83209-65-8,MFCD29924706
Catalog No.:AA00G2HX

83209-65-8 | HC TOXIN

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$236.00   $165.00
- +
5mg
≥95%
in stock  
$1,030.00   $721.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00G2HX
Chemical Name:
HC TOXIN
CAS Number:
83209-65-8
Molecular Formula:
C21H32N4O6
Molecular Weight:
436.5020
MDL Number:
MFCD29924706
SMILES:
O=C1N[C@H](C)C(=O)N[C@@H](C)C(=O)N2[C@@H](C(=O)N[C@H]1CCCCCC(=O)[C@@H]1CO1)CCC2
Properties
Computed Properties
 
Complexity:
741  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.1  

Literature

Title: Chemical phylogenetics of histone deacetylases.

Journal: Nature chemical biology 20100301

Title: Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro.

Journal: Cancer letters 20080608

Title: Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner.

Journal: International journal for parasitology 20080101

Title: HC-toxin.

Journal: Phytochemistry 20060701

Title: Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.

Journal: Journal of medicinal chemistry 20050505

Title: Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.

Journal: Cell cycle (Georgetown, Tex.) 20050501

Title: Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells.

Journal: Archives of pharmacal research 20040601

Title: Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells.

Journal: Archives of pharmacal research 20040501

Title: 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.

Journal: Journal of medicinal chemistry 20040226

Title: Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin.

Journal: Blood 20030301

Title: Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi.

Journal: Eukaryotic cell 20020801

Title: A gene related to yeast HOS2 histone deacetylase affects extracellular depolymerase expression and virulence in a plant pathogenic fungus.

Journal: The Plant cell 20010701

Title: 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.

Journal: Journal of medicinal chemistry 20010621

Title: Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.

Journal: Bioorganic & medicinal chemistry letters 20010122

Title: Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.

Journal: Carcinogenesis 20010101

Title: Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19961112

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Related Products of 83209-65-8
Tags:83209-65-8 Molecular Formula|83209-65-8 MDL|83209-65-8 SMILES|83209-65-8 HC TOXIN
Catalog No.: AA00G2HX
83209-65-8,MFCD29924706
83209-65-8 | HC TOXIN
Pack Size: 1mg
Purity: ≥95%
in stock
$236.00 $165.00
Pack Size: 5mg
Purity: ≥95%
in stock
$1,030.00 $721.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00G2HX
Chemical Name: HC TOXIN
CAS Number: 83209-65-8
Molecular Formula: C21H32N4O6
Molecular Weight: 436.5020
MDL Number: MFCD29924706
SMILES: O=C1N[C@H](C)C(=O)N[C@@H](C)C(=O)N2[C@@H](C(=O)N[C@H]1CCCCCC(=O)[C@@H]1CO1)CCC2
Properties
Complexity: 741  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 5  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.1  
Literature fold

Title: Chemical phylogenetics of histone deacetylases.

Journal: Nature chemical biology20100301

Title: Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro.

Journal: Cancer letters20080608

Title: Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner.

Journal: International journal for parasitology20080101

Title: HC-toxin.

Journal: Phytochemistry20060701

Title: Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.

Journal: Journal of medicinal chemistry20050505

Title: Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.

Journal: Cell cycle (Georgetown, Tex.)20050501

Title: Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells.

Journal: Archives of pharmacal research20040601

Title: Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells.

Journal: Archives of pharmacal research20040501

Title: 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.

Journal: Journal of medicinal chemistry20040226

Title: Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin.

Journal: Blood20030301

Title: Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi.

Journal: Eukaryotic cell20020801

Title: A gene related to yeast HOS2 histone deacetylase affects extracellular depolymerase expression and virulence in a plant pathogenic fungus.

Journal: The Plant cell20010701

Title: 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.

Journal: Journal of medicinal chemistry20010621

Title: Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.

Journal: Bioorganic & medicinal chemistry letters20010122

Title: Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.

Journal: Carcinogenesis20010101

Title: Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

Journal: Proceedings of the National Academy of Sciences of the United States of America19961112

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