Catalog No.:AA00E9Q6

56617-43-7 | 1-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

Name: Name:1-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid
Brand: AABLOCKS
SKU: AA00E9Q6
Availability: InStock
Rating: 90 (10 reviews)

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97%

in stock

$112.00 $78.00

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97%

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25g

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$976.00 $683.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA00E9Q6

Chemical Name:

1-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

CAS Number:

56617-43-7

Molecular Formula:

C11H10FNO3

Molecular Weight:

223.2004

MDL Number:

MFCD01569311

SMILES:

OC(=O)C1CN(C(=O)C1)c1ccc(cc1)F

Properties

BP:

514.4°C at 760 mmHg

Storage:

Keep in dry area;2-8℃;

Computed Properties

Complexity:

300

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

Undefined Atom Stereocenter Count:

XLogP3:

0.6

Downstream Synthesis Route

67-56-1

56617-43-7

133747-62-3

[1]Watanabe,S.;Ogawa,K.;Ohno,T.;Yano,S.;Yamada,H.;Shirasaka,T.[EuropeanJournalofMedicinalChemistry,1994,vol.29,#9,p.675-686]

[2]Vaickelioniene;Mickevicius[ChemistryofHeterocyclicCompounds,2006,vol.42,#6,p.753-760]

[3]CurrentPatentAssignee:AMGENINC-WO2009/51718,2009,A2Locationinpatent:Page/Pagecolumn38

97-65-4

371-40-4

56617-43-7

[1]Chang,Kang;Shi,Yanxia;Chen,Jianqin;He,Zenghui;Xu,Zheng;Zhao,Zhenjiang;Zhu,Weiping;Li,Honglin;Xu,Yufang;Li,Baoju;Qian,Xuhong[MedChemComm,2016,vol.7,#9,p.1849-1857]

[2]CurrentPatentAssignee:CHINESEACADEMYOFMEDICALSCIENCES-CN103450163,2017,BLocationinpatent:Paragraph0052;0053;0054

[3]Watanabe,S.;Ogawa,K.;Ohno,T.;Yano,S.;Yamada,H.;Shirasaka,T.[EuropeanJournalofMedicinalChemistry,1994,vol.29,#9,p.675-686]

[4]Vaickelioniene;Mickevicius[ChemistryofHeterocyclicCompounds,2006,vol.42,#6,p.753-760]

[5]CurrentPatentAssignee:GILEADSCIENCESINC-WO2005/61470,2005,A1Locationinpatent:Page/Pagecolumn58

[6]CurrentPatentAssignee:AMGENINC-WO2009/51718,2009,A2Locationinpatent:Page/Pagecolumn38

[7]CurrentPatentAssignee:ROCHEHOLDINGAG-US2012/190700,2012,A1Locationinpatent:Page/Pagecolumn34

[8]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2012/98132,2012,A1Locationinpatent:Page/Pagecolumn68

[9]Locationinpatent:schemeortablePackiarajan,Mathivanan;MazzaFerreira,ChristineG.;Hong,Sang-Phyo;White,AndrewD.;Chandrasena,Gamini;Pu,Xiaosui;Brodbeck,RobbinM.;Robichaud,AlbertJ.[BioorganicandMedicinalChemistryLetters,2012,vol.22,#17,p.5658-5662]

[10]Basu,Sujay;Barawkar,DineshA.;Ramdas,Vidya;Waman,Yogesh;Patel,Meena;Panmand,Anil;Kumar,Santosh;Thorat,Sachin;Bonagiri,Rajesh;Jadhav,Dilip;Mukhopadhyay,Partha;Prasad,Vandna;Reddy,B.Srinivasa;Goswami,Arnab;Chaturvedi,Sandhya;Menon,Suraj;Quraishi,Azfar;Ghosh,Indraneel;Dusange,Sushant;Paliwal,Shalini;Kulkarni,Abhay;Karande,Vikas;Thakre,Rhishikesh;Bedse,Gaurav;Rouduri,Sreekanth;Gundu,Jayasagar;Palle,VenkataP.;Chugh,Anita;Mookhtiar,KasimA.[EuropeanJournalofMedicinalChemistry,2017,vol.127,p.986-996]

[11]Takasaki,Ichiro;Ogashi,Haruna;Okada,Takuya;Shimodaira,Ayaka;Hayakawa,Daichi;Watanabe,Ai;Miyata,Atsuro;Kurihara,Takashi;Gouda,Hiroaki;Toyooka,Naoki[EuropeanJournalofMedicinalChemistry,2020,vol.186]

56617-43-7

669696-68-8

[1]Vaickelioniene;Mickevicius[ChemistryofHeterocyclicCompounds,2006,vol.42,#6,p.753-760]

56617-43-7

133747-62-3

[1]Chang,Kang;Shi,Yanxia;Chen,Jianqin;He,Zenghui;Xu,Zheng;Zhao,Zhenjiang;Zhu,Weiping;Li,Honglin;Xu,Yufang;Li,Baoju;Qian,Xuhong[MedChemComm,2016,vol.7,#9,p.1849-1857]

51-45-6

56617-43-7

N-2-(1H-imidazol-4-yl)ethyl-1-(4-fluorophenyl)-5-oxo-3-pyrrolidinecarboxamide

[1]Takasaki,Ichiro;Ogashi,Haruna;Okada,Takuya;Shimodaira,Ayaka;Hayakawa,Daichi;Watanabe,Ai;Miyata,Atsuro;Kurihara,Takashi;Gouda,Hiroaki;Toyooka,Naoki[EuropeanJournalofMedicinalChemistry,2020,vol.186]

Literature

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

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