712349-95-6,MFCD11973726
Catalog No.:AA00FD09

712349-95-6 | 3-IODOTHYRONAMINE-[ETHYLAMINO-1,1,2,2-2H4] HYDROCHLORIDE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98% D4
2 weeks  
$3,000.00   $2,100.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00FD09
Chemical Name:
3-IODOTHYRONAMINE-[ETHYLAMINO-1,1,2,2-2H4] HYDROCHLORIDE
CAS Number:
712349-95-6
MDL Number:
MFCD11973726
Properties
Computed Properties
 
Complexity:
244  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3.1  

Literature

Title: Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4.

Journal: Endocrinology 20121101

Title: Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20120921

Title: Mitochondrial F(0) F(1) -ATP synthase is a molecular target of 3-iodothyronamine, an endogenous metabolite of thyroid hormone.

Journal: British journal of pharmacology 20120801

Title: Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.

Journal: The Journal of endocrinology 20120601

Title: 3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice.

Journal: British journal of pharmacology 20120501

Title: Induction of torpor: mimicking natural metabolic suppression for biomedical applications.

Journal: Journal of cellular physiology 20120401

Title: ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation.

Journal: The Journal of biological chemistry 20120113

Title: Detection of 3-iodothyronamine in human patients: a preliminary study.

Journal: The Journal of clinical endocrinology and metabolism 20120101

Title: Revisiting thyroid hormones in schizophrenia.

Journal: Journal of thyroid research 20120101

Title: LTI models for 3-iodothyronamine time dynamics: a multiscale view.

Journal: IEEE transactions on bio-medical engineering 20111201

Title: Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.

Journal: Bioorganic & medicinal chemistry 20111201

Title: 3-Iodothyronamine metabolism and functional effects in FRTL5 thyroid cells.

Journal: Journal of molecular endocrinology 20110801

Title: Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusion.

Journal: Cardiovascular drugs and therapy 20110801

Title: Effects of the thyroid hormone derivatives 3-iodothyronamine and thyronamine on rat liver oxidative capacity.

Journal: Molecular and cellular endocrinology 20110720

Title: Evidence for extrathyroidal formation of 3-iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay.

Journal: The Journal of clinical endocrinology and metabolism 20110601

Title: Endogenous 3-iodothyronamine (T1AM): more than we bargained for.

Journal: The Journal of clinical endocrinology and metabolism 20110601

Title: Sustained torpidity following multi-dose administration of 3-iodothyronamine in mice.

Journal: Journal of cellular physiology 20110401

Title: Thyronamines--past, present, and future.

Journal: Endocrine reviews 20110201

Title: Nongenomic signaling pathways triggered by thyroid hormones and their metabolite 3-iodothyronamine on the cardiovascular system.

Journal: Journal of cellular physiology 20110101

Title: The central effects of thyroid hormones on appetite.

Journal: Journal of thyroid research 20110101

Title: Primary and secondary thyroid hormone transporters.

Journal: Thyroid research 20110101

Title: Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.

Journal: PloS one 20110101

Title: Tissue distribution and cardiac metabolism of 3-iodothyronamine.

Journal: Endocrinology 20101001

Title: An online solid-phase extraction-liquid chromatography-tandem mass spectrometry method to study the presence of thyronamines in plasma and tissue and their putative conversion from 13C6-thyroxine.

Journal: The Journal of endocrinology 20100901

Title: Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.

Journal: Molecular bioSystems 20100801

Title: 3-Iodothyronamine (T(1)AM): a new chapter of thyroid hormone endocrinology?

Journal: Molecular bioSystems 20100801

Title: Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice.

Journal: Journal of neuroscience research 20100701

Title: Cardiac effects of thyronamines.

Journal: Heart failure reviews 20100301

Title: Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake.

Journal: Diabetes 20100201

Title: Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates.

Journal: PloS one 20100101

Title: Modulation of cardiac ionic homeostasis by 3-iodothyronamine.

Journal: Journal of cellular and molecular medicine 20090901

Title: Central effects of thyronamines on glucose metabolism in rats.

