Title: IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.
Journal: Journal of medicinal chemistry20131024
Title: Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine.
Journal: Antimicrobial agents and chemotherapy20131001
Title: DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.
Journal: Journal of medicinal chemistry20130808
Title: Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum.
Journal: Eukaryotic cell20130201
Title: Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR).
Journal: Bioorganic & medicinal chemistry letters20121101
Title: α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation.
Journal: Journal of medicinal chemistry20120726
Title: The isoprenoid-precursor dependence of Plasmodium spp.
Journal: Natural product reports20120701
Title: Crystal structure of Brucella abortus deoxyxylulose-5-phosphate reductoisomerase-like (DRL) enzyme involved in isoprenoid biosynthesis.
Journal: The Journal of biological chemistry20120504
Title: Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents.
Journal: European journal of medicinal chemistry20120501
Title: Changes in the hydrocarbon-synthesizing activity during growth of Botryococcus braunii B70.
Journal: Bioresource technology20120401
Title: Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts.
Journal: Metabolic engineering20120101
Title: Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): a review of the synthesis and biological evaluation of recent inhibitors.
Journal: Current topics in medicinal chemistry20120101
Title: Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.
Journal: Bioorganic & medicinal chemistry letters20111201
Title: Floral odor bouquet loses its ant repellent properties after inhibition of terpene biosynthesis.
Journal: Journal of chemical ecology20111201
Title: Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
Journal: The Journal of organic chemistry20111104
Title: New N-acetyltransferase fold in the structure and mechanism of the phosphonate biosynthetic enzyme FrbF.
Journal: The Journal of biological chemistry20111014
Title: Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr).
Journal: Journal of medicinal chemistry20111013
Title: Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ.
Journal: Chemical communications (Cambridge, England)20110928
Title: Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters20110915
Title: Resistance of the Burkholderia cepacia complex to fosmidomycin and fosmidomycin derivatives.
Journal: International journal of antimicrobial agents20110901
Title: Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.
Journal: PLoS biology20110801
Title: Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
Journal: Journal of medicinal chemistry20110728
Title: Isoprene synthesis in plants: lessons from a transgenic tobacco model.
Journal: Plant, cell & environment20110601
Title: Induction of a longer term component of isoprene release in darkened aspen leaves: origin and regulation under different environmental conditions.
Journal: Plant physiology20110601
Title: A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling.
Journal: Biochemistry20110503
Title: A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr).
Journal: Journal of biomolecular screening20110301
Title: Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors.
Journal: Bioorganic & medicinal chemistry20110201
Title: Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways.
Journal: PloS one20110101
Title: Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites.
Journal: Current topics in medicinal chemistry20110101
Title: Evidence of isoprenoid precursor toxicity in Bacillus subtilis.
Journal: Bioscience, biotechnology, and biochemistry20110101
Title: Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis.
Journal: Proceedings of the National Academy of Sciences of the United States of America20101012
Title: Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin.
Journal: ChemMedChem20101004
Title: Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.
Journal: Journal of structural biology20100601
Title: Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase.
Journal: The Journal of organic chemistry20100521
Title: Effects of fosmidomycin on plant photosynthesis as measured by gas exchange and chlorophyll fluorescence.
Journal: Photosynthesis research20100401
Title: A high-throughput colorimetric-based bioassay method for determination of fosmidomycin in plasma and urine and application for pharmacokinetic study.
Journal: Journal of pharmacological and toxicological methods20100101
Title: The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening.
Journal: Protein and peptide letters20100101
Title: Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Journal: Journal of medicinal chemistry20091112
Title: Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.
Journal: Nature chemical biology20091101
Title: The carotenogenesis pathway via the isoprenoid-beta-carotene interference approach in a new strain of Dunaliella salina isolated from Baja California Mexico.
Journal: Marine drugs20090301
Title: The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells.
Journal: The Plant cell20090101
Title: Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum.
