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58109-34-5,MFCD00871513
Catalog No.:AA00EK8D

58109-34-5 | 1,1,3,3,3-pentafluoro-2-(fluoromethoxy)prop-1-ene

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10mg
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$1,577.00   $1,104.00
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25mg
95%
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$2,693.00   $1,885.00
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100mg
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$4,479.00   $3,135.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EK8D
Chemical Name:
1,1,3,3,3-pentafluoro-2-(fluoromethoxy)prop-1-ene
CAS Number:
58109-34-5
Molecular Formula:
C4H2F6O
Molecular Weight:
180.0485
MDL Number:
MFCD00871513
SMILES:
FCOC(=C(F)F)C(F)(F)F
Properties
Computed Properties
 
Complexity:
155  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
7  
Rotatable Bond Count:
2  
XLogP3:
2.2  

Literature

Title: Novel involvement of leukotriene B₄ receptor 2 through ERK activation by PP2A down-regulation in leukotriene B₄-induced keratin phosphorylation and reorganization of pancreatic cancer cells.

Journal: Biochimica et biophysica acta 20121201

Title: Sofnolime with different water content causes different effects in two sevoflurane inhalational induction techniques with respect to the output of compound-A.

Journal: International journal of medical sciences 20120101

Title: Degradation products of different water content sevoflurane in carbon dioxide absorbents by gas chromatography-mass spectrometry analysis.

Journal: Chinese medical journal 20110401

Title: [Analysis of sevoflurane stability during low flow anesthesia].

Journal: Anesteziologiia i reanimatologiia 20110101

Title: A comparison between vital capacity induction and tidal breathing induction techniques for the induction of anesthesia and compound A production.

Journal: Chinese medical journal 20100901

Title: Performance of four carbon dioxide absorbents in experimental and clinical settings.

Journal: Anaesthesia 20090301

Title: Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw.

Journal: Journal of neuroscience methods 20080215

Title: Microwave-assisted extraction of active pharmaceutical ingredient from solid dosage forms.

Journal: Journal of chromatography. A 20070713

Title: Compound A, formaldehyde and methanol concentrations during low-flow sevoflurane anaesthesia: comparison of three carbon dioxide absorbers.

Journal: Acta anaesthesiologica Scandinavica 20070501

Title: Inhibition of human immunodeficiency virus envelope glycoprotein- mediated single cell lysis by low-molecular-weight antagonists of viral entry.

Journal: Journal of virology 20070101

Title: Compound A and carbon monoxide production from sevoflurane and seven different types of carbon dioxide absorbent in a patient model.

Journal: Acta anaesthesiologica Scandinavica 20070101

Title: Pathophysiological role of endothelin in ectopic ossification of human spinal ligaments induced by mechanical stress.

Journal: Calcified tissue international 20061201

Title: Novel approach to DPI carrier lactose with mechanofusion process with additives and evaluation by IGC.

Journal: Chemical & pharmaceutical bulletin 20061101

Title: In vitro and in vivo CYP3A64 induction and inhibition studies in rhesus monkeys: a preclinical approach for CYP3A-mediated drug interaction studies.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060901

Title: Nicotine, but neither the alpha4beta2 ligand RJR2403 nor an alpha7 nAChR subtype selective agonist, protects against a partial 6-hydroxydopamine lesion of the rat median forebrain bundle.

Journal: Neuropharmacology 20060901

Title: Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ('compound A') in rats.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060401

Title: Influence of sevoflurane on the metabolism and renal effects of compound A in rats.

Journal: Anesthesiology 20051201

Title: Formation and toxicity of anesthetic degradation products.

Journal: Annual review of pharmacology and toxicology 20050101

Title: Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.

Journal: Chemical research in toxicology 20040901

Title: Comparison of the effects of perfusion in determining brain penetration (brain-to-plasma ratios) of small molecules in rats.

Journal: Comparative medicine 20040801

Title: Production of compound A and carbon monoxide in circle systems: an in vitro comparison of two carbon dioxide absorbents.

Journal: Anaesthesia 20040601

Title: Cytochrome P450 2C8 (CYP2C8)-mediated hydroxylation of an endothelin ETA receptor antagonist in human liver microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040501

Title: A comparison of the effects of prolonged (>10 hour) low-flow sevoflurane, high-flow sevoflurane, and low-flow isoflurane anaesthesia on hepatorenal function in orthopaedic patients.

Journal: Anaesthesia and intensive care 20040401

Title: Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).

Journal: Chemical research in toxicology 20040301

Title: Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors.

Journal: Biology of reproduction 20040201

Title: Amsorb Plus and Drägersorb Free, two new-generation carbon dioxide absorbents that produce a low compound A concentration while providing sufficient CO2 absorption capacity in simulated sevoflurane anesthesia.

Journal: Journal of anesthesia 20040101

Title: Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.

Journal: Toxicology and applied pharmacology 20031115

Title: Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven.

Journal: Anesthesiology 20030901

Title: Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats.

