685898-44-6,MFCD11840749
Catalog No.:AA00FBY1

685898-44-6 | L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$95.00   $66.00
- +
10mg
≥95%
in stock  
$168.00   $117.00
- +
25mg
≥95%
in stock  
$370.00   $259.00
- +
50mg
98%
in stock  
$467.00   $327.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00FBY1
Chemical Name:
L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1
CAS Number:
685898-44-6
Molecular Formula:
C13H20Cl4N2O3
Molecular Weight:
394.1215
MDL Number:
MFCD11840749
SMILES:
ClCC[N+](c1ccc(cc1)C[C@@H](C(=O)O)N)(CCCl)[O-].Cl.Cl
Properties
Computed Properties
 
Complexity:
304  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  

Literature

Title: Nickel ions bind to HSP90β and enhance HIF-1α-mediated IL-8 expression.

Journal: Toxicology 20180215

Title: Retinoic acid signalling is activated in the postischemic heart and may influence remodelling.

Journal: PloS one 20120101

Title: Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).

Journal: Expert opinion on therapeutic patents 20110201

Title: Treatment with HIF-1alpha antagonist PX-478 inhibits progression and spread of orthotopic human small cell lung cancer and lung adenocarcinoma in mice.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20100701

Title: Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer.

Journal: Molecular cancer therapeutics 20100701

Title: HIF-1alpha and cancer therapy.

Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20100101

Title: Hypoxia-inducible factor in cancer angiogenesis: structure, regulation and clinical perspectives.

Journal: Critical reviews in oncology/hematology 20090501

Title: The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects.

Journal: Molecular cancer therapeutics 20090401

Title: PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells.

Journal: International journal of cancer 20081115

Title: Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha.

Journal: Molecular cancer therapeutics 20080101

Title: Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo.

Journal: NMR in biomedicine 20051101

Title: Hypoxia inducible factor-1: a novel target for cancer therapy.

Journal: Anti-cancer drugs 20051001

Title: New drugs target hypoxia response in tumors.

Journal: Journal of the National Cancer Institute 20050803

Title: Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478.

Journal: Neoplasia (New York, N.Y.) 20050501

Title: Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade.

Journal: Cancer biology & therapy 20040601

Title: Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

Journal: Molecular cancer therapeutics 20040301

Title: Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437.

Title: Agarwal S, et al. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47.

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Related Products of 685898-44-6
Tags:685898-44-6 Molecular Formula|685898-44-6 MDL|685898-44-6 SMILES|685898-44-6 L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1
Catalog No.: AA00FBY1
685898-44-6,MFCD11840749
685898-44-6 | L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1
Pack Size: 5mg
Purity: ≥95%
in stock
$95.00 $66.00
Pack Size: 10mg
Purity: ≥95%
in stock
$168.00 $117.00
Pack Size: 25mg
Purity: ≥95%
in stock
$370.00 $259.00
Pack Size: 50mg
Purity: 98%
in stock
$467.00 $327.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00FBY1
Chemical Name: L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1
CAS Number: 685898-44-6
Molecular Formula: C13H20Cl4N2O3
Molecular Weight: 394.1215
MDL Number: MFCD11840749
SMILES: ClCC[N+](c1ccc(cc1)C[C@@H](C(=O)O)N)(CCCl)[O-].Cl.Cl
Properties
Complexity: 304  
Covalently-Bonded Unit Count: 3  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 22  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 4  
Rotatable Bond Count: 8  
Literature fold

Title: Nickel ions bind to HSP90β and enhance HIF-1α-mediated IL-8 expression.

Journal: Toxicology20180215

Title: Retinoic acid signalling is activated in the postischemic heart and may influence remodelling.

Journal: PloS one20120101

Title: Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).

Journal: Expert opinion on therapeutic patents20110201

Title: Treatment with HIF-1alpha antagonist PX-478 inhibits progression and spread of orthotopic human small cell lung cancer and lung adenocarcinoma in mice.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer20100701

Title: Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer.

Journal: Molecular cancer therapeutics20100701

Title: HIF-1alpha and cancer therapy.

Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer20100101

Title: Hypoxia-inducible factor in cancer angiogenesis: structure, regulation and clinical perspectives.

Journal: Critical reviews in oncology/hematology20090501

Title: The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects.

Journal: Molecular cancer therapeutics20090401

Title: PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells.

Journal: International journal of cancer20081115

Title: Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha.

Journal: Molecular cancer therapeutics20080101

Title: Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo.

Journal: NMR in biomedicine20051101

Title: Hypoxia inducible factor-1: a novel target for cancer therapy.

Journal: Anti-cancer drugs20051001

Title: New drugs target hypoxia response in tumors.

Journal: Journal of the National Cancer Institute20050803

Title: Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478.

Journal: Neoplasia (New York, N.Y.)20050501

Title: Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade.

Journal: Cancer biology & therapy20040601

Title: Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

Journal: Molecular cancer therapeutics20040301

Title: Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437.

Title: Agarwal S, et al. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47.

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