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59729-37-2,MFCD00866607
Catalog No.:AA00ECAW

59729-37-2 | Fexinidazole

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
95%
in stock  
$45.00   $32.00
- +
100mg
98%
in stock  
$112.00   $78.00
- +
250mg
98%
in stock  
$170.00   $119.00
- +
1g
98%
in stock  
$359.00   $252.00
- +
5g
98%
in stock  
$1,607.00 $1,125.00
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ECAW
Chemical Name:
Fexinidazole
CAS Number:
59729-37-2
Molecular Formula:
C12H13N3O3S
Molecular Weight:
279.3149
MDL Number:
MFCD00866607
SMILES:
CSc1ccc(cc1)OCc1ncc(n1C)[N+](=O)[O-]
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
305  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.5  

Literature

Title: Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).

Journal: Mutagenesis 20120901

Title: Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.

Journal: Science translational medicine 20120201

Title: Development of novel drugs for human African trypanosomiasis.

Journal: Future microbiology 20110601

Title: 1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.

Journal: European journal of medicinal chemistry 20110501

Title: Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis.

Journal: Bioorganic & medicinal chemistry letters 20110201

Title: Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.

Journal: Current topics in medicinal chemistry 20110101

Title: Potential new drugs for human African trypanosomiasis: some progress at last.

Journal: Current opinion in infectious diseases 20101201

Title: Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.

Journal: PLoS neglected tropical diseases 20101201

Title: Kaiser M, et al. Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness. Antimicrob Agents Chemother. 2011 Dec;55(12):5602-8.

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SDS
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Tags:59729-37-2 Molecular Formula|59729-37-2 MDL|59729-37-2 SMILES|59729-37-2 Fexinidazole
Catalog No.: AA00ECAW
59729-37-2,MFCD00866607
59729-37-2 | Fexinidazole
Pack Size： 25mg
Purity： 95%
in stock
$45.00 $32.00
Pack Size： 100mg
Purity： 98%
in stock
$112.00 $78.00
Pack Size： 250mg
Purity： 98%
in stock
$170.00 $119.00
Pack Size： 1g
Purity： 98%
in stock
$359.00 $252.00
Pack Size： 5g
Purity： 98%
in stock
$1,607.00 $1,125.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA00ECAW
Chemical Name: Fexinidazole
CAS Number: 59729-37-2
Molecular Formula: C12H13N3O3S
Molecular Weight: 279.3149
MDL Number: MFCD00866607
SMILES: CSc1ccc(cc1)OCc1ncc(n1C)[N+](=O)[O-]
Properties
Form: Solid  
Storage: Keep in dry area;Room Temperature;  
Complexity: 305  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.5  
Literature fold

Title: Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).

Journal: Mutagenesis20120901

Title: Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies.

Journal: Bioorganic & medicinal chemistry letters20120715

Title: The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.

Journal: Science translational medicine20120201

Title: Development of novel drugs for human African trypanosomiasis.

Journal: Future microbiology20110601

Title: 1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.

Journal: European journal of medicinal chemistry20110501

Title: Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis.

Journal: Bioorganic & medicinal chemistry letters20110201

Title: Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.

Journal: Current topics in medicinal chemistry20110101

Title: Potential new drugs for human African trypanosomiasis: some progress at last.

Journal: Current opinion in infectious diseases20101201

Title: Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.

Journal: PLoS neglected tropical diseases20101201

Title: Kaiser M, et al. Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness. Antimicrob Agents Chemother. 2011 Dec;55(12):5602-8.

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