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5652-28-8,MFCD00014350
Catalog No.:AA00EJNL

5652-28-8 | (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

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50mg
≥95%
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$53.00   $37.00
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100mg
≥95%
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00EJNL
Chemical Name:
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
CAS Number:
5652-28-8
Molecular Formula:
C3H8NO5P
Molecular Weight:
169.0731
MDL Number:
MFCD00014350
SMILES:
OC(=O)C(CP(=O)(O)O)N
Properties
Computed Properties
 
Complexity:
174  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-5.2  

Literature

Title: The genes and enzymes of phosphonate metabolism by bacteria, and their distribution in the marine environment.

Journal: Frontiers in microbiology 20120101

Title: Bacterial predators possess unique membrane lipid structures.

Journal: Lipids 20111201

Title: A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

Journal: Journal of medicinal chemistry 20100513

Title: Wallerian-like axonal degeneration in the optic nerve after excitotoxic retinal insult: an ultrastructural study.

Journal: BMC neuroscience 20100101

Title: Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice.

Journal: Journal of neurochemistry 20091101

Title: Expression of the phosphonoalanine-degradative gene cluster from Variovorax sp. Pal2 is induced by growth on phosphonoalanine and phosphonopyruvate.

Journal: FEMS microbiology letters 20090301

Title: Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity.

Journal: Molecular pain 20090101

Title: Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch.

Journal: Toxicon : official journal of the International Society on Toxinology 20071215

Title: New ways to break an old bond: the bacterial carbon-phosphorus hydrolases and their role in biogeochemical phosphorus cycling.

Journal: Environmental microbiology 20071001

Title: Long-term, repeated dose in vitro neurotoxicity of the glutamate receptor antagonist L-AP3, demonstrated in rat hippocampal slice cultures by using continuous propidium iodide incubation.

Journal: Alternatives to laboratory animals : ATLA 20070501

Title: The molecular basis of glyphosate resistance by an optimized microbial acetyltransferase.

Journal: The Journal of biological chemistry 20070413

Title: Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake.

Journal: Neuroscience research 20050901

Title: Effect of glutamate receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats.

Journal: British journal of pharmacology 20050701

Title: Expression and functional properties of group I metabotropic glutamate receptors in bovine chromaffin cells.

Journal: Journal of neuroscience research 20040115

Title: Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201

Title: Group I mGluR ligands fail to affect 6-hydroxydopamine- induced death and glutamate release of PC12 cells.

Journal: Acta pharmacologica Sinica 20030701

Title: A microdialysis study of glutamate concentration in the hippocampus of rats after TsTX toxin injection and blockade of toxin effects by glutamate receptor antagonists.

Journal: Pharmacology, biochemistry, and behavior 20030101

Title: Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase.

Journal: The Journal of biological chemistry 20021129

Title: Multisubstrate analogue inhibitors of glucosamine-6-phosphate synthase from Candida albicans.

Journal: Bioorganic & medicinal chemistry letters 20020916

Title: L-AP3 blocks rises in intracellular calcium associated with hippocampal CA1 LTP.

Journal: Neuroreport 20020507

Title: The role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E(2) or zymosan in the rat.

Journal: Pain 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Neurotoxic effect of high dose of L-(+)-2-amino-3-phosphonopropionic acid in rats after intracaudatal injection.

Journal: Acta pharmacologica Sinica 20010601

Title: Effects of glutamate receptor antagonists on spinal dorsal horn neurons during zymosan-induced inflammation in rats.

Journal: The journal of pain : official journal of the American Pain Society 20010201

Title: Central activity of 2-amino-3-phosphonopropionic acid (AP3) and its N-methyl analog.

Journal: Polish journal of pharmacology 19940101

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Tags:5652-28-8 Molecular Formula|5652-28-8 MDL|5652-28-8 SMILES|5652-28-8 (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST