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Title: Hepatitis C replication inhibitors that target the viral NS4B protein.
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Title: In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor.
Journal: Antimicrobial agents and chemotherapy 20131101
Title: In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons.
Journal: Antiviral research 20131101
Title: Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations.
Journal: Antimicrobial agents and chemotherapy 20130901
Title: Discovery of substituted N-phenylbenzenesulphonamides as a novel class of non-nucleoside hepatitis C virus polymerase inhibitors.
Journal: Antiviral research 20120801
Title: MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Journal: Antimicrobial agents and chemotherapy 20120801
Title: Cellular growth kinetics distinguish a cyclophilin inhibitor from an HSP90 inhibitor as a selective inhibitor of hepatitis C virus.
Journal: PloS one 20120101
Title: The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors.
Journal: The Journal of infectious diseases 20100701
Title: Mechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase.
Journal: The Journal of biological chemistry 20100430
Title: Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Journal: Bioorganic & medicinal chemistry letters 20100401
Title: Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.
Journal: The Journal of biological chemistry 20090605
Title: Substituted imidazopyridines as potent inhibitors of HCV replication.
Journal: Journal of hepatology 20090501
Title: Severe hepatocellular injury with apoptosis induced by a hepatitis C polymerase inhibitor.
Journal: Journal of clinical gastroenterology 20090401
Title: HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus.
Journal: Hepatology (Baltimore, Md.) 20090301
Title: Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.
Journal: Antimicrobial agents and chemotherapy 20080901
Title: Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients.
Journal: The Journal of antimicrobial chemotherapy 20080601
Title: The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors.
Journal: Antimicrobial agents and chemotherapy 20080501
Title: Flint M, et al. Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034). Antimicrob Agents Chemother. 2009 Feb;53(2):401-11.
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