Title: EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage.
Journal: Toxicology and applied pharmacology 20170115
Title: Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells.
Journal: Toxicology 20160831
Title: Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism.
Journal: Archives of toxicology 20160401
Title: A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression.
Journal: Experimental hematology 20150501
Title: Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway.
Journal: Food & function 20150401
Title: Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes.
Journal: Toxicology and applied pharmacology 20140115
Title: PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons.
Journal: Biochemical and biophysical research communications 20130802
Title: The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs.
Journal: Journal of cellular physiology 20130101
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells.
Journal: Biochemical pharmacology 20121101
Title: Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages.
Journal: The Journal of nutritional biochemistry 20121001
Title: Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts.
Journal: Arthritis and rheumatism 20121001
Title: Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120901
Title: uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells.
Journal: International journal of oncology 20120801
Title: Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.
Journal: The Journal of biological chemistry 20120727
Title: Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells.
Journal: Journal of cellular and molecular medicine 20120701
Title: Ciliogenic RFX transcription factors regulate FGF1 gene promoter.
Journal: Journal of cellular biochemistry 20120701
Title: Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway.
Journal: Biochemical pharmacology 20120701
Title: Rottlerin and curcumin: a comparative analysis.
Journal: Annals of the New York Academy of Sciences 20120701
Title: Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ.
Journal: Behavioural brain research 20120615
Title: Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes.
Journal: Journal of cellular biochemistry 20120601
Title: Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells.
Journal: Oncology reports 20120601
Title: Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC).
Journal: International journal of pharmaceutics 20120530
Title: Differential consequences of protein kinase C activation during early and late hepatic ischemic preconditioning.
Journal: The journal of physiological sciences : JPS 20120501
Title: Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog.
Journal: Molecular and cellular neurosciences 20120501
Title: Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism.
Journal: Chemico-biological interactions 20120415
Title: PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus.
Journal: Biochimica et biophysica acta 20120401
Title: Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor.
Journal: Current eye research 20120301
Title: OX1 orexin/hypocretin receptor activation of phospholipase D.
Journal: British journal of pharmacology 20120201
Title: Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells.
Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120201
Title: Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction.
Journal: Cancer science 20120101
Title: Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation.
Journal: European journal of medicinal chemistry 20120101
Title: Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits.
Journal: Journal of vascular research 20120101
Title: Rottlerin and cancer: novel evidence and mechanisms.
Journal: TheScientificWorldJournal 20120101
Title: Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells.
Journal: Molecular cancer 20120101
Title: Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells.
Journal: Vascular pharmacology 20120101
Title: Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
Journal: Asian Pacific journal of cancer prevention : APJCP 20120101
Title: Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Title: Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK).
Journal: PloS one 20120101
Title: Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells.
Journal: Experimental & molecular medicine 20111231
Title: Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors.
Journal: Endocrine-related cancer 20111201
Title: Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells.
Journal: Journal of cellular and molecular medicine 20111001
Title: Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts.
Journal: Circulation 20110913
Title: Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation.
Journal: Cell biochemistry and biophysics 20110901
Title: Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes.
Journal: Molecular and cellular neurosciences 20110901
Title: Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme.
Journal: Biochimica et biophysica acta 20110901
Title: Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.
Journal: The Journal of biological chemistry 20110826
Title: Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.
Journal: The Journal of biological chemistry 20110805
Title: All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta.
Journal: Journal of leukocyte biology 20110801
Title: Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line.
Journal: Toxicology and applied pharmacology 20110715
Title: High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival.
Journal: Journal of biomolecular screening 20110701
Title: Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer.
Journal: The Journal of clinical investigation 20110701
Title: Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells.
Journal: Environmental toxicology and pharmacology 20110701
Title: Rottlerin exhibits antiangiogenic effects in vitro.
Journal: Chemical biology & drug design 20110601
Title: Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast.
Journal: Biology of reproduction 20110501
Title: Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.
Journal: Free radical biology & medicine 20110501
Title: Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells.
Journal: Carcinogenesis 20110501
Title: EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells.
