Home Sulfonamines 64984-31-2
64984-31-2,MFCD00181531
Catalog No.:AA00EBJ6

64984-31-2 | 2-Phenylacetylenesulfonamide

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10mg
>98.0%(HPLC)(N)
in stock  
$34.00   $24.00
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100mg
>98.0%(HPLC)(N)
in stock  
$188.00   $132.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00EBJ6
Chemical Name:
2-Phenylacetylenesulfonamide
CAS Number:
64984-31-2
Molecular Formula:
C8H7NO2S
Molecular Weight:
181.2117
MDL Number:
MFCD00181531
SMILES:
NS(=O)(=O)C#Cc1ccccc1
NSC Number:
303580
Properties
Computed Properties
 
Complexity:
295  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.1  

Downstream Synthesis Route

[1]BulletinoftheChemicalSocietyofJapan,1977,vol.50,p.2346-2350

Literature

Title: HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.

Journal: Cancer research 20160501

Title: Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition.

Journal: International journal of biological sciences 20160101

Title: Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20150401

Title: Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis.

Journal: Toxicology and applied pharmacology 20141215

Title: A comparative study of stress-mediated immunological functions with the adjuvanticity of alum.

Journal: The Journal of biological chemistry 20120518

Title: Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance.

Journal: PloS one 20120101

Title: Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function.

Journal: Cancer biology & therapy 20110915

Title: HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

Journal: Molecular cancer research : MCR 20110701

Title: Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age.

Journal: PloS one 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.

Journal: Cancer biology & therapy 20100915

Title: BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain.

Journal: The Journal of biological chemistry 20100129

Title: Sodium orthovanadate inhibits p53-mediated apoptosis.

Journal: Cancer research 20100101

Title: A small molecule inhibitor of inducible heat shock protein 70.

Journal: Molecular cell 20091009

Title: 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.

Journal: Blood 20090806

Title: Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.

Journal: Nature chemical biology 20060901

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Strom E, et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol. 2006 Sep;2(9):474-9. Epub 2006 Jul 23.

Title: Zhou Y, et al. Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70. Oncol Rep. 2017 Jan;37(1):313-322.

Title: Glas M, et al. Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock. 2018 Feb;49(2):229-234.

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