Journal: The Journal of endocrinology 20090601

Title: Identification and characterization of 3-iodothyronamine intracellular transport.

Journal: Endocrinology 20090401

Title: The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)).

Journal: ACS chemical biology 20090320

Title: The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents.

Journal: Diabetes, obesity & metabolism 20090301

Title: Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team?

Journal: Endocrinology 20090301

Title: Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo.

Journal: Chembiochem : a European journal of chemical biology 20090126

Title: Thyroid hormone analogs and metabolites: new applications for an old hormone?

Journal: Nature clinical practice. Endocrinology & metabolism 20090101

Title: Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum.

Journal: Journal of chromatography. A 20081107

Title: Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors.

Journal: European journal of pharmacology 20080610

Title: Toward deciphering the code to aminergic G protein-coupled receptor drug design.

Journal: Chemistry & biology 20080401

Title: 3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20080201

Title: Metabolic effects of thyroid hormone derivatives.

Journal: Thyroid : official journal of the American Thyroid Association 20080201

Title: Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.

Journal: The Journal of clinical investigation 20071203

Title: Trace amine-associated receptor 1-Family archetype or iconoclast?

Journal: Pharmacology & therapeutics 20071201

Title: Central nervous system regulation of mammalian hibernation: implications for metabolic suppression and ischemia tolerance.

Journal: Journal of neurochemistry 20070901

Title: Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury.

Journal: Stroke 20070901

Title: Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1.

Journal: Journal of medicinal chemistry 20070614

Title: Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070501

Title: Thyronamines are substrates for human liver sulfotransferases.

Journal: Endocrinology 20070401

Title: Trace amine-associated receptors and their ligands.

Journal: British journal of pharmacology 20061201

Title: Rapid modulation of TRH-like peptides in rat brain by thyroid hormones.

Journal: Peptides 20060601

Title: Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.

Journal: Journal of medicinal chemistry 20060209

Title: 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.

Journal: Nature medicine 20040601

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Related Products of 712349-95-6
Tags:712349-95-6 Molecular Formula|712349-95-6 MDL|712349-95-6 SMILES|712349-95-6 3-IODOTHYRONAMINE-[ETHYLAMINO-1,1,2,2-2H4] HYDROCHLORIDE
Catalog No.: AA00FD09
712349-95-6,MFCD11973726
712349-95-6 | 3-IODOTHYRONAMINE-[ETHYLAMINO-1,1,2,2-2H4] HYDROCHLORIDE
Pack Size: 1mg
Purity: 98% D4
2 weeks
$3,000.00 $2,100.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00FD09
Chemical Name: 3-IODOTHYRONAMINE-[ETHYLAMINO-1,1,2,2-2H4] HYDROCHLORIDE
CAS Number: 712349-95-6
MDL Number: MFCD11973726
Properties
Complexity: 244  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 18  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 4  
XLogP3: 3.1  
Literature fold

Title: Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4.

Journal: Endocrinology20121101

Title: Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A20120921

Title: Mitochondrial F(0) F(1) -ATP synthase is a molecular target of 3-iodothyronamine, an endogenous metabolite of thyroid hormone.

Journal: British journal of pharmacology20120801

Title: Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.

Journal: The Journal of endocrinology20120601

Title: 3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice.

Journal: British journal of pharmacology20120501

Title: Induction of torpor: mimicking natural metabolic suppression for biomedical applications.

Journal: Journal of cellular physiology20120401

Title: ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation.

Journal: The Journal of biological chemistry20120113

Title: Detection of 3-iodothyronamine in human patients: a preliminary study.

Journal: The Journal of clinical endocrinology and metabolism20120101

Title: Revisiting thyroid hormones in schizophrenia.

Journal: Journal of thyroid research20120101

Title: LTI models for 3-iodothyronamine time dynamics: a multiscale view.

Journal: IEEE transactions on bio-medical engineering20111201

Title: Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.

Journal: Bioorganic & medicinal chemistry20111201

Title: 3-Iodothyronamine metabolism and functional effects in FRTL5 thyroid cells.

Journal: Journal of molecular endocrinology20110801

Title: Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusion.