Journal: Journal of immunotherapy (Hagerstown, Md. : 1997) 20110501
Title: Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells.
Journal: Nutrition research (New York, N.Y.) 20110401
Title: Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells.
Journal: Toxicology letters 20110325
Title: A phospholipase A₂ isolated from Lachesis muta snake venom increases the survival of retinal ganglion cells in vitro.
Journal: Toxicon : official journal of the International Society on Toxinology 20110315
Title: PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures.
Journal: Biochimie 20110201
Title: Targeting transcription through inhibition of TBP.
Journal: Oncotarget 20110201
Title: Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation.
Journal: Chemico-biological interactions 20110115
Title: Interleukin-32α production is regulated by MyD88-dependent and independent pathways in IL-1β-stimulated human alveolar epithelial cells.
Journal: Immunobiology 20110101
Title: Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway.
Journal: PloS one 20110101
Title: PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells.
Journal: Molecular vision 20110101
Title: Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro.
Journal: PloS one 20110101
Title: Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.
Journal: American journal of physiology. Renal physiology 20101201
Title: The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts.
Journal: Arthritis and rheumatism 20101201
Title: Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ.
Journal: Clinical and experimental pharmacology & physiology 20101201
Title: PKC-δ mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner.
Journal: Chemosphere 20101101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP.
Journal: The Journal of biological chemistry 20101008
Title: 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression.
Journal: Toxicology letters 20101005
Title: [Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells].
Journal: Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20101001
Title: Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C.
Journal: Neurotoxicology 20100901
Title: The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells.
Journal: Journal of tissue engineering and regenerative medicine 20100701
Title: PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.
Journal: Journal of the American Society of Nephrology : JASN 20100701
Title: Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}.
Journal: Endocrine-related cancer 20100601
Title: Rottlerin: bases for a possible usage in psoriasis.
Journal: Current drug metabolism 20100601
Title: Rottlerin inhibits migration of follicular thyroid carcinoma cells by PKCdelta-independent destabilization of the focal adhesion complex.
Journal: Journal of cellular biochemistry 20100515
Title: Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells.
Journal: Diabetologia 20100501
Title: Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression.
Journal: Toxicology and applied pharmacology 20100415
Title: Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells.
Journal: FEBS letters 20100305
Title: Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100301
Title: Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells.
Journal: Carcinogenesis 20100301
Title: Inhibition of protein kinase Cdelta reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages.
Journal: European journal of pharmacology 20100225
Title: Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20100101
Title: Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.
Journal: The Journal of steroid biochemistry and molecular biology 20100101
Title: Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells.
Journal: Biochimie 20100101
Title: Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro.
Journal: Molecular immunology 20100101
Title: Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway.
Journal: PloS one 20100101
Title: Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Novel screening method for potential skin-whitening compounds by a luciferase reporter assay.
Journal: Bioscience, biotechnology, and biochemistry 20100101
Title: Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon.
Journal: PloS one 20100101
Title: Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells.
Journal: American journal of physiology. Heart and circulatory physiology 20091201
Title: The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20091201
Title: Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction.
Journal: Experimental cell research 20091115
Title: Plasma protein kinase C (PKC)alpha as a biomarker for the diagnosis of cancers.
Journal: Carcinogenesis 20091101
Title: Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini.
Journal: Pancreas 20091101
Title: Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes.
Journal: Neurochemical research 20091001
Title: PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function.
Journal: Biochimica et biophysica acta 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Neurotrophins induce neuregulin release through protein kinase Cdelta activation.
Journal: The Journal of biological chemistry 20090925
Title: Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis.
Journal: Biochemical and biophysical research communications 20090904
Title: Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways.
Journal: Journal of cellular biochemistry 20090801
Title: Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA.
Journal: Biochimica et biophysica acta 20090801
Title: Fluid phase endocytosis contributes to transfection of DNA by PEI-25.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20090801
Title: Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation.
Journal: Neuroscience bulletin 20090801
Title: Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways.
Journal: Experimental cell research 20090715
Title: Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.
