59-63-2,MFCD00865409
Catalog No.:AA00EDG5

59-63-2 | N'-Benzyl-5-methylisoxazole-3-carbohydrazide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$49.00   $34.00
- +
10mg
≥98%
in stock  
$92.00   $64.00
- +
25mg
≥98%
in stock  
$168.00   $117.00
- +
100mg
≥98%
in stock  
$425.00   $297.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00EDG5
Chemical Name:
N'-Benzyl-5-methylisoxazole-3-carbohydrazide
CAS Number:
59-63-2
Molecular Formula:
C12H13N3O2
Molecular Weight:
231.2505
MDL Number:
MFCD00865409
SMILES:
Cc1onc(c1)C(=O)NNCc1ccccc1
NSC Number:
169893
Properties
Computed Properties
 
Complexity:
254  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.5  

Downstream Synthesis Route

[1]GARDNER;WENIS;LEE[Journalofmedicinalandpharmaceuticalchemistry,1960,vol.2,p.133-145]

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-US2908688,1958,A

[1]GARDNER;WENIS;LEE[Journalofmedicinalandpharmaceuticalchemistry,1960,vol.2,p.133-145]

[1]GARDNER;WENIS;LEE[Journalofmedicinalandpharmaceuticalchemistry,1960,vol.2,p.133-145]

[2]Kawase,Yasushi;Yamagishi,Takehiro;Kato,Jun-Ya;Kutsuma,Teruo;Kataoka,Tadashi;Iwakuma,Takeo;Yokomatsu,Tsutomu[Synthesis,2014,vol.46,#4,p.455-464]

[1]GARDNER;WENIS;LEE[Journalofmedicinalandpharmaceuticalchemistry,1960,vol.2,p.133-145]

Literature

Title: Bromo-dragonfly, a psychoactive benzodifuran, is resistant to hepatic metabolism and potently inhibits monoamine oxidase A.

Journal: Toxicology letters 20181001

Title: Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors.

Journal: Journal of biomolecular screening 20120801

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Vitamin B6 treatment of oedema induced by mirtazapine and isocarboxazid.

Journal: Acta psychiatrica Scandinavica 20110701

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Irreversible, non-selective monoamine oxidase inhibitors].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20090416

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Synthesis of novel N-substituted imidazolecarboxylic acid hydrazides as monoamine oxidase inhibitors.

Journal: Farmaco (Societa chimica italiana : 1989) 20050301

Title: [Prolonged hyperthermia after isocarboxazid poisoning].

Journal: Ugeskrift for laeger 20030428

Title: Toxic interaction of venlafaxine and isocarboxazide.

Journal: Lancet (London, England) 19951111

Title: Serotonin syndrome.

Journal: Neurology 19950201

Title: Sertraline and isocarboxazid cause a serotonin syndrome.

Journal: Journal of clinical psychopharmacology 19940401

Title: A trial of isocarboxazid in the treatment of bulimia nervosa.

Journal: Journal of clinical psychopharmacology 19881201

Title: Mania induced by tricyclic-MAOI combination therapy in bipolar treatment-resistant disorder: case reports.

Journal: The Journal of clinical psychiatry 19860101

Title: Mania after withdrawal of isocarboxazid.

Journal: Journal of clinical psychopharmacology 19851201

Title: Side effects of isocarboxazid.

Journal: The Journal of clinical psychiatry 19840701

Title: The importance of dose in isocarboxazid therapy.

Journal: The Journal of clinical psychiatry 19840701

Title: Acute lithium-induced tremor.

Journal: The British journal of psychiatry : the journal of mental science 19830701

Title: Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants.

Journal: The American journal of psychiatry 19820901

Title: Treatment of lithium-induced tremor and familial essential tremor with essential fatty acids.

Journal: Progress in lipid research 19810101

Title: Linoleic acid in the treatment of lithium toxicity and familial tremor.

Journal: Prostaglandins and medicine 19800401

Title: Tricyclic antidepressants and monoamine oxidase inhibitors.

Journal: Archives of general psychiatry 19710601

Title: Effect of certain monoamine oxidase inhibitors on isoproterenol-induced cardiac necrosis in rats.

Journal: Proceedings of the Western Pharmacology Society 19660101

Title: Use of isocarboxazid in hypertensive patients.

Journal: The Journal of new drugs 19660101

Title: MAXWELL DR, et al. Relative activity of some inhibitors of mono-amine oxidase in potentiating the action of tryptamine in vitro and in vivo. Br J Pharmacol Chemother. 1961 Dec;17:310-20.