Journal: Genome biology20090101
Title: The biosynthesis and accumulation of beta-carotene in Dunaliella salina proceed via the glyceraldehyde 3-phosphate/pyruvate pathway.
Journal: Natural product research20090101
Title: Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).
Journal: PloS one20090101
Title: Isoprene and nitric oxide reduce damages in leaves exposed to oxidative stress.
Journal: Plant, cell & environment20081201
Title: Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase.
Journal: ChemMedChem20080801
Title: Significance of terpenoids in induced indirect plant defence against herbivorous arthropods.
Journal: Plant, cell & environment20080401
Title: Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
Journal: Chemistry & biodiversity20080401
Title: Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates.
Journal: Bioorganic & medicinal chemistry20080315
Title: Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake.
Journal: BMC microbiology20080101
Title: Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria.
Journal: Malaria journal20080101
Title: gamma-Substituted bis(pivaloyloxymethyl)ester analogues of fosmidomycin and FR900098.
Journal: Archiv der Pharmazie20071201
Title: Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors.
Journal: Bioorganic & medicinal chemistry letters20070901
Title: Assessment of in vitro antimalarial interactions between dihydroartemisinin and fosmidomycin.
Journal: The Southeast Asian journal of tropical medicine and public health20070901
Title: The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: presence and sensitivity to fosmidomycin.
Journal: Experimental parasitology20070801
Title: An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling.
Journal: Microbiology (Reading, England)20070801
Title: Molecular epidemiology of malaria in Cameroon. XXV. In vitro activity of fosmidomycin and its derivatives against fresh clinical isolates of Plasmodium falciparum and sequence analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
Journal: The American journal of tropical medicine and hygiene20070801
Title: Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis.
Journal: The Journal of biological chemistry20070706
Title: Conformationally restrained aromatic analogues of fosmidomycin and FR900098.
Journal: Archiv der Pharmazie20070701
Title: Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin.
Journal: Acta crystallographica. Section F, Structural biology and crystallization communications20070601
Title: Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum.
Journal: Memorias do Instituto Oswaldo Cruz20070601
Title: Divergent strategy for the synthesis of alpha-aryl-substituted fosmidomycin analogues.
Journal: The Journal of organic chemistry20070511
Title: Bioassay for determination of fosmidomycin in plasma and urine: application for pharmacokinetic dose optimisation.
Journal: Journal of microbiological methods20070401
Title: Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria.
Journal: Malaria journal20070101
Title: [Evaluation of in vitro antibacterial activity of fosmidomycin and its derivatives].
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Title: Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.
Journal: Journal of medicinal chemistry20061214
Title: Arylmethyl substituted derivatives of Fosmidomycin: synthesis and antimalarial activity.
Journal: European journal of medicinal chemistry20061201
Title: Isoprenoid biosynthesis in plants - 2C-methyl-D-erythritol-4-phosphate synthase (IspC protein) of Arabidopsis thaliana.
Journal: The FEBS journal20061001
Title: Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098.
Journal: Bioorganic & medicinal chemistry20060801
Title: The relationship between the methyl-erythritol phosphate pathway leading to emission of volatile isoprenoids and abscisic acid content in leaves.
Journal: Plant physiology20060801
Title: Plastid cues posttranscriptionally regulate the accumulation of key enzymes of the methylerythritol phosphate pathway in Arabidopsis.
Journal: Plant physiology20060501
Title: Involvement of 2-C-methyl-D-erythritol-4-phosphate pathway in biosynthesis of aphidicolin-like tetracyclic diterpene of Scoparia dulcis.
Journal: Chemical & pharmaceutical bulletin20060501
Title: Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors.
Journal: Journal of medicinal chemistry20060420
Title: Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
Journal: Bioorganic & medicinal chemistry20060401
Title: Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.