Journal: Carcinogenesis 20090701
Title: Phosphorylation of myristoylated alanine-rich C kinase substrate is involved in the cAMP-dependent amylase release in parotid acinar cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20090601
Title: Rottlerin: a multifaced regulator of keratinocyte cell cycle.
Journal: Experimental dermatology 20090601
Title: Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells.
Journal: Carcinogenesis 20090501
Title: A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures.
Journal: Cell research 20090501
Title: Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells.
Journal: The Journal of nutrition 20090501
Title: Integrin signaling and cell spreading alterations by rottlerin treatment of chick limb bud mesenchymal cells.
Journal: Biochimie 20090501
Title: Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.
Journal: Cancer research 20090501
Title: Promiscuous aggregate-based inhibitors promote enzyme unfolding.
Journal: Journal of medicinal chemistry 20090409
Title: Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.
Journal: The American journal of pathology 20090401
Title: Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090201
Title: Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells.
Journal: PloS one 20090101
Title: Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
Journal: PloS one 20090101
Title: Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells.
Journal: Journal of biomedicine & biotechnology 20090101
Title: Role of protein kinase C-delta in isoproterenol-induced amylase release in rat parotid acinar cells.
Journal: The journal of medical investigation : JMI 20090101
Title: Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.
Journal: Biochemical and biophysical research communications 20081114
Title: Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-delta-independent pathway in human colon cancer cells.
Journal: Apoptosis : an international journal on programmed cell death 20081101
Title: Protein kinase C subtypes and retinal ischemic preconditioning.
Journal: Experimental eye research 20081001
Title: The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect.
Journal: Journal of cellular biochemistry 20080901
Title: Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages.
Journal: Journal of leukocyte biology 20080901
Title: Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.
Journal: Carcinogenesis 20080901
Title: Protection of human colon epithelial cells against deoxycholate by rottlerin.
Journal: Apoptosis : an international journal on programmed cell death 20080901
Title: Possible mechanism of rottlerin induced modulation of ischemia reperfusion injury in isolated rat hearts.
Journal: Biological & pharmaceutical bulletin 20080901
Title: Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway.
Journal: Diabetes 20080801
Title: Hypothalamic protein kinase C regulates glucose production.
Journal: Diabetes 20080801
Title: Chlorpromazine attenuates pancreatic beta-cell function and mass through IRS2 degradation, while exercise partially reverses the attenuation.
Journal: Journal of psychopharmacology (Oxford, England) 20080701
Title: Role of protein kinase Cdelta in paraquat-induced glial cell death.
Journal: Journal of neuroscience research 20080701
Title: G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes.
Journal: Cellular signalling 20080701
Title: Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis.
Journal: Autophagy 20080701
Title: Erbin-regulated sensitivity of MCF-7 breast cancer cells to TRAIL via ErbB2/AKT/NF-kappaB pathway.
Journal: Journal of biochemistry 20080601
Title: Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture.
Journal: Aging cell 20080601
Title: Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes.
Journal: Journal of cellular physiology 20080601
Title: House dust mite, Dermatophagoides pteronissinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells.
Journal: Cytokine 20080601
Title: PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction.
Journal: Biochemical and biophysical research communications 20080516
Title: Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase.
Journal: Experimental & molecular medicine 20080430
Title: Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.
Journal: Bioorganic & medicinal chemistry 20080415
Title: Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway.
Journal: Cancer research 20080415
Title: Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells.
Journal: Regulatory peptides 20080410
Title: Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells.
Journal: American journal of respiratory cell and molecular biology 20080401
Title: Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes.
Journal: Hepatology (Baltimore, Md.) 20080401
Title: Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells.
Journal: Life sciences 20080312
Title: Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells.
Journal: American journal of physiology. Cell physiology 20080301
Title: Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation.
Journal: American journal of physiology. Lung cellular and molecular physiology 20080301
Title: Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.
Journal: Hypertension (Dallas, Tex. : 1979) 20080301
Title: Small-molecule aggregates inhibit amyloid polymerization.
Journal: Nature chemical biology 20080301
Title: Aggregator compounds confound amyloid fibrillization assay.
