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69659-80-9,MFCD09028094
Catalog No.:AA00FEG6

69659-80-9 | Sodium tanshinone IIA sulfonate

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1mg
98%
in stock  
$7.00   $5.00
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10mg
98%
in stock  
$14.00   $10.00
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25mg
98%
in stock  
$25.00   $18.00
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50mg
98%
in stock  
$41.00   $29.00
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250mg
98%
in stock  
$120.00   $84.00
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1g
98%
in stock  
$145.00   $102.00
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5g
98%
in stock  
$411.00   $288.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FEG6
Chemical Name:
Sodium tanshinone IIA sulfonate
CAS Number:
69659-80-9
Molecular Formula:
C19H17NaO6S
Molecular Weight:
396.3894
MDL Number:
MFCD09028094
SMILES:
O=C1c2c(ccc3c2CCCC3(C)C)c2c(C1=O)c(C)c(o2)S(=O)(=O)[O-].[Na+]
Properties
Computed Properties
 
Complexity:
742  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
1  

Literature

Title: Sodium tanshinone IIA sulfonate prevents hypoxic trophoblast-induced endothelial cell dysfunction via targeting HMGB1 release.

Journal: Journal of biochemical and molecular toxicology 20170701

Title: Tanshinone IIA protects rabbits against LPS-induced disseminated intravascular coagulation (DIC).

Journal: Acta pharmacologica Sinica 20121001

Title: Anti-PRRSV effect and mechanism of sodium tanshinone IIA sulfonate in vitro.

Journal: Journal of Asian natural products research 20120101

Title: A novel protocol for the preparation of sodium tanshinone sulphonates by direct ultrasound-assisted sulphonation of the crude extract of the roots of Salvia miltiorrhiza Bunge and following counter-current chromatography purification.

Journal: Phytochemical analysis : PCA 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Tanshinone IIA improves impaired nerve functions in experimental diabetic rats.

Journal: Biochemical and biophysical research communications 20100813

Title: Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.

Journal: American journal of respiratory cell and molecular biology 20091201

Title: Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets.

Journal: American journal of physiology. Heart and circulatory physiology 20091001

Title: Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro.

Journal: Experimental & molecular medicine 20090731

Title: Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090701

Title: Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090701

Title: Changes of c-fos and c-jun mRNA expression in angiotensin II-induced cardiomyocyte hypertrophy and effects of sodium tanshinone IIA sulfonate.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081001

Title: Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma/STAT1 pathways.

Journal: Journal of clinical immunology 20080901

Title: Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism.

Journal: Chinese journal of integrative medicine 20080901

Title: Effect of sodium tanshinone II A sulfonate on phosphorylation of extracellular signal-regulated kinase 1/2 in angiotensin II-induced hypertrophy of myocardial cells.

Journal: Chinese journal of integrative medicine 20080601

Title: Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation.

Journal: Journal of cardiovascular pharmacology 20080401

Title: [Changes of c-fos, c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin II and effects of tanshinone II A].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

Title: Determination of sodium tanshinone IIA sulfonate in plasma by liquid chromatography-electrospray ionisation-tandem mass spectrometry.

Journal: Biomedical chromatography : BMC 20071101

Title: Pharmacological activity of cardiovascular agents from herbal medicine.

Journal: Cardiovascular & hematological agents in medicinal chemistry 20071001

Title: Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice.

Journal: Chemical & pharmaceutical bulletin 20070501

Title: A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070315

Title: Ion-pair reversed-phase HPLC: assay validation of sodium tanshinone IIA sulfonate in mouse plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202

Title: Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells.

Journal: Biochemical pharmacology 20020815

Title: Xu QQ, et al. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. Biomed Res Int. 2016;2016:9852536

Title: Jiang Q, et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C136-49.

Title: Ouyang DS, et al. Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chin Med. 2016 Mar 22;11:11.

Title: Chen D, et al. Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica. 2016 Dec;46(12):1085-1092. Epub 2016 Mar 2.

Title: Lin S, et al. [Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):260-4.

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