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714272-27-2,MFCD18074510
Catalog No.:AA00FENP

714272-27-2 | Plinabulin(NPI-2358)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$116.00   $82.00
- +
25mg
98%
in stock  
$275.00   $193.00
- +
50mg
95%
in stock  
$492.00   $344.00
- +
100mg
98%
in stock  
$656.00   $459.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00FENP
Chemical Name:
Plinabulin(NPI-2358)
CAS Number:
714272-27-2
Molecular Formula:
C19H20N4O2
Molecular Weight:
336.3877
MDL Number:
MFCD18074510
SMILES:
O=c1[nH]c(=Cc2nc[nH]c2C(C)(C)C)c(=O)[nH]c1=Cc1ccccc1
Properties
Computed Properties
 
Complexity:
597  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
2.8  

Downstream Synthesis Route
714273-84-4   
CASUnavailable 
  714272-27-2 

[1]CurrentPatentAssignee:OCEANUNIVERSITYOFCHINA-CN114349740,2022,ALocationinpatent:Paragraph0027-0028;0031-0042

[2]CurrentPatentAssignee:SHENZHENHUAHONGMARINEBIOMEDICINE-CN107011331,2017,ALocationinpatent:Paragraph0051;0052

[3]CurrentPatentAssignee:BEYONDSPRINGINC-US2008/221122,2008,A1Locationinpatent:Page/Pagecolumn20;28

[4]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2011/84962,2011,A1Locationinpatent:Page/Pagecolumn38

[5]CurrentPatentAssignee:MARINEBIOMEDICALRESINSTQINGDAO-CN107286139,2017,ALocationinpatent:Paragraph0036;0037

[6]CurrentPatentAssignee:SHENZHENHUAHONGMARINEBIOMEDICINE-CN107011322,2017,ALocationinpatent:Paragraph0029

[1]CurrentPatentAssignee:BEYONDSPRINGINC-US2008/221122,2008,A1Locationinpatent:Page/Pagecolumn20

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2011/84962,2011,A1

[2]CurrentPatentAssignee:BEYONDSPRINGINC-US2008/221122,2008,A1

[3]CurrentPatentAssignee:BEYONDSPRINGINC-US2008/221122,2008,A1

[4]Chen,Huanhuan;Liu,Yuqi;Jiang,Ruonan;Yu,Xinyue;Qin,Mingze;Gong,Ping[ChemicalPapers,2023,vol.77,#7,p.3803-3810]

[5]Chen,Huanhuan;Liu,Yuqi;Jiang,Ruonan;Yu,Xinyue;Qin,Mingze;Gong,Ping[ChemicalPapers,2023,vol.77,#7,p.3803-3810]

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2011/84962,2011,A1

[2]CurrentPatentAssignee:BEYONDSPRINGINC-US2008/221122,2008,A1

[3]CurrentPatentAssignee:BEYONDSPRINGINC-US2008/221122,2008,A1

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2011/84962,2011,A1

[2]CurrentPatentAssignee:BEYONDSPRINGINC-US2008/221122,2008,A1

[3]CurrentPatentAssignee:BEYONDSPRINGINC-US2008/221122,2008,A1

Literature

Title: Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.

Journal: Bioorganic & medicinal chemistry 20120715

Title: Phase 1 study of the novel vascular disrupting agent plinabulin (NPI-2358) and docetaxel.

Journal: Investigational new drugs 20120601

Title: Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.

Journal: Journal of medicinal chemistry 20120209

Title: Vascular disrupting agents (VDA) in oncology: advancing towards new therapeutic paradigms in the clinic.

Journal: Current drug targets 20111201

Title: Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation.

Journal: International journal of radiation biology 20111101

Title: Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.

Journal: Bioorganic & medicinal chemistry 20110101

Title: Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both alpha- and beta-tubulin.

Journal: Bioorganic & medicinal chemistry 20100501

Title: Vascular disrupting agents: a novel mechanism of action in the battle against non-small cell lung cancer.

Journal: The oncologist 20090601

Title: Tubulin-interactive natural products as anticancer agents.

Journal: Journal of natural products 20090301

Title: NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent.

Journal: Anti-cancer drugs 20060101

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