Journal: Nature chemical biology 20080301
Title: STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816.
Journal: Journal of cellular biochemistry 20080215
Title: Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma.
Journal: Free radical biology & medicine 20080201
Title: Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.
Journal: Experimental and molecular pathology 20080201
Title: Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine.
Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20080201
Title: Differential effects of dialysis and ultrafiltrate from individuals with CKD, with or without diabetes, on platelet phosphatidylserine externalization.
Journal: American journal of physiology. Renal physiology 20080101
Title: [Production of chemoattractant-induced reactive oxygen species in human neutrophils--role of protein kinase C isoforms].
Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20080101
Title: The selectivity of protein kinase inhibitors: a further update.
Journal: The Biochemical journal 20071215
Title: Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells.
Journal: Biochimica et biophysica acta 20071201
Title: Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20071201
Title: Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes.
Journal: Neurobiology of disease 20071201
Title: Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta.
Journal: Basic & clinical pharmacology & toxicology 20071201
Title: Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells.
Journal: Journal of molecular and cellular cardiology 20071201
Title: Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein.
Journal: The American journal of pathology 20071201
Title: Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin.
Journal: Cellular signalling 20071101
Title: P2Y nucleotide receptor signaling through MAPK/ERK is regulated by extracellular matrix: involvement of beta3 integrins.
Journal: Journal of cellular physiology 20071001
Title: The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7.
Journal: Journal of biochemistry and molecular biology 20070930
Title: The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1.
Journal: Journal of ethnopharmacology 20070905
Title: Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase.
Journal: Brain research 20070905
Title: Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43.
Journal: American journal of physiology. Heart and circulatory physiology 20070901
Title: Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells.
Journal: American journal of physiology. Endocrinology and metabolism 20070901
Title: Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.
Journal: The Journal of pharmacology and experimental therapeutics 20070901
Title: Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta.
Journal: Trends in pharmacological sciences 20070901
Title: Protein kinase C delta is a critical regulator of CD1d-mediated antigen presentation.
Journal: European journal of immunology 20070901
Title: Expression of cyclin D3 through Sp1 sites by histone deacetylase inhibitors is mediated with protein kinase C-delta (PKC-delta) signal pathway.
Journal: Journal of cellular biochemistry 20070701
Title: Protein kinase C delta activated adhesion regulates vascular smooth muscle cell migration.
Journal: The Journal of surgical research 20070701
Title: Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors.
Journal: American journal of physiology. Cell physiology 20070701
Title: STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells.
Journal: Cell cycle (Georgetown, Tex.) 20070615
Title: Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070601
Title: Protein kinase C delta stimulates antigen presentation by Class II MHC in murine dendritic cells.
Journal: International immunology 20070601
Title: Curcumin-induced GADD153 upregulation: modulation by glutathione.
Journal: Journal of cellular biochemistry 20070515
Title: Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching.
Journal: Journal of cellular biochemistry 20070515
Title: Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
Journal: Oncogene 20070510
Title: Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells.
Journal: The Journal of biological chemistry 20070420
Title: Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070415
Title: TGF-beta-regulated collagen type I accumulation: role of Src-based signals.
Journal: American journal of physiology. Cell physiology 20070401
Title: Regulation of anion exchanger Slc26a6 by protein kinase C.
Journal: American journal of physiology. Cell physiology 20070401
Title: Role of PKCdelta in IFN-gamma-inducible CIITA gene expression.
Journal: Molecular immunology 20070401
Title: Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells.
Journal: Journal of cellular physiology 20070301
Title: Tissue transglutaminase inhibits autophagy in pancreatic cancer cells.
Journal: Molecular cancer research : MCR 20070301
Title: Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure.
Journal: The Journal of biological chemistry 20070216
Title: Rottlerin inhibits human T cell responses.
Journal: Biochemical pharmacology 20070215
Title: Targeting the hypoxia inducible factor pathway with mitochondrial uncouplers.
Journal: Molecular and cellular biochemistry 20070201
Title: Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role.
