Title: 1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism.
Journal: Toxicology letters20170415
Title: Sterigmatocystin-induced checkpoint adaptation depends on Chk1 in immortalized human gastric epithelial cells in vitro.
Journal: Archives of toxicology20170101
Title: The ovarian DNA damage repair response is induced prior to phosphoramide mustard-induced follicle depletion, and ataxia telangiectasia mutated inhibition prevents PM-induced follicle depletion.
Journal: Toxicology and applied pharmacology20160201
Title: Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis.
Journal: Chemical research in toxicology20160119
Title: Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics.
Journal: Environmental health perspectives20160101
Title: γ-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
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Title: Repairing of N-mustard derivative BO-1055 induced DNA damage requires NER, HR, and MGMT-dependent DNA repair mechanisms.
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Title: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
Journal: Molecular and cellular biology20150401
Title: Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity.
Journal: Nucleic acids research20141110
Title: Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response.
Journal: The Journal of pharmacology and experimental therapeutics20140701
Title: Direct activation of ATM by resveratrol under oxidizing conditions.
Journal: PloS one20140101
Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal20130415
Title: Osteoblasts survive the arsenic trioxide treatment by activation of ATM-mediated pathway.
Journal: Biochemical pharmacology20130401
Title: The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?
Journal: The Journal of pharmacology and experimental therapeutics20121201
Title: Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells.
Journal: Oral oncology20121101
Title: Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells.
Journal: DNA repair20121101
Title: Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.
Journal: Toxicology20120904
Title: Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.
Journal: Bioorganic & medicinal chemistry letters20120901
Title: Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells.
Journal: Chinese journal of cancer20120801
Title: DNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATM.
Journal: Chemical research in toxicology20120716
Title: Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.
Journal: The Journal of biological chemistry20120504
Title: ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability.
Journal: Cell cycle (Georgetown, Tex.)20120501
Title: Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death.
Journal: Biochemical and biophysical research communications20120330
Title: Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.
Journal: Chembiochem : a European journal of chemical biology20120319
Title: Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.
Journal: Biochemical pharmacology20120315
Title: DNA damage responses in cells exposed to sulphur mustard.
Journal: Toxicology letters20120225
Title: The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals.
Journal: Toxicological sciences : an official journal of the Society of Toxicology20120101
Title: DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines.
Journal: PloS one20120101
Title: Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20120101
Title: Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A.
Journal: PloS one20120101
Title: Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.
Journal: The Journal of biological chemistry20111111
Title: AT cells are not radiosensitive for simple chromosomal exchanges at low dose.
Journal: Mutation research20111101
Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Journal: Nature biotechnology20111101
Title: Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.
Journal: Oncogene20111013
Title: DNA damage-sensing kinases mediate the mouse 2-cell embryo's response to genotoxic stress.
Journal: Biology of reproduction20110901
Title: DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.
Journal: Molecular pharmacology20110801
Title: 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.
Journal: Toxicology and applied pharmacology20110801
Title: Asperlin induces G₂/M arrest through ROS generation and ATM pathway in human cervical carcinoma cells.
Journal: Biochemical and biophysical research communications20110610
Title: KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.
Journal: Nature structural & molecular biology20110605
Title: Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells.
Journal: Apoptosis : an international journal on programmed cell death20110501
Title: Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.
Journal: Journal of medicinal chemistry20110414
Title: Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.
Journal: Nature chemical biology20110413
Title: Impact of G₂ checkpoint defect on centromeric instability.
Journal: Oncogene20110317
Title: Three independent mechanisms for arrest in G2 after ionizing radiation.
Journal: Cell cycle (Georgetown, Tex.)20110301
Title: [The role of DNA double strains damage repairing mechanisms in high glucose-induced endothelial senescence].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition20110301
Title: Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-κB activation.
Journal: DNA repair20110207
Title: ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.
Journal: The EMBO journal20110202
Title: Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
Journal: Nature genetics20110201
Title: Targeting the DNA double strand break repair machinery in prostate cancer.
Journal: PloS one20110101
Title: Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.
Journal: PloS one20110101
Title: ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.
Journal: Science signaling20101207
Title: Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease.
Journal: Cellular and molecular life sciences : CMLS20101101
Title: Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.
Journal: The Journal of biological chemistry20101022
Title: ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
Journal: Molecular cell20101008
Title: Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
Journal: International journal of radiation oncology, biology, physics20100901
Title: DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin.
Journal: Toxicological sciences : an official journal of the Society of Toxicology20100501
Title: ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation.
Journal: Journal of cellular biochemistry20100501
Title: The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
Journal: Molecular cancer therapeutics20100101
Title: Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent.
Journal: International journal of radiation oncology, biology, physics20091201
Title: Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.
Journal: Molecular cancer therapeutics20091001
Title: ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions.
Journal: International journal of radiation oncology, biology, physics20090901
Title: Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.
Journal: Carcinogenesis20090801
Title: Coactivation of ATM/ERK/NF-kappaB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes.
Journal: Free radical biology & medicine20090601
Title: Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells.
Journal: Cancer research20090415
Title: ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype.
Journal: Blood20090409
Title: Cadmium-induced adaptive response in cells of Chinese hamster ovary cell lines with varying DNA repair capacity.
Journal: Radiation research20090401
Title: DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide.
Journal: Toxicology20090329
Title: DNA double helix unwinding triggers transcription block-dependent apoptosis: a semiquantitative probe of the response of ATM, RNAPII, and p53 to two DNA intercalators.
Journal: Chemical research in toxicology20090316
Title: The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.
Journal: Radiation oncology (London, England)20090101
Title: p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.
Journal: Oncogene20080605
Title: Chk1 and Claspin potentiate PCNA ubiquitination.
Journal: Genes & development20080501
Title: Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20080315
Title: Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling.
Journal: DNA repair20080301
Title: A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.
Journal: Nature chemical biology20080201
Title: Rapid activation of ATM on DNA flanking double-strand breaks.
Journal: Nature cell biology20071101
Title: Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Journal: Journal of medicinal chemistry20070419
Title: Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.
Journal: Cancer research20070201
Title: Small molecule-based reversible reprogramming of cellular lifespan.
Journal: Nature chemical biology20060701
Title: Emerging cancer therapeutic opportunities target DNA-repair systems.
Journal: Trends in pharmacological sciences20060601
Title: Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.
Journal: Nucleic acids research20060101
Title: Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.
Journal: Biochemical pharmacology20051219
Title: hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.
Journal: Cell20051216
Title: Features of selective kinase inhibitors.
Journal: Chemistry & biology20050601
Title: Chronicles in drug discovery.
Journal: Drug news & perspectives20050601
Title: Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.
Journal: Nature cell biology20050501
Title: ATM: HIV-1's Achilles heel?
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Title: Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.
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