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59831-65-1,MFCD00866684
Catalog No.:AA00EBIW

59831-65-1 | Halopemide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
98% by HPLC
in stock  
$179.00   $125.00
- +
10mg
98% by HPLC
in stock  
$258.00   $180.00
- +
25mg
98% by HPLC
in stock  
$473.00   $331.00
- +
50mg
98% by HPLC
in stock  
$761.00   $533.00
- +
100mg
98% by HPLC
in stock  
$1,270.00   $889.00
- +
500mg
98% by HPLC
in stock  
$3,958.00   $2,771.00
- +
1000mg
98% by HPLC
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00EBIW
Chemical Name:
Halopemide
CAS Number:
59831-65-1
Molecular Formula:
C21H22ClFN4O2
Molecular Weight:
416.8764
MDL Number:
MFCD00866684
SMILES:
Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c(=O)[nH]c2c1ccc(c2)Cl
NSC Number:
354856
Properties
Computed Properties
 
Complexity:
593  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.7  

Literature

Title: Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.

Journal: Bioorganic & medicinal chemistry letters 20090401

Title: 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.

Journal: Molecular pharmacology 20090301

Title: Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

Journal: Nature chemical biology 20090201

Title: Optimization of halopemide for phospholipase D2 inhibition.

Journal: Bioorganic & medicinal chemistry letters 20070415

Title: Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment.

Journal: European archives of psychiatry and clinical neuroscience 20041001

Title: Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17.

Title: Neale R, et al. Acute dyskinesias in monkeys elicited by halopemide, mezilamine and the "antidyskinetic" drugs, oxiperomide and tiapride. Psychopharmacology (Berl). 1981;75(3):254-7.

Title: Skafi N, et al. Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease. J Cell Physiol. 2019 Apr;234(4):4825-4839.

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SDS
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Tags:59831-65-1 Molecular Formula|59831-65-1 MDL|59831-65-1 SMILES|59831-65-1 Halopemide
Catalog No.: AA00EBIW
59831-65-1,MFCD00866684
59831-65-1 | Halopemide
Pack Size： 1mg
Purity： ≥98%
in stock
$63.00 $44.00
Pack Size： 5mg
Purity： 98% by HPLC
in stock
$179.00 $125.00
Pack Size： 10mg
Purity： 98% by HPLC
in stock
$258.00 $180.00
Pack Size： 25mg
Purity： 98% by HPLC
in stock
$473.00 $331.00
Pack Size： 50mg
Purity： 98% by HPLC
in stock
$761.00 $533.00
Pack Size： 100mg
Purity： 98% by HPLC
in stock
$1,270.00 $889.00
Pack Size： 500mg
Purity： 98% by HPLC
in stock
$3,958.00 $2,771.00
Pack Size： 1000mg
Purity： 98% by HPLC
in stock
$6,295.00 $4,407.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00EBIW
Chemical Name: Halopemide
CAS Number: 59831-65-1
Molecular Formula: C21H22ClFN4O2
Molecular Weight: 416.8764
MDL Number: MFCD00866684
SMILES: Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c(=O)[nH]c2c1ccc(c2)Cl
NSC Number: 354856
Properties
Complexity: 593  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.7  
Literature fold

Title: Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.

Journal: Bioorganic & medicinal chemistry letters20090401

Title: 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.

Journal: Molecular pharmacology20090301

Title: Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

Journal: Nature chemical biology20090201

Title: Optimization of halopemide for phospholipase D2 inhibition.

Journal: Bioorganic & medicinal chemistry letters20070415

Title: Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment.

Journal: European archives of psychiatry and clinical neuroscience20041001

Title: Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17.

Title: Neale R, et al. Acute dyskinesias in monkeys elicited by halopemide, mezilamine and the "antidyskinetic" drugs, oxiperomide and tiapride. Psychopharmacology (Berl). 1981;75(3):254-7.

Title: Skafi N, et al. Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease. J Cell Physiol. 2019 Apr;234(4):4825-4839.

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