Journal: Journal of leukocyte biology 20070201
Title: Protein kinase C-mediated modulation of glutamate transporter activity in rat retina.
Journal: Current eye research 20070201
Title: Microarray-based kinase inhibition assay by gold nanoparticle probes.
Journal: Analytical chemistry 20070115
Title: Involvement of protein kinase Cdelta in iron chelator-induced IL-8 production in human intestinal epithelial cells.
Journal: Life sciences 20070109
Title: Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes.
Journal: Immunology and cell biology 20070101
Title: N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro.
Journal: The Journal of endocrinology 20070101
Title: Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C.
Journal: Immunology and cell biology 20070101
Title: PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells.
Journal: Autophagy 20070101
Title: Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophages.
Journal: Nitric oxide : biology and chemistry 20070101
Title: The epsilon-isoform of PKC mediates the hypertonic activation of cation channels in confluent monolayers of rat hepatocytes.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Title: PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation.
Journal: Blood 20061215
Title: Interpreting steep dose-response curves in early inhibitor discovery.
Journal: Journal of medicinal chemistry 20061214
Title: Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Journal: Journal of medicinal chemistry 20061214
Title: Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes.
Journal: Cancer letters 20061208
Title: [Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell].
Journal: Zhonghua yi xue za zhi 20061205
Title: Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells.
Journal: The Journal of pharmacology and experimental therapeutics 20061201
Title: Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.
Journal: The Journal of pharmacology and experimental therapeutics 20061101
Title: Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.
Journal: Nature cell biology 20061101
Title: STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20061001
Title: Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells.
Journal: Gastroenterology 20061001
Title: High-glucose-altered endothelial cell function involves both disruption of cell-to-cell connection and enhancement of force development.
Journal: The Journal of pharmacology and experimental therapeutics 20060801
Title: [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20060801
Title: Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress.
Journal: Free radical biology & medicine 20060615
Title: Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages.
Journal: Atherosclerosis 20060601
Title: Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium.
Journal: The Journal of investigative dermatology 20060601
Title: Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22.
Journal: Journal of leukocyte biology 20060601
Title: Multiple actions of lysophosphatidylcholine in human Jurkat T cells.
Journal: Acta pharmacologica Sinica 20060601
Title: Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling.
Journal: Cardiovascular research 20060501
Title: Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process.
Journal: Mechanisms of ageing and development 20060501
Title: Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060501
Title: Effect of protein kinase C inhibitors on porcine oocyte activation.
Journal: Journal of experimental zoology. Part A, Comparative experimental biology 20060401
Title: Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils.
Journal: Free radical research 20060401
Title: Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.
Journal: Biochemical and biophysical research communications 20060324
Title: Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines.
Journal: Mutation research 20060320
Title: 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta.
Journal: The Journal of biological chemistry 20060303
Title: Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL.
Journal: Leukemia 20060301
Title: Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2.
Journal: Apoptosis : an international journal on programmed cell death 20060301
Title: Contact inhibition causes strong downregulation of expression of MICA in human fibroblasts and decreased NK cell killing.
Journal: Human immunology 20060301
Title: Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.
Journal: Journal of cellular biochemistry 20060201
Title: Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways.
Journal: Pharmacological research 20060201
Title: Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms.
Journal: The international journal of biochemistry & cell biology 20060201
Title: Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages.
Journal: Journal of leukocyte biology 20060201
Title: BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes.
Journal: Journal of cellular physiology 20060101
Title: Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20060101
Title: Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism.
Journal: Biochimica et biophysica acta 20060101
Title: Regulation of CD93 cell surface expression by protein kinase C isoenzymes.
Journal: Microbiology and immunology 20060101
Title: Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle.
Journal: Lung 20060101
Title: Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis.
Journal: Arthritis research & therapy 20060101
Title: Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation.
Journal: The international journal of biochemistry & cell biology 20060101
Title: TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent.
Journal: Journal of endotoxin research 20060101
Title: Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells.
Journal: Journal of applied toxicology : JAT 20060101
Title: Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.
Journal: The Journal of biological chemistry 20051230
Title: NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.
