62596-29-6,MFCD09953814
Catalog No.:AA00ECMM

62596-29-6 | Morusin

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1mg
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5mg
≥98%
in stock  
$129.00   $90.00
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10mg
≥98%
in stock  
$230.00   $161.00
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20mg
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50mg
≥98%
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$953.00   $667.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ECMM
Chemical Name:
Morusin
CAS Number:
62596-29-6
Molecular Formula:
C25H24O6
Molecular Weight:
420.4545
MDL Number:
MFCD09953814
SMILES:
CC(=CCc1c(oc2c(c1=O)c(O)cc1c2C=CC(O1)(C)C)c1ccc(cc1O)O)C
NSC Number:
649220
Properties
Computed Properties
 
Complexity:
805  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
5.5  

Downstream Synthesis Route

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

[2]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

[3]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

62596-29-6    62596-35-4    64079-95-4    65793-00-2   
2-2,4-Dihydroxy-6-(3-isopropenyl-oxiranyl)-phenyl-5-hydroxy-8,8-dimethyl-8H-pyrano2,3-fchromen-4-one 

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

62596-29-6    64079-95-4    65793-00-2   
2-2,4-Dihydroxy-6-(3-isopropenyl-oxiranyl)-phenyl-5-hydroxy-8,8-dimethyl-8H-pyrano2,3-fchromen-4-one 

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

Literature

Title: Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer.

Journal: Chemico-biological interactions 20180301

Title: Involvement of the antioxidative property of morusin in blocking phorbol ester-induced malignant transformation of JB6 P(+) mouse epidermal cells.

Journal: Chemico-biological interactions 20170225

Title: Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells.

Journal: Toxicology letters 20150122

Title: Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells.

Journal: Archives of pharmacal research 20120101

Title: Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.

Journal: Molecules (Basel, Switzerland) 20110719

Title: Inhibition and structural reliability of prenylated flavones from the stem bark of Morus lhou on β-secretase (BACE-1).

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: Isolation of cholinesterase-inhibiting flavonoids from Morus lhou.

Journal: Journal of agricultural and food chemistry 20110511

Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Journal: International journal of molecular sciences 20110101

Title: Induction of Biologically Active Flavonoids in Cell Cultures of Morus nigra and Testing their Hypoglycemic Efficacy.

Journal: Scientia pharmaceutica 20110101

Title: Cytotoxic prenylated flavonoids from Morus alba.

Journal: Fitoterapia 20101201

Title: Prenylated flavones from Artocarpus altilis.

Journal: Journal of natural medicines 20101001

Title: New isoprenylated flavonoids and cytotoxic constituents from Artocarpus tonkinensis.

Journal: Journal of Asian natural products research 20100701

Title: New isoprenylated flavonoid from Morus alba.

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100601

Title: Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz.

Journal: Journal of enzyme inhibition and medicinal chemistry 20081201

Title: [Studies on chemical constituents from twigs of Morus atropurpurea].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

Title: Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells.

Journal: Biochemical and biophysical research communications 20080718

Title: Phenolic constituents from the wood of Morus australis with cytotoxic activity.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

Title: [Studies on chemical constituents from bark of Morus nigra].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201

Title: [Determination of morusin in cortex mori].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

Title: Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats.

Journal: Journal of ethnopharmacology 20050914

Title: Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20041101

Title: Antinephritis and radical scavenging activity of prenylflavonoids.

Journal: Fitoterapia 20031201

Title: Root turnover: an important source of microbial substrates in rhizosphere remediation of recalcitrant contaminants.

Journal: Environmental science & technology 20020401

Title: Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases.

Journal: Biochemical pharmacology 20011101

Title: Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.

Journal: Anticancer research 20000101

Title: Li H, et al. Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. J Exp Clin Cancer Res. 2015 Nov 4;34:137.

Title: Lee JC, et al. Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Commun. 2008 Jul 18;372(1):236-42.

Title: Lim SL, et al. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. Am J Cancer Res. 2014 Dec 15;5(1):289-99.

