychopharmacology 20050501

Title: Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine.

Journal: The international journal of biochemistry & cell biology 20050401

Title: Effect of anionic additive type on ion pair formation constants of basic pharmaceuticals.

Journal: Journal of chromatography. A 20050401

Title: Kinetic spectrophotometric method for determination of perphenazine based on monitoring the oxidation intermediate by applying a stopped-flow technique.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050301

Title: Application of two chemometric methods for the determination of imipramine, amitriptyline and perphenazine in content uniformity and drug dissolution studies.

Journal: Journal of pharmaceutical and biomedical analysis 20050223

Title: Perphenazine for schizophrenia.

Journal: The Cochrane database of systematic reviews 20050125

Title: Antiemetics in outpatient regional anesthesia for invasive orthopedic surgery.

Journal: International anesthesiology clinics 20050101

Title: Switching patients from olanzapine or risperidone to a combination treatment using perphenazine plus buspirone: evaluation of antipsychotic efficacy and side-effects, including extrapyramidal effects and weight loss.

Journal: Nordic journal of psychiatry 20050101

Title: Preliminary studies on phenothiazine-mediated reversal of multidrug resistance in mouse lymphoma and COLO 320 cells.

Journal: In vivo (Athens, Greece) 20050101

Title: Comparison of the effect of the R2 phenothiazine ring substituent on fluphenazine and perphenazine interactions with cyclodextrins.

Journal: Acta poloniae pharmaceutica 20050101

Title: A cross-validation study on the relationship between central D2 receptor occupancy and serum perphenazine concentration.

Journal: Psychopharmacology 20040901

Title: Nausea and vomiting after outpatient ACL reconstruction with regional anesthesia: are lumbar plexus blocks a risk factor?

Journal: Journal of clinical anesthesia 20040601

Title: Photo-distributed neutrophilic drug eruption and adult respiratory distress syndrome associated with antidepressant therapy.

Journal: Journal of cutaneous pathology 20040201

Title: An unexpected increase of troponin I after perphenazine depot injection.

Journal: The Annals of pharmacotherapy 20040201

Title: Double-blind comparison of the continued use of antipsychotic treatment versus its discontinuation in remitted manic patients.

Journal: The American journal of psychiatry 20040101

Title: Survey on schizophrenia treatment in Mexico: perception and antipsychotic prescription patterns.

Journal: BMC psychiatry 20040101

Title: Induction of the rabbit syndrome following coadministration of paroxetine, perphenazine, and amitriptyline.

Journal: Clinical neuropharmacology 20040101

Title: Schizophrenia, VI: Treatments.

Journal: The American journal of psychiatry 20031001

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry 20030703

Title: Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition.

Journal: Pharmacology 20030601

Title: Photosensitization of DNA strand breaks by three phenothiazine derivatives.

Journal: Chemical research in toxicology 20030501

Title: How long should patients with psychotic depression stay on the antipsychotic medication?

Journal: The Journal of clinical psychiatry 20030401

Title: H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030301

Title: Phenothiazine radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase: enzyme protection by radical scavengers.

Journal: Free radical research 20030301

Title: New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization.

Journal: Journal of medicinal chemistry 20030102

Title: Drug-induced toxic myocarditis.

Journal: Texas Heart Institute journal 20030101

Title: [Safety and efficacy of olanzapine versus perphenazine in patients with schizophrenia: results of multicenter, 18-week, double-blind clinical trial].

Journal: Psychiatria polska 20030101

Title: Disturbed glucose metabolism among patients taking olanzapine and typical antipsychotics.

Journal: Psychopharmacology bulletin 20030101

Title: Simultaneous dissolution profiles of two drugs, sulfadiazine-trimethoprim and amitriptyline-perphenazine, in solid oral dosage forms by a FIA manifold provided with a single spectrophotometric detector.

Journal: Journal of pharmaceutical and biomedical analysis 20021015

Title: Hydrophobia as a rare presentation of Cotard's syndrome: a case report.

Journal: Acta psychiatrica Scandinavica 20020801

Title: Role of adenosine in drug-induced catatonia in mice.