Journal: The EMBO journal 20051221
Title: Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells.
Journal: Cancer letters 20051218
Title: Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
Journal: Cancer chemotherapy and pharmacology 20051201
Title: Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice.
Journal: American journal of physiology. Lung cellular and molecular physiology 20051201
Title: Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C.
Journal: Neurochemistry international 20051201
Title: Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells.
Journal: Immunology 20051201
Title: Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia.
Journal: Biochemical and biophysical research communications 20051111
Title: Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells.
Journal: FEBS letters 20051107
Title: PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis.
Journal: Journal of cellular biochemistry 20051015
Title: Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice.
Journal: The Journal of pharmacology and experimental therapeutics 20051001
Title: Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT.
Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20051001
Title: PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy.
Journal: The Biochemical journal 20050915
Title: Activation of the BK (SLO1) potassium channel by mallotoxin.
Journal: The Journal of biological chemistry 20050902
Title: Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.
Journal: Molecular biology of the cell 20050801
Title: Effect of protein kinase C activation on intracellular Ca2+ signaling and integrity of intestinal epithelial cells.
Journal: European journal of pharmacology 20050725
Title: Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.
Journal: Brain : a journal of neurology 20050701
Title: Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis.
Journal: The Journal of biological chemistry 20050701
Title: PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells.
Journal: Cardiovascular research 20050701
Title: The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade.
Journal: Life sciences 20050624
Title: Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.
Journal: The Journal of biological chemistry 20050501
Title: Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue.
Journal: The Journal of steroid biochemistry and molecular biology 20050501
Title: Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells.
Journal: Oncogene 20050428
Title: Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells.
Journal: Biochimica et biophysica acta 20050415
Title: Gefitinib ('Iressa', ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.
Journal: Cancer chemotherapy and pharmacology 20050401
Title: Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons.
Journal: Free radical biology & medicine 20050401
Title: Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.
Journal: The Journal of biological chemistry 20050304
Title: VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium.
Journal: American journal of physiology. Lung cellular and molecular physiology 20050201
Title: Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205.
Journal: Cellular signalling 20050201
Title: Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1.
Journal: Molecular biology of the cell 20050201
Title: Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050201
Title: Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1.
Journal: Diabetes 20050201
Title: Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line.
Journal: The FEBS journal 20050201
Title: Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP.
Journal: Oncogene 20050127
Title: Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model.
Journal: Journal of vascular research 20050101
Title: Mechanism of endothelin-1 activation of MAP kinases in neonatal pulmonary vascular smooth muscle.
Journal: Lung 20050101
Title: Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20041201
Title: Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20041201
Title: Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.
Journal: Annals of the New York Academy of Sciences 20041201
Title: Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction.
Journal: The Journal of pharmacology and experimental therapeutics 20041101
Title: IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes.
Journal: Microbes and infection 20041101
Title: Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20041101
Title: Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes.
Journal: Anesthesia and analgesia 20041101
Title: Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20041001
Title: Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.
Journal: The Journal of biological chemistry 20040924
Title: The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta.
Journal: Biochemical and biophysical research communications 20040903
Title: A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium.
Journal: Biochemical and biophysical research communications 20040827
Title: Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells.
Journal: Regulatory peptides 20040815
Title: Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes.
Journal: Cardiovascular research 20040815
Title: B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta.
Journal: The Journal of biological chemistry 20040716
Title: Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation.
Journal: Journal of molecular biology 20040716
Title: Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes.
Journal: Biochemical pharmacology 20040701
Title: Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation.
Journal: Molecules and cells 20040630
Title: PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth.
Journal: American journal of physiology. Heart and circulatory physiology 20040601
Title: Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle.
Journal: Shock (Augusta, Ga.) 20040601
Title: Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway.
Journal: The Journal of investigative dermatology 20040601
Title: Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK.
Journal: American journal of physiology. Heart and circulatory physiology 20040501
Title: Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway.
Journal: The Journal of biological chemistry 20040409
Title: Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex.
Journal: The Journal of biological chemistry 20040326
Title: Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins.