Quotation Request
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Additional Info:
SDS
Tags:59-63-2 Molecular Formula|59-63-2 MDL|59-63-2 SMILES|59-63-2 N'-Benzyl-5-methylisoxazole-3-carbohydrazide
Catalog No.: AA00EDG5
59-63-2,MFCD00865409
59-63-2 | N'-Benzyl-5-methylisoxazole-3-carbohydrazide
Pack Size: 5mg
Purity: ≥98%
in stock
$49.00 $34.00
Pack Size: 10mg
Purity: ≥98%
in stock
$92.00 $64.00
Pack Size: 25mg
Purity: ≥98%
in stock
$168.00 $117.00
Pack Size: 100mg
Purity: ≥98%
in stock
$425.00 $297.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00EDG5
Chemical Name: N'-Benzyl-5-methylisoxazole-3-carbohydrazide
CAS Number: 59-63-2
Molecular Formula: C12H13N3O2
Molecular Weight: 231.2505
MDL Number: MFCD00865409
SMILES: Cc1onc(c1)C(=O)NNCc1ccccc1
NSC Number: 169893
Properties
Complexity: 254  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.5  
Downstream Synthesis Route
19788-35-3    555-96-4    59-63-2 

[1]GARDNER;WENIS;LEE[Journalofmedicinalandpharmaceuticalchemistry,1960,vol.2,p.133-145]

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-US2908688,1958,A

39499-34-8    59-63-2    101670-68-2 

[1]GARDNER;WENIS;LEE[Journalofmedicinalandpharmaceuticalchemistry,1960,vol.2,p.133-145]

91397-11-4    59-63-2 

[1]GARDNER;WENIS;LEE[Journalofmedicinalandpharmaceuticalchemistry,1960,vol.2,p.133-145]

[2]Kawase,Yasushi;Yamagishi,Takehiro;Kato,Jun-Ya;Kutsuma,Teruo;Kataoka,Tadashi;Iwakuma,Takeo;Yokomatsu,Tsutomu[Synthesis,2014,vol.46,#4,p.455-464]

62438-03-3    59-63-2 

[1]GARDNER;WENIS;LEE[Journalofmedicinalandpharmaceuticalchemistry,1960,vol.2,p.133-145]

Literature fold

Title: Bromo-dragonfly, a psychoactive benzodifuran, is resistant to hepatic metabolism and potently inhibits monoamine oxidase A.

Journal: Toxicology letters20181001

Title: Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors.

Journal: Journal of biomolecular screening20120801

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology20111201

Title: Vitamin B6 treatment of oedema induced by mirtazapine and isocarboxazid.

Journal: Acta psychiatrica Scandinavica20110701

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: [Irreversible, non-selective monoamine oxidase inhibitors].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke20090416

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Synthesis of novel N-substituted imidazolecarboxylic acid hydrazides as monoamine oxidase inhibitors.

Journal: Farmaco (Societa chimica italiana : 1989)20050301

Title: [Prolonged hyperthermia after isocarboxazid poisoning].

Journal: Ugeskrift for laeger20030428

Title: Toxic interaction of venlafaxine and isocarboxazide.

Journal: Lancet (London, England)19951111

Title: Serotonin syndrome.

Journal: Neurology19950201

Title: Sertraline and isocarboxazid cause a serotonin syndrome.

Journal: Journal of clinical psychopharmacology19940401

Title: A trial of isocarboxazid in the treatment of bulimia nervosa.

Journal: Journal of clinical psychopharmacology19881201

Title: Mania induced by tricyclic-MAOI combination therapy in bipolar treatment-resistant disorder: case reports.

Journal: The Journal of clinical psychiatry19860101

Title: Mania after withdrawal of isocarboxazid.

Journal: Journal of clinical psychopharmacology19851201

Title: Side effects of isocarboxazid.

Journal: The Journal of clinical psychiatry19840701

Title: The importance of dose in isocarboxazid therapy.

Journal: The Journal of clinical psychiatry19840701

Title: Acute lithium-induced tremor.

Journal: The British journal of psychiatry : the journal of mental science19830701

Title: Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants.

Journal: The American journal of psychiatry19820901

Title: Treatment of lithium-induced tremor and familial essential tremor with essential fatty acids.

Journal: Progress in lipid research19810101

Title: Linoleic acid in the treatment of lithium toxicity and familial tremor.

Journal: Prostaglandins and medicine19800401

Title: Tricyclic antidepressants and monoamine oxidase inhibitors.

Journal: Archives of general psychiatry19710601

Title: Effect of certain monoamine oxidase inhibitors on isoproterenol-induced cardiac necrosis in rats.

Journal: Proceedings of the Western Pharmacology Society19660101

Title: Use of isocarboxazid in hypertensive patients.

Journal: The Journal of new drugs19660101

Title: MAXWELL DR, et al. Relative activity of some inhibitors of mono-amine oxidase in potentiating the action of tryptamine in vitro and in vivo. Br J Pharmacol Chemother. 1961 Dec;17:310-20.

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