Journal: Cardiovascular drugs and therapy20110801

Title: Effects of the thyroid hormone derivatives 3-iodothyronamine and thyronamine on rat liver oxidative capacity.

Journal: Molecular and cellular endocrinology20110720

Title: Evidence for extrathyroidal formation of 3-iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay.

Journal: The Journal of clinical endocrinology and metabolism20110601

Title: Endogenous 3-iodothyronamine (T1AM): more than we bargained for.

Journal: The Journal of clinical endocrinology and metabolism20110601

Title: Sustained torpidity following multi-dose administration of 3-iodothyronamine in mice.

Journal: Journal of cellular physiology20110401

Title: Thyronamines--past, present, and future.

Journal: Endocrine reviews20110201

Title: Nongenomic signaling pathways triggered by thyroid hormones and their metabolite 3-iodothyronamine on the cardiovascular system.

Journal: Journal of cellular physiology20110101

Title: The central effects of thyroid hormones on appetite.

Journal: Journal of thyroid research20110101

Title: Primary and secondary thyroid hormone transporters.

Journal: Thyroid research20110101

Title: Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.

Journal: PloS one20110101

Title: Tissue distribution and cardiac metabolism of 3-iodothyronamine.

Journal: Endocrinology20101001

Title: An online solid-phase extraction-liquid chromatography-tandem mass spectrometry method to study the presence of thyronamines in plasma and tissue and their putative conversion from 13C6-thyroxine.

Journal: The Journal of endocrinology20100901

Title: Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.

Journal: Molecular bioSystems20100801

Title: 3-Iodothyronamine (T(1)AM): a new chapter of thyroid hormone endocrinology?

Journal: Molecular bioSystems20100801

Title: Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice.

Journal: Journal of neuroscience research20100701

Title: Cardiac effects of thyronamines.

Journal: Heart failure reviews20100301

Title: Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake.

Journal: Diabetes20100201

Title: Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates.

Journal: PloS one20100101

Title: Modulation of cardiac ionic homeostasis by 3-iodothyronamine.

Journal: Journal of cellular and molecular medicine20090901

Title: Central effects of thyronamines on glucose metabolism in rats.

Journal: The Journal of endocrinology20090601

Title: Identification and characterization of 3-iodothyronamine intracellular transport.

Journal: Endocrinology20090401

Title: The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)).

Journal: ACS chemical biology20090320

Title: The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents.

Journal: Diabetes, obesity & metabolism20090301

Title: Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team?

Journal: Endocrinology20090301

Title: Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo.

Journal: Chembiochem : a European journal of chemical biology20090126

Title: Thyroid hormone analogs and metabolites: new applications for an old hormone?

Journal: Nature clinical practice. Endocrinology & metabolism20090101

Title: Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum.

Journal: Journal of chromatography. A20081107

Title: Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors.

Journal: European journal of pharmacology20080610

Title: Toward deciphering the code to aminergic G protein-coupled receptor drug design.

Journal: Chemistry & biology20080401

Title: 3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology20080201

Title: Metabolic effects of thyroid hormone derivatives.

Journal: Thyroid : official journal of the American Thyroid Association20080201

Title: Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.

Journal: The Journal of clinical investigation20071203

Title: Trace amine-associated receptor 1-Family archetype or iconoclast?

Journal: Pharmacology & therapeutics20071201

Title: Central nervous system regulation of mammalian hibernation: implications for metabolic suppression and ischemia tolerance.

Journal: Journal of neurochemistry20070901

Title: Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury.

Journal: Stroke20070901

Title: Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1.

Journal: Journal of medicinal chemistry20070614

Title: Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20070501

Title: Thyronamines are substrates for human liver sulfotransferases.

Journal: Endocrinology20070401

Title: Trace amine-associated receptors and their ligands.

Journal: British journal of pharmacology20061201

Title: Rapid modulation of TRH-like peptides in rat brain by thyroid hormones.

Journal: Peptides20060601

Title: Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.

Journal: Journal of medicinal chemistry20060209

Title: 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.

Journal: Nature medicine20040601

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