Journal: Circulation research 20040319
Title: Laminin 5 deposition regulates keratinocyte polarization and persistent migration.
Journal: Journal of cell science 20040315
Title: Down-regulation of Bcl-2 is associated with cisplatin resistance in human small cell lung cancer H69 cells.
Journal: Molecular cancer therapeutics 20040301
Title: Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
Journal: European journal of pharmacology 20040220
Title: IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta.
Journal: Cellular signalling 20040201
Title: Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells.
Journal: Journal of molecular endocrinology 20040201
Title: Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel.
Journal: The Journal of biological chemistry 20040130
Title: Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B.
Journal: The Journal of biological chemistry 20031219
Title: The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis.
Journal: The Journal of biological chemistry 20031212
Title: Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.
Journal: International immunology 20031201
Title: Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta.
Journal: Journal of enzyme inhibition and medicinal chemistry 20031201
Title: Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism.
Journal: International journal of molecular medicine 20031101
Title: A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion.
Journal: Biochemical pharmacology 20031015
Title: Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
Journal: The Journal of biological chemistry 20031003
Title: Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils.
Journal: Archives of biochemistry and biophysics 20030901
Title: Role of PKC-delta activity in glutathione-depleted neuroblastoma cells.
Journal: Free radical biology & medicine 20030901
Title: Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Journal: British journal of pharmacology 20030901
Title: Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.
Journal: Cancer research 20030815
Title: Asbestos-induced apoptosis is protein kinase C delta-dependent.
Journal: American journal of respiratory cell and molecular biology 20030801
Title: Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent.
Journal: Journal of neurochemistry 20030801
Title: Effect of detergent on 'promiscuous' inhibitors.
Journal: Journal of medicinal chemistry 20030731
Title: A generic time-resolved fluorescence assay for serine/threonine kinase activity: application to Cdc7/Dbf4.
Journal: Journal of biochemistry and molecular biology 20030731
Title: Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness.
Journal: The Journal of biological chemistry 20030718
Title: Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes.
Journal: The Biochemical journal 20030715
Title: Activation of protein kinase C delta by IFN-gamma.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030701
Title: Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart.
Journal: Journal of molecular and cellular cardiology 20030701
Title: Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor.
Journal: International archives of allergy and immunology 20030601
Title: Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis.
Journal: British journal of haematology 20030601
Title: Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
Journal: Journal of molecular endocrinology 20030601
Title: Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes.
Journal: Biochemical and biophysical research communications 20030523
Title: Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones.
Journal: Journal of neuroendocrinology 20030501
Title: Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function.
Journal: American journal of respiratory cell and molecular biology 20030501
Title: Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes.
Journal: Chemical research in toxicology 20030501
Title: Kinase inhibitors: not just for kinases anymore.
Journal: Journal of medicinal chemistry 20030410
Title: Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20030401
Title: The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20030401
Title: Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts.
Journal: Arthritis and rheumatism 20030301
Title: Protein kinase C delta is a prosurvival factor in human breast tumor cell lines.
Journal: Molecular cancer therapeutics 20030301
Title: Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.
Journal: The Journal of biological chemistry 20030227
Title: Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.
Journal: Cancer research 20030215
Title: Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells.
Journal: American journal of physiology. Cell physiology 20030201
Title: Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation.
Journal: The Journal of biological chemistry 20030131
Title: The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2.
Journal: The Journal of biological chemistry 20030103
Title: A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Journal: Neuroscience 20030101
Title: Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain.
Journal: Journal of vascular research 20030101
Title: Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration.
Journal: Neuroscience 20030101
Title: Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells.
Journal: Molecular endocrinology (Baltimore, Md.) 20021201
Title: Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.
Journal: The Journal of biological chemistry 20021122
Title: Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20021115
Title: Differential regulation of extrinsic and intrinsic cell death pathways by protein kinase C.
Journal: International journal of molecular medicine 20021101
Title: Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors.
Journal: Endocrine research 20021101
Title: Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells.
Journal: Free radical research 20021101
Title: Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells.
Journal: Experimental cell research 20021015
Title: Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation.
