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602306-29-6,MFCD11112135
Catalog No.:AA00ECA0

602306-29-6 | AZD 5438

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$27.00   $19.00
- +
5mg
99%
in stock  
$68.00   $48.00
- +
10mg
99%
in stock  
$100.00   $70.00
- +
50mg
99%
in stock  
$320.00   $224.00
- +
100mg
99%
in stock  
$479.00   $335.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ECA0
Chemical Name:
AZD 5438
CAS Number:
602306-29-6
Molecular Formula:
C18H21N5O2S
Molecular Weight:
371.4566
MDL Number:
MFCD11112135
SMILES:
CC(n1c(C)ncc1c1ccnc(n1)Nc1ccc(cc1)S(=O)(=O)C)C
Properties
Computed Properties
 
Complexity:
556  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.2  

Downstream Synthesis Route
602306-29-6   
C18H26BF2IN2 
 
C36H46BF2N7O2S 

[1]Rodat,Theo;Krebs,Melanie;Döbber,Alexander;Jansen,Björn;Steffen-Heins,Anja;Schwarz,Karin;Peifer,Christian[PhotochemicalandPhotobiologicalSciences,2020,vol.19,#10,p.1319-1325]

C36H46BF2N7O2S 
  602306-29-6 

[1]Rodat,Theo;Krebs,Melanie;Döbber,Alexander;Jansen,Björn;Steffen-Heins,Anja;Schwarz,Karin;Peifer,Christian[PhotochemicalandPhotobiologicalSciences,2020,vol.19,#10,p.1319-1325]

Literature

Title: AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.

Journal: Molecular cancer therapeutics 20090701

Title: Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20081215

Title: The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing.

Journal: Bioorganic & medicinal chemistry letters 20081215

Title: Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20081015

Title: Cyclin-dependent kinase pathways as targets for cancer treatment.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060410

Title: Cyclins and CDKS in development and cancer: lessons from genetically modified mice.

Journal: Frontiers in bioscience : a journal and virtual library 20060101

Title: Mammalian cyclin-dependent kinases.

Journal: Trends in biochemical sciences 20051101

Title: Cyclin D-dependent kinases, INK4 inhibitors and cancer.

Journal: Biochimica et biophysica acta 20020314

Title: Byth KF, et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009 Jul;8(7):1856-66. Epub 2009 Jun 9.

Title: Raghavan P, et al. AZD5438, an Inhibitor of Cdk1, 2, and 9, Enhances the Radiosensitivity of Non-Small Cell Lung Carcinoma Cells. Int J Radiat Oncol Biol Phys. 2012 Jul 12.

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SDS
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