[1]CurrentPatentAssignee:ADDEXTHERAPEUTICSSA-WO2005/44797,2005,A1Locationinpatent:Page/Pagecolumn61
Title: In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat.
Journal: Neuropharmacology 20130101
Title: mGlu5 Receptor Functional Interactions and Addiction.
Journal: Frontiers in pharmacology 20120101
Title: On the Role of Cannabinoid CB1- and μ-Opioid Receptors in Motor Impulsivity.
Journal: Frontiers in pharmacology 20120101
Title: Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP.
Journal: Neuropharmacology 20110901
Title: Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.
Journal: Bioorganic & medicinal chemistry letters 20110501
Title: Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.
Journal: Frontiers in pharmacology 20110101
Title: Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.
Journal: Dialogues in clinical neuroscience 20100901
Title: Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator.
Journal: European journal of pharmacology 20100810
Title: Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia.
Journal: Pharmacology, biochemistry, and behavior 20100301
Title: Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.
Journal: The open medicinal chemistry journal 20100101
Title: Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor.
Journal: Molecular pharmacology 20091201
Title: Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity.
Journal: European journal of pharmacology 20091125
Title: Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273.
Journal: ChemMedChem 20090401
Title: ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities.
Journal: The Journal of pharmacology and experimental therapeutics 20081201
Title: Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.
Journal: Journal of medicinal chemistry 20060601
Title: Liu F, et al. ADX47273 [S-(4-fluoro-phenyl)-{3--(4-fluoro-phenyl)-,2,4-oxadiazol-5-yl-piperidin-1-yl}-methanone: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008 Dec;327(3):827-39.
Title: Schlumberger C, et, al. Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia. Pharmacol Biochem Behav. 2010 Mar;95(1):23-30.
Title: Xu J, et al. Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning. Learn Mem. 2013 Jul 18;20(8):438-45.
