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780757-88-2,MFCD12196918
Catalog No.:AA00G3FP

780757-88-2 | Icg-001

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$25.00   $18.00
- +
5mg
99%
in stock  
$63.00   $44.00
- +
10mg
99%
in stock  
$94.00   $66.00
- +
100mg
98%
in stock  
$537.00   $376.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G3FP
Chemical Name:
Icg-001
CAS Number:
780757-88-2
Molecular Formula:
C33H32N4O4
Molecular Weight:
548.6316
MDL Number:
MFCD12196918
SMILES:
Oc1ccc(cc1)CC1C(=O)N(CC2N1C(=O)CCN2C(=O)NCc1ccccc1)Cc1cccc2c1cccc2
Properties
Computed Properties
 
Complexity:
930  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
4.1  

Downstream Synthesis Route

[1]Piergentili,Alessandro;DelBello,Fabio;Gentili,Francesco;Giannella,Mario;Quaglia,Wilma;Vesprini,Cristian;Thomas,RussellJ.;Robertson,GraemeM.[Tetrahedron,2007,vol.63,#52,p.12912-12916]

[2]CurrentPatentAssignee:TOTTORIUNIVERSITY;TOKYOWOMEN'SMEDICALUNIVERSITY;KANONCURE-EP2698365,2014,A1Locationinpatent:Paragraph0098-0099

[1]CurrentPatentAssignee:TOTTORIUNIVERSITY;TOKYOWOMEN'SMEDICALUNIVERSITY;KANONCURE-EP2698365,2014,A1

[1]CurrentPatentAssignee:TOTTORIUNIVERSITY;TOKYOWOMEN'SMEDICALUNIVERSITY;KANONCURE-EP2698365,2014,A1

[1]CurrentPatentAssignee:TOTTORIUNIVERSITY;TOKYOWOMEN'SMEDICALUNIVERSITY;KANONCURE-EP2698365,2014,A1

[1]CurrentPatentAssignee:TOTTORIUNIVERSITY;TOKYOWOMEN'SMEDICALUNIVERSITY;KANONCURE-EP2698365,2014,A1

Literature

Title: Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy.

Journal: Chemico-biological interactions 20170801

Title: Altering cancer transcriptomes using epigenomic inhibitors.

Journal: Epigenetics & chromatin 20150101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20130115

Title: Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model.

Journal: PloS one 20120101

Title: The gamma catenin/CBP complex maintains survivin transcription in β-catenin deficient/depleted cancer cells.

Journal: Current cancer drug targets 20110201

Title: High-throughput screening compatible cell-based assay for interrogating activated notch signaling.

Journal: Assay and drug development technologies 20090201

Title: Yan D, et al, Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J Biol Chem, 2012, 287(11), 8598-8612.

Title: Henderson WR Jr, et al, Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA, 2010, 107(32), 14309-14314.

Title: Emami KH, et al. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected Proc Natl Acad Sci USA, 2004, 101(34), 12682-12687.

Title: Liu Y, et al. ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population. J Exp Clin Cancer Res. 2017 Sep 11;36(1):125.

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