Home Other Building Blocks 656247-17-5
656247-17-5,MFCD11974012
Catalog No.:AA00FBWQ

656247-17-5 | BIBF 1120

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
99+%
in stock  
$7.00   $5.00
- +
100mg
99+%
in stock  
$12.00   $8.00
- +
250mg
99+%
in stock  
$17.00   $12.00
- +
1g
99+%
in stock  
$45.00   $32.00
- +
5g
99+%
in stock  
$154.00   $108.00
- +
25g
99+%
in stock  
$542.00   $380.00
- +
100g
99+%
in stock  
$1,355.00   $949.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FBWQ
Chemical Name:
BIBF 1120
CAS Number:
656247-17-5
Molecular Formula:
C31H33N5O4
Molecular Weight:
539.6248
MDL Number:
MFCD11974012
SMILES:
COC(=O)c1ccc2c(c1)NC(=O)/C/2=C(/c1ccccc1)\Nc1ccc(cc1)N(C(=O)CN1CCN(CC1)C)C
Properties
Computed Properties
 
Complexity:
892  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
4.3  

Literature

Title: Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.

Journal: Archives of toxicology 20170101

Title: Nintedanib: A Review of Its Use in Patients with Idiopathic Pulmonary Fibrosis.

Journal: Drugs 20150701

Title: Nintedanib in the treatment of idiopathic pulmonary fibrosis.

Journal: Therapeutic advances in respiratory disease 20150601

Title: Nintedanib: a novel therapeutic approach for idiopathic pulmonary fibrosis.

Journal: Respiratory care 20140901

Title: A new hope for idiopathic pulmonary fibrosis.

Journal: The New England journal of medicine 20140529

Title: Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110401

Title: BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.

Journal: Cancer research 20080615

Title: Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782.

Title: Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480.

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SDS
Tags:656247-17-5 Molecular Formula|656247-17-5 MDL|656247-17-5 SMILES|656247-17-5 BIBF 1120