Quotation Request
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Additional Info:
SDS
Tags:62596-29-6 Molecular Formula|62596-29-6 MDL|62596-29-6 SMILES|62596-29-6 Morusin
Catalog No.: AA00ECMM
62596-29-6,MFCD09953814
62596-29-6 | Morusin
Pack Size: 1mg
Purity: 95%
in stock
$45.00 $32.00
Pack Size: 5mg
Purity: ≥98%
in stock
$129.00 $90.00
Pack Size: 10mg
Purity: ≥98%
in stock
$230.00 $161.00
Pack Size: 20mg
Purity:
in stock
$415.00 $290.00
Pack Size: 50mg
Purity: ≥98%
in stock
$953.00 $667.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00ECMM
Chemical Name: Morusin
CAS Number: 62596-29-6
Molecular Formula: C25H24O6
Molecular Weight: 420.4545
MDL Number: MFCD09953814
SMILES: CC(=CCc1c(oc2c(c1=O)c(O)cc1c2C=CC(O1)(C)C)c1ccc(cc1O)O)C
NSC Number: 649220
Properties
Complexity: 805  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 5.5  
Downstream Synthesis Route
62596-29-6    732-26-3    65301-60-2    65301-61-3    65301-59-9    65301-58-8 

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

[2]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

[3]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

62596-29-6    62596-35-4    64079-95-4 

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

62596-29-6    62596-35-4    64079-95-4    65793-00-2   
2-2,4-Dihydroxy-6-(3-isopropenyl-oxiranyl)-phenyl-5-hydroxy-8,8-dimethyl-8H-pyrano2,3-fchromen-4-one 

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

62596-29-6    64079-95-4 

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

62596-29-6    64079-95-4    65793-00-2   
2-2,4-Dihydroxy-6-(3-isopropenyl-oxiranyl)-phenyl-5-hydroxy-8,8-dimethyl-8H-pyrano2,3-fchromen-4-one 

[1]JournalofHeterocyclicChemistry,1980,vol.17,p.641-646

Literature fold

Title: Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer.

Journal: Chemico-biological interactions20180301

Title: Involvement of the antioxidative property of morusin in blocking phorbol ester-induced malignant transformation of JB6 P(+) mouse epidermal cells.

Journal: Chemico-biological interactions20170225

Title: Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells.

Journal: Toxicology letters20150122

Title: Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells.

Journal: Archives of pharmacal research20120101

Title: Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.

Journal: Molecules (Basel, Switzerland)20110719

Title: Inhibition and structural reliability of prenylated flavones from the stem bark of Morus lhou on β-secretase (BACE-1).

Journal: Bioorganic & medicinal chemistry letters20110515

Title: Isolation of cholinesterase-inhibiting flavonoids from Morus lhou.

Journal: Journal of agricultural and food chemistry20110511

Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Journal: International journal of molecular sciences20110101

Title: Induction of Biologically Active Flavonoids in Cell Cultures of Morus nigra and Testing their Hypoglycemic Efficacy.

Journal: Scientia pharmaceutica20110101

Title: Cytotoxic prenylated flavonoids from Morus alba.

Journal: Fitoterapia20101201

Title: Prenylated flavones from Artocarpus altilis.

Journal: Journal of natural medicines20101001

Title: New isoprenylated flavonoids and cytotoxic constituents from Artocarpus tonkinensis.

Journal: Journal of Asian natural products research20100701

Title: New isoprenylated flavonoid from Morus alba.

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20100601

Title: Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz.

Journal: Journal of enzyme inhibition and medicinal chemistry20081201

Title: [Studies on chemical constituents from twigs of Morus atropurpurea].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20081101

Title: Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells.

Journal: Biochemical and biophysical research communications20080718

Title: Phenolic constituents from the wood of Morus australis with cytotoxic activity.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20080101

Title: [Studies on chemical constituents from bark of Morus nigra].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20071201

Title: [Determination of morusin in cortex mori].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20070601

Title: Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats.

Journal: Journal of ethnopharmacology20050914

Title: Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20041101

Title: Antinephritis and radical scavenging activity of prenylflavonoids.

Journal: Fitoterapia20031201

Title: Root turnover: an important source of microbial substrates in rhizosphere remediation of recalcitrant contaminants.

Journal: Environmental science & technology20020401

Title: Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases.

Journal: Biochemical pharmacology20011101

Title: Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.

Journal: Anticancer research20000101

Title: Li H, et al. Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. J Exp Clin Cancer Res. 2015 Nov 4;34:137.

Title: Lee JC, et al. Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Commun. 2008 Jul 18;372(1):236-42.

Title: Lim SL, et al. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. Am J Cancer Res. 2014 Dec 15;5(1):289-99.

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