Journal: Bioorganic & medicinal chemistry letters20060401
Title: A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Journal: Chembiochem : a European journal of chemical biology20051001
Title: Fosmidomycin analogues as inhibitors of monoterpenoid indole alkaloid production in Catharanthus roseus cells.
Journal: Phytochemistry20050801
Title: Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity.
Journal: Archiv der Pharmazie20050701
Title: AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase.
Journal: Journal of medicinal chemistry20050519
Title: Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.
Journal: Journal of medicinal chemistry20050505
Title: Isoprene decreases the concentration of nitric oxide in leaves exposed to elevated ozone.
Journal: The New phytologist20050501
Title: [Effects of fosmidomycin and lovastatin treatment on taxol biosynthesis in suspension culture cells of Taxus chinensis].
Journal: Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology20050401
Title: Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.
Journal: The Biochemical journal20050215
Title: The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
Journal: Journal of molecular biology20050107
Title: [Prevalence of nonmevalonate and mevalonate pathways for isoprenoid biosynthesis among bacteria of different systematic groups].
Journal: Mikrobiologiia20050101
Title: [Isoprenoid pigments in representatives of the family Microbacteriaceae].
Journal: Mikrobiologiia20050101
Title: The plastid of Plasmodium spp.: a target for inhibitors.
Journal: Current topics in microbiology and immunology20050101
Title: The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum.
Journal: The Journal of biological chemistry20041210
Title: 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview.
Journal: Bioorganic chemistry20041201
Title: Synthesis and biological evaluation with plant cells of new fosmidomycin analogues containing a benzoxazolone or oxazolopyridinone ring.
Journal: Journal of enzyme inhibition and medicinal chemistry20041201
Title: Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation.
Journal: Bioorganic & medicinal chemistry letters20041101
Title: Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria.
Journal: The Journal of infectious diseases20041101
Title: Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes.
Journal: Journal of the American Chemical Society20040908
Title: Determination of fosmidomycin in human serum and urine by capillary electrophoresis.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20040705
Title: Impact of ozone on monoterpene emissions and evidence for an isoprene-like antioxidant action of monoterpenes emitted by Quercus ilex leaves.
Journal: Tree physiology20040401
Title: Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children.
Journal: The Journal of infectious diseases20040301
Title: Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development.
Journal: The Plant cell20040101
Title: The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs.
Journal: Current pharmaceutical design20040101
Title: Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq.
Journal: BMC plant biology20040101
Title: Methyl palmitate: a novel product of the Medfly (Ceratitis capitata) corpus allatum.
Journal: Insect biochemistry and molecular biology20031201
Title: New antimalarial drugs.
Journal: Angewandte Chemie (International ed. in English)20031110
Title: Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli.
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Title: Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells.
Journal: The Journal of biological chemistry20030718
Title: Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity.
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Title: High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition.
Journal: Journal of biomolecular screening20030601
Title: Fosmidomycin for the treatment of malaria.
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Title: Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
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Title: Natural abundance carbon isotope composition of isoprene reflects incomplete coupling between isoprene synthesis and photosynthetic carbon flow.
Journal: Plant physiology20030401
Title: Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata.
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Title: Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots.
Journal: Biotechnology progress20030101
Title: [Effect of fosfidomycin on development of various infections in mice].
Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]20030101
Title: Alternative pathways of carotenoid biosynthesis in prokaryotes and eukaryotes.
Journal: Doklady. Biochemistry and biophysics20030101
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Title: Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics.
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Title: On-line analysis of the (13)CO(2) labeling of leaf isoprene suggests multiple subcellular origins of isoprene precursors.
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Title: Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units.
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Title: Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis.
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Title: E. coli MEP synthase: steady-state kinetic analysis and substrate binding.
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Title: Isoprene produced by leaves protects the photosynthetic apparatus against ozone damage, quenches ozone products, and reduces lipid peroxidation of cellular membranes.
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Title: Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria.
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Title: 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening.
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Title: Isoprene increases thermotolerance of fosmidomycin-fed leaves.
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