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83805-11-2,MFCD00870595
Catalog No.:AA00G2DW

83805-11-2 | Falecalcitriol

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1mg
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00G2DW
Chemical Name:
Falecalcitriol
CAS Number:
83805-11-2
Molecular Formula:
C27H38F6O3
Molecular Weight:
524.5792
MDL Number:
MFCD00870595
SMILES:
O[C@H]1C[C@H](O)C(=C)/C(=C\C=C\2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](CCCC(C(F)(F)F)(C(F)(F)F)O)C)C)/C1
Properties
Computed Properties
 
Complexity:
860  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
6.6  

Literature

Title: Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial.

Journal: Clinical nephrology 20090601

Title: Vitamin D receptor activators.

Journal: The International journal of artificial organs 20090201

Title: Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambulatory peritoneal dialysis patient.

Journal: Clinical nephrology 20080501

Title: [Long-term suppressive effect of falecalcitriol on parathyroid hormone secretion in secondary hyperparathyroidism in hemodialysis patients].

Journal: Clinical calcium 20060501

Title: Enhanced coactivator binding and transcriptional activation of mutant vitamin D receptors from patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets by phosphorylation and vitamin D analogs.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050901

Title: [Falecalcitriol as a new therapeutic agent for secondary hyperparathyroidism].

Journal: Clinical calcium 20050101

Title: [The trend in the development of the active vitamin D3 and its analogues].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040501

Title: Disposition and metabolism of F6-1alpha,25(OH)2 vitamin D3 and 1alpha,25(OH)2 vitamin D3 in the parathyroid glands of rats dosed with tritium-labeled compounds.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030801

Title: [Pharmacological action and clinical effects of falecalcitriol, a highly potent derivative of active vitamin D3].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021201

Title: A highly potent 26,27-Hexafluoro-1a,25-dihydroxyvitamin D3 on calcification in SV40-transformed human fetal osteoblastic cells.

Journal: Calcified tissue international 20020601

Title: Rationale for use and clinical responsiveness of hexafluoro-1,25-dihydroxyvitamin D3 for the treatment of plaque psoriasis: a pilot study.

Journal: The British journal of dermatology 20010301

Title: Synthesis and biological evaluations of A-ring isomers of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3.

Journal: Bioorganic & medicinal chemistry 20000801

Title: Ito H, Ogata H, Yamamoto M, Takahashi K, Shishido K, Takahashi J, Taguchi S, Kinugasa E. Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial. Clin Nephro

Title: Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y. Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambul

Title: Iwao Y, Yamaguchi Y, Fujii K, Toba Y, Asada M, Nagano N, Yamamoto H, Hyoma K, Yamada S, Hirano H, Tone Y, Ohtani H, Saika Y, Fujii R. Long-term suppressive effect of falecalcitriol on parathyroid hormone secretion in secondary hyperparathyroidism in hemo

Title: Morii H. Falecalcitriol as a new therapeutic agent for secondary hyperparathyroidismClin Calcium. 2005 Jan;15(1):29-33.

Title: Ohtsuka N, Urayama K. Pharmacological action and clinical effects of falecalcitriol, a highly potent derivative of active vitamin D3.Nihon Yakurigaku Zasshi. 2002 Dec;120(6):427-36.

Title: Jean-Pierre Bégué, Danièle Bonnet-Delpon.Recent advances (1995-2005) in fluorinated pharmaceuticals based on natural products. Journal of Fluorine Chemistry.Volume 127, Issue 8, August 2006, Pages 992-1012

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