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69097-99-0,MFCD00075646
Catalog No.:AA00FG76

69097-99-0 | (2S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone, 3',5,7-Trihydroxy-4-methoxyflavanone

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00FG76
Chemical Name:
(2S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone, 3',5,7-Trihydroxy-4-methoxyflavanone
CAS Number:
69097-99-0
Molecular Formula:
C16H14O6
Molecular Weight:
302.2788
MDL Number:
MFCD00075646
SMILES:
COc1ccc(cc1O)C1CC(=O)c2c(O1)cc(cc2O)O
FEMA Number:
4313
Properties
Computed Properties
 
Complexity:
413  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.4  

Downstream Synthesis Route

[1]JournalofChemicalResearch,2014,vol.38,p.287-290

[2]Proceedings-IndianAcademyofSciences,SectionA,1949,p.151,157

[3]JournalofMedicinalChemistry,1981,vol.24,p.408-428

Literature

Title: Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II.

Journal: Fitoterapia 20140401

Title: Synthesis and anti-hyperglycemic activity of hesperidin derivatives.

Journal: Bioorganic & medicinal chemistry letters 20121201

Title: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.

Journal: Journal of biomedical science 20110101

Title: Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity.

Journal: Journal of clinical biochemistry and nutrition 20091101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Interaction between hesperetin and human serum albumin revealed by spectroscopic methods.

Journal: Biochimica et biophysica acta 20050620

Title: Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages.

Journal: Journal of cellular physiology 20050201

Title: Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964

Title: Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059.

Title: Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301

Title: Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8.

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SDS
Tags:69097-99-0 Molecular Formula|69097-99-0 MDL|69097-99-0 SMILES|69097-99-0 (2S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone, 3',5,7-Trihydroxy-4-methoxyflavanone