Journal: Indian journal of experimental biology 20020801

Title: [Simple preparation and evaluations of amide-octyl-bonded phase].

Journal: Se pu = Chinese journal of chromatography 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Quantification of perphenazine in eurasian otter (Lutra lutra lutra) urine samples by gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020325

Title: Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients.

Journal: The American journal of psychiatry 20020301

Title: Extractive-spectrophotometric determination of some phenothiazines with dipicrylamine and picric acid.

Journal: Journal of pharmaceutical and biomedical analysis 20020101

Title: Simultaneous determination of promethazine, chlorpromazine, and perphenazine by multivariate calibration methods and derivative spectrophotometry.

Journal: Journal of AOAC International 20020101

Title: Open trial study of a combined antidepressant (amitryptiline, perphenazine, diazepam) versus fluoxetine or imipramine in ambulatory depressed patients.

Journal: Proceedings of the Western Pharmacology Society 20020101

Title: Evaluation of the neurotoxic activity of typical and atypical neuroleptics: relevance to iatrogenic extrapyramidal symptoms.

Journal: Cellular and molecular neurobiology 20011201

Title: Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland.

Journal: Molecular endocrinology (Baltimore, Md.) 20011101

Title: Fluvoxamine and perphenazine for psychosis in Alzheimer's disease: pharmacokinetic considerations.

Journal: The Journal of nervous and mental disease 20011101

Title: Agranulocytosis and neutropenia with typical and atypical neuroleptics.

Journal: The American journal of psychiatry 20011001

Title: Effects of ADP on different inhibitory properties of brain glutamate dehydrogenase isoproteins by perphenazine.

Journal: Biochimie 20010901

Title: Evaluation of long-term sedation in cheetah (Acinonyx jubatus) with perphenazine enanthate and zuclopenthixol acetate.

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010901

Title: Antipsychotic radioreceptor assay: a modification identifying selective receptor effects.

Journal: Therapeutic drug monitoring 20010801

Title: Antipsychotic-induced extrapyramidal syndromes. Risperidone compared with low- and high-potency conventional antipsychotic drugs.

Journal: European journal of clinical pharmacology 20010701

Title: Noninvasive monitoring of adrenocortical activity in roe deer (Capreolus capreolus) by measurement of fecal cortisol metabolites.

Journal: General and comparative endocrinology 20010701

Title: Relevance of liver enzyme elevations with four different neuroleptics: a retrospective review of 7,263 treatment courses.

Journal: Journal of clinical psychopharmacology 20010401

Title: Therapeutic drug monitoring of haloperidol, perphenazine, and zuclopenthixol in serum by a fully automated sequential solid phase extraction followed by high-performance liquid chromatography.

Journal: Therapeutic drug monitoring 20010401

Title: Fluvoxamine for psychosis in Alzheimer's disease.

Journal: The Journal of nervous and mental disease 20010201

Title: The changes of biological markers and treatment efficacy in schizophrenia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20010201

Title: Exacerbation of psychosis by phenylpropanolamine.

Journal: The American journal of psychiatry 20000601

Title: [Diabetes mellitus after treatment with clozapine].

Journal: Nederlands tijdschrift voor geneeskunde 20000226

Title: Perphenazine-induced hiccups.

Journal: Pharmacopsychiatry 19990301

Title: Acquired aplastic anemia secondary to perphenazine.

Journal: The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 19990101

Title: Olanzapine use in women with antipsychotic-induced hyperprolactinemia.

Journal: The American journal of psychiatry 19981001

Title: Association of plasma homovanillic acid with behavioral symptoms in patients diagnosed with dementia: a preliminary report.

Journal: Biological psychiatry 19971201

Title: Induction of mania by risperidone resistant to mood stabilizers.

Journal: Journal of clinical psychopharmacology 19970201

Title: Relapse following clozapine withdrawal: effect of neuroleptic drugs and cyproheptadine.

Journal: Psychopharmacology 19960301

Title: BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 19960101

Title: The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery.

Journal: Anesthesia and analgesia 19950701

Title: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19940301

Title: Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations.

