Name: Name:2-Methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanoic acid
Brand: AABLOCKS
SKU: AA00EFRN
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00EFRN

Chemical Name: 2-Methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanoic acid

CAS Number: 605680-62-4

Molecular Formula: C10H10F3NO3

Molecular Weight: 249.1865

MDL Number: MFCD11035896

SMILES: OC(=O)C(Oc1ccc(cn1)C(F)(F)F)(C)C

Properties

Form: Solid

Storage: Keep in dry area;2-8℃;

Complexity: 291

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 17

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 2.2

Downstream Synthesis Route

605680-62-4

N-3-(4-chlorophenyl)-1(S)-methyl-2(S)-phenylpropyl-aminehydrochloride

N-(1S,2S)-3-(4-chlorophenyl)-1-methyl-2-phenyl-propyl-2-(5-trifluoromethylpyridyloxy)-2-methylpropanamide

[1]Lin,LinusS.;LanzaJr.,ThomasJ.;Jewell,JamesP.;Liu,Fing;Shah,ShrenikK.;Qi,Hongbo;Tong,Xinchun;Wang,Junying;Xu,SuoyuS.;Fong,TungM.;Shen,Chun-Pyn;Lao,Julie;Xiao,JingChen;Shearman,LaurenP.;Stribling,D.Sloan;Rosko,Kimberly;Strack,Alison;Marsh,DonaldJ.;Feng,Yue;Kumar,Sanjeev;Samuel,Koppara;Yin,Wenji;VanDerPloeg,LexH.T.;Goulet,MarkT.;Hagmann,WilliamK.[JournalofMedicinalChemistry,2006,vol.49,#26,p.7584-7587]

605680-62-4

N-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropylaminehydrochloride

701977-09-5

N-(1R,2R)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl-2-methyl-2-5-(trifluoromethyl)pyridin-2-yloxy}propanamide

[1]Lin,LinusS.;LanzaJr.,ThomasJ.;Jewell,JamesP.;Liu,Fing;Shah,ShrenikK.;Qi,Hongbo;Tong,Xinchun;Wang,Junying;Xu,SuoyuS.;Fong,TungM.;Shen,Chun-Pyn;Lao,Julie;Xiao,JingChen;Shearman,LaurenP.;Stribling,D.Sloan;Rosko,Kimberly;Strack,Alison;Marsh,DonaldJ.;Feng,Yue;Kumar,Sanjeev;Samuel,Koppara;Yin,Wenji;VanDerPloeg,LexH.T.;Goulet,MarkT.;Hagmann,WilliamK.[JournalofMedicinalChemistry,2006,vol.49,#26,p.7584-7587]

913849-17-9

605680-62-4

[1]Lin,LinusS.;LanzaJr.,ThomasJ.;Jewell,JamesP.;Liu,Fing;Shah,ShrenikK.;Qi,Hongbo;Tong,Xinchun;Wang,Junying;Xu,SuoyuS.;Fong,TungM.;Shen,Chun-Pyn;Lao,Julie;Xiao,JingChen;Shearman,LaurenP.;Stribling,D.Sloan;Rosko,Kimberly;Strack,Alison;Marsh,DonaldJ.;Feng,Yue;Kumar,Sanjeev;Samuel,Koppara;Yin,Wenji;VanDerPloeg,LexH.T.;Goulet,MarkT.;Hagmann,WilliamK.[JournalofMedicinalChemistry,2006,vol.49,#26,p.7584-7587]

[2]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-WO2012/14221,2012,A1Locationinpatent:Page/Pagecolumn15-17

[3]CurrentPatentAssignee:MERCK&COINC-WO2006/119260,2006,A2Locationinpatent:Page/Pagecolumn35

913849-17-9

605680-62-4

605681-37-6

[1]CurrentPatentAssignee:MERCK&COINC-WO2007/136571,2007,A1Locationinpatent:Page/Pagecolumn44-45

605680-62-4

615560-23-1

721430-07-5

[1]CurrentPatentAssignee:MERCK&COINC-WO2007/136571,2007,A1Locationinpatent:Page/Pagecolumn46-47

605680-62-4 | 2-Methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanoic acid