Title: The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1.
Journal: Biochemical pharmacology 20120515
Title: CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans.
Journal: The pharmacogenomics journal 20120401
Title: Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Extrapolating in vitro metabolic interactions to isolated perfused liver: predictions of metabolic interactions between R-bufuralol, bunitrolol, and debrisoquine.
Journal: Journal of pharmaceutical sciences 20101001
Title: Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: Sympathetic activation in chronic renal failure.
Journal: Journal of the American Society of Nephrology : JASN 20090501
Title: Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity.
Journal: Pharmacogenomics 20090101
Title: Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver.
Journal: Biochemical pharmacology 20081001
Title: Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers.
Journal: Pharmacogenomics 20080701
Title: Chimeric mice with humanized liver.
Journal: Toxicology 20080403
Title: The effect of a long term epidural infusion of ropivacaine on CYP2D6 activity.
Journal: Anesthesia and analgesia 20080101
Title: Metabolism of antidepressant and neuroleptic drugs by cytochrome p450s: clinical and interethnic aspects.
Journal: Clinical pharmacology and therapeutics 20071101
Title: Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070801
Title: No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients.
Journal: European journal of clinical pharmacology 20070501
Title: Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping.
Journal: European journal of clinical pharmacology 20070401
Title: In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.
Journal: Journal of pharmaceutical sciences 20070201
Title: Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the 'cocktail' approach.
Journal: Clinical pharmacology and therapeutics 20070201
Title: Genotyping of the cytochrome P450 2D6 4469 C>T polymorphism using SimpleProbes.
Journal: Scandinavian journal of clinical and laboratory investigation 20070101
Title: 3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060901
Title: Liver disease selectively modulates cytochrome P450--mediated metabolism.
Journal: Clinical pharmacology and therapeutics 20060901
Title: Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
Journal: Clinical pharmacology and therapeutics 20060901
Title: Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo.
Journal: European journal of clinical pharmacology 20060701
Title: Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients.
Journal: Journal of clinical pharmacology 20051201
Title: Metabolism of N-hydroxyguanidines (N-hydroxydebrisoquine) in human and porcine hepatocytes: reduction and formation of glucuronides.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20051001
Title: Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction.
Journal: European journal of clinical pharmacology 20050901
Title: Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.
Journal: Proteins 20050501
Title: Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship.
Journal: Clinical chemistry and laboratory medicine 20050101
Title: Assessment of in vivo CYP2D6 activity: differential sensitivity of commonly used probes to urine pH.
Journal: Journal of clinical pharmacology 20041201
Title: The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2.
Journal: Biochemical and biophysical research communications 20041112
Title: In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.
Journal: Clinical pharmacology and therapeutics 20041101
Title: Relationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients.
Journal: Pharmacopsychiatry 20040301
Title: Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1.
Journal: British journal of clinical pharmacology 20040201
Title: Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus.
Journal: Hormone research 20040101
Title: [CYP 2D6 activity profile among patients with depression].
Journal: Psychiatria polska 20040101
Title: The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction.
Journal: Pharmaceutical research 20031001
Title: Effect of ketoconazole on venlafaxine plasma concentrations in extensive and poor metabolisers of debrisoquine.
Journal: European journal of clinical pharmacology 20030901
Title: Disposition of debrisoquine and nortriptyline in Korean subjects in relation to CYP2D6 genotypes, and comparison with Caucasians.
Journal: British journal of clinical pharmacology 20030601
Title: Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype.
Journal: European journal of clinical pharmacology 20030501
Title: Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation.
Journal: Clinical pharmacology and therapeutics 20030501
Title: Interaction of serum proteins with CYP isoforms in human liver microsomes: inhibitory effects of human and bovine albumin, alpha-globulins, alpha-1-acid glycoproteins and gamma-globulins on CYP2C19 and CYP2D6.
Journal: Life sciences 20030314
Title: Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites.
Journal: Clinical pharmacology and therapeutics 20030301
Title: QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.
Journal: Journal of psychopharmacology (Oxford, England) 20021201
Title: Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021101
Title: New allelic arrangement CYP2D6*36 x 2 found in a Japanese poor metabolizer of debrisoquine.
