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6145-41-1,MFCD08236718
Catalog No.:AA00E9XI

6145-41-1 | 1-(3-Chlorophenyl)guanidine

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Purity
Availability
Price(USD)
Quantity
  
100mg
95%
in stock  
$214.00   $150.00
- +
250mg
95%
in stock  
$284.00   $199.00
- +
1g
95%
in stock  
$681.00   $477.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00E9XI
Chemical Name:
1-(3-Chlorophenyl)guanidine
CAS Number:
6145-41-1
Molecular Formula:
C7H8ClN3
Molecular Weight:
169.6115
MDL Number:
MFCD08236718
SMILES:
NC(=N)Nc1cccc(c1)Cl
Properties
Properties
 
BP:
342.1°C at 760 mmHg  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
154  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
1  

Downstream Synthesis Route

[1]Patent:WO2012/85167,2012,A1.Locationinpatent:Page/Pagecolumn60

[2]Patent:WO2012/85167,2012,A1.Locationinpatent:Page/Pagecolumn51

Literature

Title: Antinociceptive synergism of MD-354 and clonidine. Part II. The alpha-adrenoceptor component.

Journal: Basic & clinical pharmacology & toxicology 20100801

Title: MD-354 selectively antagonizes the antinociceptive effects of (-)nicotine in the mouse tail-flick assay.

Journal: Psychopharmacology 20100701

Title: A comprehensive study on the 5-hydroxytryptamine(3A) receptor binding of agonists serotonin and m-chlorophenylbiguanidine.

Journal: Bioorganic & medicinal chemistry 20090815

Title: MD-354: what is it good for?

Journal: CNS drug reviews 20070101

Title: The 5-HT3 receptor partial agonist MD-354 (meta-chlorophenylguanidine) enhances the discriminative stimulus actions of (+)amphetamine in rats.

Journal: Pharmacology, biochemistry, and behavior 20070101

Title: Antinociception: mechanistic studies on the action of MD-354 and clonidine. Part 1. The 5-HT3 component.

Journal: European journal of pharmacology 20051228

Title: MD-354 potentiates the antinociceptive effect of clonidine in the mouse tail-flick but not hot-plate assay.

Journal: European journal of pharmacology 20040714

Title: Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG).

Journal: Bioorganic & medicinal chemistry letters 20030324

Title: Electrostatic potential surfaces of 5-HT(3)R agonists suggest accessory cation-pi site adjacent to agonist binding domain.

Journal: Bioorganic & medicinal chemistry letters 20021007

Title: The binding of arylguanidines at 5-HT(3) serotonin receptors: a structure-affinity investigation.

Journal: Bioorganic & medicinal chemistry letters 20010618

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SDS
Tags:6145-41-1 Molecular Formula|6145-41-1 MDL|6145-41-1 SMILES|6145-41-1 1-(3-Chlorophenyl)guanidine