Journal: Acta psychiatrica Scandinavica 19931201

Title: D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptor participation in experimental catalepsy in rats.

Journal: Psychopharmacology 19920101

Title: Extrapyramidal symptoms and their relationship to clinical efficacy under perphenazine treatment. A controlled prospective handwriting-test study in 22 acutely ill schizophrenic patients.

Journal: Pharmacopsychiatry 19910701

Title: The relationship between blood perphenazine levels, early resolution of psychotic symptoms, and side effects.

Journal: The Journal of clinical psychiatry 19900801

Title: Neurologic approach to drug-induced movement disorders: a study of 125 patients.

Journal: Southern medical journal 19900501

Title: Zuclopenthixol and perphenazine in patients with acute psychotic states. A double-blind multicentre study.

Journal: Pharmacopsychiatry 19870701

Title: Neuroleptic malignant syndrome during perphenazine treatment.

Journal: Pharmacology & toxicology 19870301

Title: L-tryptophan in drug-induced movement disorders with insomnia.

Journal: The New England journal of medicine 19860508

Title: Tourette-like syndrome following low dose short-term neuroleptic treatment.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 19860501

Title: A case of progressive hemichorea responsive to high-dose reserpine.

Journal: The Journal of clinical psychiatry 19860301

Title: Effect of different neuroleptics in tardive dyskinesia and parkinsonism. A video-controlled multicenter study with chlorprothixene, perphenazine, haloperidol and haloperidol + biperiden. Nordic Dyskinesia Study Group.

Journal: Psychopharmacology 19860101

Title: GABAergic, dopaminergic and cholinergic interactions in perphenazine-induced catatonia in rats.

Journal: Archives internationales de pharmacodynamie et de therapie 19851201

Title: Pharmacology in vivo of the phenylindan derivative, Lu 19-005, a new potent inhibitor of dopamine, noradrenaline and 5-hydroxytryptamine uptake in rat brain.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19850401

Title: Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19840901

Title: Unique sensitivity of Hb Zürich to oxidative injury by phenazopyridine: reversal of the effects by elevating carboxyhemoglobin levels in vivo and in vitro.

Journal: American journal of hematology 19830601

Title: Cerebellar syndrome following neuroleptic induced heat stroke.

Journal: Journal of neurology, neurosurgery, and psychiatry 19830201

Title: Capgras phenomenon, delirium, and transient hepatic dysfunction.

Journal: Hospital & community psychiatry 19820501

Title: Dose-response relationships of perphenazine in the treatment of acute psychoses.

Journal: Psychopharmacology 19820101

Title: Prolactin and the small intestine. Effect of hyperprolactinaemia on mucosal structure in the rat.

Journal: Gut 19810701

Title: Actions of clonidine on convulsions and behaviour.

Journal: Archives internationales de pharmacodynamie et de therapie 19810701

Title: Tricyclic antidepressants and alcoholic blackouts.

Journal: The Journal of nervous and mental disease 19810601

Title: Plasma levels of perphenazine (Trilafon) related to development of extrapyramidal side effects.

Journal: Psychopharmacology 19810101

Title: Pituitary sensitivity to LHRH in hyperprolactinemia induced by perphenazine and renal pituitary transplants in female rats.

Journal: Biology of reproduction 19800401

Title: Somnambulistic-like episodes secondary to combined lithium-neuroleptic treatment.

Journal: The British journal of psychiatry : the journal of mental science 19791101

Title: Electrophysiologic studies of perphenazine and protriptyline in a patient with psychotropic drug-induced ventricular fibrillation.

Journal: The American journal of medicine 19790801

Title: Seven cases of somnambulism induced by drugs.

Journal: The American journal of psychiatry 19790701

Title: Metoclopramide and dystonic reactions in Sardinians.

Journal: Lancet (London, England) 19790623

Title: Toxic psychosis with cimetidine.

Journal: The American journal of psychiatry 19790501

Title: Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule.

Journal: Canadian Medical Association journal 19781007

Title: [Acute dystonia in children. 2 cases caused by perphenazine (Trilafon)].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 19780310

Title: Effects and side-effects of bromperidol in comparison with other antipsychotic drugs.