Journal: Pharmacogenetics 20021101
Title: Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients.
Journal: Journal of clinical psychopharmacology 20021001
Title: Is cytochrome P450 CYP2D activity present in pig liver?
Journal: Pharmacology & toxicology 20021001
Title: Catalytic specificity of CYP2D isoforms in rat and human.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020901
Title: 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.
Journal: The Journal of pharmacology and experimental therapeutics 20020601
Title: QTc interval lengthening and debrisoquine metabolic ratio in psychiatric patients treated with oral haloperidol monotherapy.
Journal: European journal of clinical pharmacology 20020601
Title: Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020501
Title: Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19).
Journal: Clinical pharmacology and therapeutics 20020301
Title: Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
Journal: British journal of clinical pharmacology 20020201
Title: The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity.
Journal: Clinical pharmacology and therapeutics 20020101
Title: Effects of terfenadine and diphenhydramine on the CYP2D6 activity in healthy volunteers.
Journal: European journal of drug metabolism and pharmacokinetics 20020101
Title: [Prevalence of ultraextensive drug metabolizers in Croatian population--long-PCR based detection of amplified CYP2D6 gene].
Journal: Lijecnicki vjesnik 20020101
Title: The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.
Journal: Molecular pharmacology 20011201
Title: Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.
Journal: Therapeutic drug monitoring 20011201
Title: The Paton Prize Award. The discovery of the debrisoquine hydroxylation polymorphism: scientific and clinical impact and consequences.
Journal: Toxicology 20011101
Title: An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
Journal: British journal of clinical pharmacology 20011101
Title: Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test.
Journal: Clinical pharmacology and therapeutics 20011001
Title: Heterogeneity of the CYP2D6 gene among Malays in Malaysia.
Journal: Journal of clinical pharmacy and therapeutics 20010601
Title: Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.
Journal: The Biochemical journal 20010415
Title: Moving toward genetic profiling in patient care: the scope and rationale of pharmacogenetic/ecogenetic investigation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010401
Title: Interaction of plasma proteins with cytochromes P450 mediated metabolic reactions: inhibition by human serum albumin and alpha-globulins of the debrisoquine 4-hydroxylation (CYP2D) in liver microsomes of human, hamster and rat.
Journal: Toxicology letters 20010308
Title: Characterization of stereoselectivity and genetic polymorphism of the debrisoquine hydroxylation in man via analysis of urinary debrisoquine and 4-hydroxydebrisoquine by capillary electrophoresis.
Journal: Electrophoresis 19970901
Title: Cyclophosphamide-induced acute liver failure requiring transplantation in a patient with genetically deficient debrisoquine metabolism: a causal relationship?
Journal: Journal of internal medicine 19961101
Title: Thalidomide-induced neuropathy and genetic differences in drug metabolism.
Journal: European journal of clinical pharmacology 19950101
Title: Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: a case report.
Journal: Clinical pharmacology and therapeutics 19930101
Title: Perhexiline maleate-induced hepatitis.
Journal: Hepato-gastroenterology 19910801
Title: Debrisoquine phenotype and the pharmacokinetics and beta-2 receptor pharmacodynamics of metoprolol and its enantiomers.
Journal: The Journal of pharmacology and experimental therapeutics 19910301
Title: Lack of defect in oxidative hydroxylation of debrisoquine in a patient with halothane hepatitis.
Journal: European journal of clinical pharmacology 19900101
Title: Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation.
Journal: Gastroenterology 19830901
Title: Prediction of subclinical perhexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation.
Journal: American heart journal 19830101
Title: Psychiatric side effects of antihypertensive drugs other than reserpine.
Journal: Journal of clinical psychopharmacology 19820201
Title: Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.
Journal: British medical journal (Clinical research ed.) 19820130
Title: Patterns of blood-pressure during chronic administration of postganglionic sympathetic blocking drugs for hypertension.
Journal: Lancet (London, England) 19761113
Title: Exertional hypotension due to postganglionic sympathetic blocking drugs.
Journal: Postgraduate medical journal 19760801
Title: Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure.
Journal: British heart journal 19751001
