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717824-30-1,MFCD18633262
Catalog No.:AA00FBYG

717824-30-1 | Vidofludimus

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$27.00   $19.00
- +
50mg
98
in stock  
$861.00   $603.00
- +
100mg
98
in stock  
$1,200.00   $840.00
- +
1000mg
98% by HPLC
in stock  
$11,279.00   $7,896.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FBYG
Chemical Name:
Vidofludimus
CAS Number:
717824-30-1
Molecular Formula:
C20H18FNO4
Molecular Weight:
355.3596
MDL Number:
MFCD18633262
SMILES:
COc1cccc(c1)c1ccc(c(c1)F)NC(=O)C1=C(CCC1)C(=O)O
Properties
Computed Properties
 
Complexity:
576  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.4  

Literature

Title: Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: the ENTRANCE study.

Journal: Journal of Crohn's & colitis 20130901

Title: Vidofludimus inhibits colonic interleukin-17 and improves hapten-induced colitis in rats by a unique dual mode of action.

Journal: The Journal of pharmacology and experimental therapeutics 20120901

Title: Immunosuppression with 4SC-101, a novel inhibitor of dihydroorotate dehydrogenase, in a rat model of renal transplantation.

Journal: Transplantation 20120615

Title: Human dihydroorotate dehydrogenase inhibitors, a novel approach for the treatment of autoimmune and inflammatory diseases.

Journal: Arzneimittel-Forschung 20110101

Title: 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease.

Journal: Inflammatory bowel diseases 20101001

Title: New preclinical findings with vidofludimus.

Journal: Immunotherapy 20100701

Title: 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice.

Journal: The American journal of pathology 20100601

Title: Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20060115

Title: SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20051101

Title: Fitzpatrick LR, et al. Vidofludimus inhibits colonic interleukin-17 and improves hapten-induced colitis in rats by a unique dual mode of action. J Pharmacol Exp Ther. 2012 Sep;342(3):850-60.

Title: Fitzpatrick LR, et al. 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2010 Oct;16(10):1763-77.

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