Journal: European journal of pharmacology 20030815

Title: Toxicity of compound A to C6 rat glioma cells.

Journal: Metabolic brain disease 20030301

Title: Sevoflurane degradation by carbon dioxide absorbents may produce more than one nephrotoxic compound in rats.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20030301

Title: Halogenated inhalational anaesthetics.

Journal: Best practice & research. Clinical anaesthesiology 20030301

Title: Computational and experimental studies on the distribution of addition and substitution products of the microsomal glutathione transferase 1-catalyzed conjugation of glutathione with fluoroalkenes.

Journal: Chemical research in toxicology 20030201

Title: Compound A concentration in the circle absorber system during low-flow sevoflurane anesthesia: comparison of Drägersorb Free, Amsorb, and Sodasorb II.

Journal: Journal of clinical anesthesia 20030201

Title: Novel radiator for carbon dioxide absorbents in low-flow anesthesia.

Journal: Annals of clinical and laboratory science 20030101

Title: No compound a formation with Superia during minimal-flow sevoflurane anesthesia: a comparison with Sofnolime.

Journal: Anesthesia and analgesia 20021201

Title: Sevoflurane low-flow anaesthesia: best strategy to reduce Compound A concentration.

Journal: Acta anaesthesiologica Scandinavica 20020901

Title: Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency.

Journal: Anesthesiology 20020901

Title: Reactive intermediate formation from the 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived cysteine S-conjugate S-[2-(Fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-L-cysteine in pyridoxal model systems.

Journal: Chemical research in toxicology 20020501

Title: Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020201

Title: Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.

Journal: Anesthesiology 20020101

Title: Nephrotoxicity of halogenated inhalational anaesthetics: fictions and facts.

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20020101

Title: Methods for assessing endothelin ETA-receptor antagonists in preclinical studies.

Journal: Methods and findings in experimental and clinical pharmacology 20020101

Title: Clinical experience with substance P receptor (NK1) antagonists in depression.

Journal: The Journal of clinical psychiatry 20020101

Title: Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.

Journal: Journal of pharmacological and toxicological methods 20020101

Title: Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function.

Journal: Anesthesia and analgesia 20011201

Title: Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.

Journal: Toxicology and applied pharmacology 20011201

Title: Humoral immune response to a sevoflurane degradation product in the guinea pig following inhalation exposure.

Journal: Drug and chemical toxicology 20011101

Title: Toxicity of a sevoflurane degradation product incubated with rat liver and renal cortical slices.

Journal: Drug and chemical toxicology 20011101

Title: Comparison of plasma alpha glutathione S-transferase concentrations during and after low-flow sevoflurane or isoflurane anaesthesia.

Journal: Acta anaesthesiologica Scandinavica 20011101

Title: Only carbon dioxide absorbents free of both NaOH and KOH do not generate compound A during in vitro closed-system sevoflurane: evaluation of five absorbents.

Journal: Anesthesiology 20010901

Title: Lack of degradation of sevoflurane by a new carbon dioxide absorbent in humans.

Journal: Anesthesiology 20010601

Title: Composition of CO(2) absorbents.

Journal: Anesthesia and analgesia 20010501

Title: Compound A: does it matter?

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010501

Title: Production of compound A under low-flow anesthesia is affected by type of anesthetic machine.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010501

Title: The effects of low-flow sevoflurane and isoflurane anesthesia on renal function in patients with stable moderate renal insufficiency.

Journal: Anesthesia and analgesia 20010301

Title: Metalloprotease inhibitor-mediated inhibition of mouse immunoglobulin production.

Journal: Immunology 20010301

Title: [Low alkali-hydroxide content in soda limes does not lead to reduction of compound A formation from sevoflurane during low-flow anesthesia].

Journal: Der Anaesthesist 20010301

Title: Compound A production from sevoflurane is not less when KOH-free absorbent is used in a closed-circuit lung model system.

Journal: British journal of anaesthesia 20010301

Title: Quantitative determination of vapor-phase compound A in sevoflurane anesthesia using gas chromatography-mass spectrometry.

Journal: Clinical chemistry 20010201

Title: Effects of probenecid on renal function in surgical patients anesthetized with low-flow sevoflurane.

Journal: Anesthesiology 20010101

Title: Renal toxicity with sevoflurane: a storm in a teacup?

Journal: Drugs 20010101

Title: Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats.

Journal: Anesthesiology 19980601

Title: Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers.

Journal: Anesthesia and analgesia 19971101

Title: Quantitative differences in the production and toxicity of CF2=BrCl versus CH2F-O-C(=CF2)(CF3) (compound A): the safety of halothane does not indicate the safety of sevoflurane.

Journal: Anesthesia and analgesia 19971101

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Tags:58109-34-5 Molecular Formula|58109-34-5 MDL|58109-34-5 SMILES|58109-34-5 1,1,3,3,3-pentafluoro-2-(fluoromethoxy)prop-1-ene