Journal: Endocrinology 20021001
Title: Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages.
Journal: The Journal of biological chemistry 20020927
Title: Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone.
Journal: Biology of reproduction 20020901
Title: Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity.
Journal: Hepatology (Baltimore, Md.) 20020901
Title: Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta.
Journal: The Biochemical journal 20020815
Title: Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway.
Journal: Experimental cell research 20020815
Title: Regulation of p53 stabilization by DNA damage and protein kinase C.
Journal: Molecular cancer therapeutics 20020801
Title: A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil.
Journal: American journal of physiology. Cell physiology 20020701
Title: Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway.
Journal: American journal of physiology. Heart and circulatory physiology 20020701
Title: Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.
Journal: Toxicology and applied pharmacology 20020701
Title: FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.
Journal: Biochemical and biophysical research communications 20020517
Title: Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells.
Journal: American journal of physiology. Lung cellular and molecular physiology 20020501
Title: Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells.
Journal: Journal of leukocyte biology 20020501
Title: Protein kinase Cdelta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest.
Journal: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20020501
Title: Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ.
Journal: Journal of neurochemistry 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C.
Journal: The Journal of biological chemistry 20020405
Title: Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion.
Journal: American journal of physiology. Renal physiology 20020401
Title: Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells.
Journal: The Journal of clinical investigation 20020315
Title: Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells.
Journal: The Journal of biological chemistry 20020308
Title: The role of protein kinase C-delta in PTH stimulation of IGF-binding protein-5 mRNA in UMR-106-01 cells.
Journal: American journal of physiology. Endocrinology and metabolism 20020301
Title: Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301
Title: Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38.
Journal: American journal of respiratory cell and molecular biology 20020201
Title: Effect of protein kinase C on endoplasmic reticulum cholesterol.
Journal: Biochemical and biophysical research communications 20020111
Title: PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats.
Journal: Basic research in cardiology 20020101
Title: Rottlerin stimulates metallothionein gene expression but inhibits metal transport in Chinese hamster ovary cells.
Journal: Toxicology and applied pharmacology 20011215
Title: Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20011214
Title: Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta.
Journal: Journal of cellular physiology 20011201
Title: Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes.
Journal: The Journal of pharmacology and experimental therapeutics 20011101
Title: Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts.
Journal: The Journal of clinical investigation 20011101
Title: Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.
Journal: Journal of molecular and cellular cardiology 20011101
Title: A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction.
Journal: Cancer letters 20011022
Title: Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation.
Journal: The Journal of biological chemistry 20011012
Title: Oxidant-dependent phosphorylation of p40phox in B lymphocytes.
Journal: Biochemical and biophysical research communications 20011005
Title: Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCdelta.
Journal: Molecular endocrinology (Baltimore, Md.) 20010901
Title: Involvement of protein kinase C-delta in DNA damage-induced apoptosis.
Journal: Cell death and differentiation 20010901
Title: Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblasts.
Journal: Oncogene 20010823
Title: Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells.
Journal: The Biochemical journal 20010815
Title: Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells.
Journal: Laboratory investigation; a journal of technical methods and pathology 20010801
Title: PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.
Journal: Biochemical and biophysical research communications 20010713
Title: NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha.
Journal: The Journal of biological chemistry 20010608
Title: Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta.
Journal: Endocrinology 20010601
Title: Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010501
Title: Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle.
Journal: Molecular endocrinology (Baltimore, Md.) 20010401
Title: Rottlerin induces a transformed phenotype in human keratinocytes.
Journal: Biochemical and biophysical research communications 20010330
Title: Essential activation of PKC-delta in opioid-initiated cardioprotection.
Journal: American journal of physiology. Heart and circulatory physiology 20010301
Title: The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells.
Journal: Biochemical and biophysical research communications 20010112
Title: Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed.
Journal: American journal of physiology. Lung cellular and molecular physiology 20010101
Title: Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells.
Journal: IUBMB life 20010101
Title: Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Journal: The Biochemical journal 20001001
Title: Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation.
Journal: Molecular endocrinology (Baltimore, Md.)
