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634911-80-1,MFCD03453073
Catalog No.:AA00ECAE

634911-80-1 | Boc-d-fmk

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1mg
1 week  
$111.00   $78.00
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5mg
1 week  
$226.00   $158.00
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10mg
1 week  
$311.00   $218.00
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25mg
1 week  
$540.00   $378.00
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50mg
1 week  
$783.00   $548.00
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100mg
1 week  
$1,069.00   $748.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ECAE
Chemical Name:
Boc-d-fmk
CAS Number:
634911-80-1
Molecular Formula:
C11H18FNO5
Molecular Weight:
263.2627
MDL Number:
MFCD03453073
SMILES:
CC(C)(C)OC(=O)NC(CC(=O)OC)C(=O)CF
Properties
Computed Properties
 
Complexity:
324  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.9  

Literature

Title: α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling.

Journal: Journal of neurochemistry 20111101

Title: Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling.

Journal: Hearing research 20090901

Title: Pan-caspase inhibition suppresses polyethylene particle-induced osteolysis.

Journal: Apoptosis : an international journal on programmed cell death 20090201

Title: Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge.

Journal: Journal of gastroenterology and hepatology 20080801

Title: New insights into peripherin expression in cochlear neurons.

Journal: Neuroscience 20071130

Title: Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101

Title: Broad-spectrum caspase inhibitors: from myth to reality?

Journal: Cell death and differentiation 20070201

Title: Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications.

Journal: Molecular cancer therapeutics 20070101

Title: Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7.

Journal: Anticancer research 20070101

Title: zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells.

Journal: Experimental & molecular medicine 20061231

Title: Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways.

Journal: Molecular cancer therapeutics 20060901

Title: The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.

Journal: Oncogene 20051020

Title: Inhibition of N-methyl-D-aspartate receptors increases paraoxon-induced apoptosis in cultured neurons.

Journal: Toxicology and applied pharmacology 20051001

Title: Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes.

Journal: Free radical biology & medicine 20050901

Title: Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway.

Journal: Biochemical and biophysical research communications 20050603

Title: Tirapazamine cytotoxicity for neuroblastoma is p53 dependent.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050401

Title: Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.

Journal: Molecular cancer therapeutics 20050301

Title: Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.

Journal: European journal of pharmacology 20041025

Title: A cell-based screen for drugs to treat Huntington's disease.

Journal: Neurobiology of disease 20040801

Title: Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040601

Title: Silica-exposed mice generate autoantibodies to apoptotic cells.

Journal: Toxicology 20040215

Title: Caspase-3 activation in systemic anaplastic large-cell lymphoma.

Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20040101

Title: Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031001

Title: Protein kinase C inhibition induces DNA fragmentation in COLO 205 cells which is blocked by cysteine protease inhibition but not mediated through caspase-3.

Journal: Experimental cell research 20030910

Title: Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties.

Journal: Apoptosis : an international journal on programmed cell death 20030801

Title: Caspase-dependent and -independent apoptosis of mast cells induced by withdrawal of IL-3 is prevented by Toll-like receptor 4-mediated lipopolysaccharide stimulation.

Journal: European journal of immunology 20030801

Title: Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats.

Journal: Experimental neurology 20030601

Title: The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway.

Journal: Cell death and differentiation 20010701

Title: Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species.

Title: Yee SB, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med. 2006 Dec 31;38(6):634-42.

Title: Sheen-Chen SM, et al. Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 1):1276-9.

Title: Chan YM, et al. Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats. Exp Neurol. 2003 Jun;181(2):190-203.

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