Journal: Acta psychiatrica Belgica 19780101

Title: Drug-induced anaphylaxis, convulsions, deafness, and extrapyramidal symptoms.

Journal: Lancet (London, England) 19770312

Title: Asymptomatic idiopathic syndrome of prolonged Q-T interval in a 45-year-old woman. Ventricular tachyarrhythmias precipitated by hypokalemia and therapy with amitriptyline and prephenazine.

Journal: Chest 19770201

Title: Tetany, tetanus or drug reaction? A case report.

Journal: British journal of anaesthesia 19760701

Title: High-dosage and versatile drug therapy with treatment-resistant psychotic patients.

Journal: Hospital & community psychiatry 19760101

Title: [Psychometric effects of perphenacine below the 'neuroleptic threshold' (author's transl)].

Journal: Pharmakopsychiatrie, Neuro-Psychopharmakologie 19751201

Title: Letter: Side-effects of perphenazine.

Journal: Lancet (London, England) 19750621

Title: Drug-induced dystonia.

Journal: The American journal of psychiatry 19750501

Title: Tardive dyskinesia treated with pimozide.

Journal: Journal of the neurological sciences 19750401

Title: Tissue metabolites of trifluorperazine, fluphenazine, prochlorperazine, and perphenazine. Kinetics in chronic treatment.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19750101

Title: Reversal of delirium induced by tricyclic antidepressant drugs with physostigmine.

Journal: The American journal of psychiatry 19741101

Title: Piritramide and pethidine. A comparison of their use as supplements in general anaesthesia.

Journal: Anaesthesia 19741101

Title: The mechanism of the potentiating effect of antidepressant drugs on the protective influenc oe of diphenhydramine in experimental catatonia. The role of histamine.

Journal: Pharmacology 19740101

Title: Idiosyncratic responses to phenothiazines.

Journal: British medical journal 19720122

Title: A review of clinical studies with combinations of fluphenazine and nortriptyline.

Journal: Current medical research and opinion 19720101

Title: Increased sensitivity to neuroleptics in rats with lesions of the central nervous system.

Journal: Psychopharmacologia 19720101

Title: Sudden death in phenothiazine therapy. (A clinicopathologic study of 12 cases).

Journal: The Psychiatric quarterly 19700101

Title: Iatrogenic epilepsy due to antidepressant drugs.

Journal: British medical journal 19691011

Title: Dystonic reaction to perphenazine.

Journal: Lancet (London, England) 19690809

Title: Perphenazine dystonia presenting as recurrent dislocation of the jaw.

Journal: The Journal of laryngology and otology 19690101

Title: Phenothiazines and diabetes in hospitalized women.

Journal: The American journal of psychiatry 19680101

Title: Oculogyric crises due to phenothiazines.

Journal: British medical journal 19670722

Title: Side-effects of phenothiazines.

Journal: British medical journal 19670401

Title: Phenothiazines in early labour.

Journal: British medical journal 19670211

Title: The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy.

Journal: The Psychiatric quarterly 19670101

Title: Specific therapeutic actions of acetophenazine, perphenazine, and benzquinamide in newly admitted schizophrenic patients.

Journal: Clinical pharmacology and therapeutics 19670101

Title: Drug-induced extrapyramidal symptoms: their incidence and treatment.

Journal: The American journal of psychiatry 19670101

Title: A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism.

Journal: The British journal of psychiatry : the journal of mental science 19660601

Title: The effect of SA 97, perphenazine, and hydroxyzine on epinephrine-induced cardiac arrhythmias during methoxyflurane anaesthesia in dogs.

Journal: Canadian Anaesthetists' Society journal 19620101

Title: The effect of perphenazine on epinephrine-induced cardiac arrhythmias in dogs. II. Anaesthesia with cyclopropane, chloroform, and trichlorethylene.

Journal: Canadian Anaesthetists' Society journal 19590701

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:58-39-9 Molecular Formula|58-39-9 MDL|58-39-9 SMILES|58-39-9 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethan-1-ol |Heterocyclic_Building_Blocks