Home Other Building Blocks 857890-39-2
857890-39-2,MFCD18633219
Catalog No.:AA00G3IQ

857890-39-2 | Lenvatinib mesylate

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50mg
99%
in stock  
$8.00   $6.00
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100mg
99%
in stock  
$11.00   $8.00
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250mg
99%
in stock  
$17.00   $12.00
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1g
99%
in stock  
$45.00   $32.00
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5g
99%
in stock  
$128.00   $89.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G3IQ
Chemical Name:
Lenvatinib mesylate
CAS Number:
857890-39-2
Molecular Formula:
C22H23ClN4O7S
Molecular Weight:
522.9586
MDL Number:
MFCD18633219
SMILES:
CS(=O)(=O)O.COc1cc2nccc(c2cc1C(=O)N)Oc1ccc(c(c1)Cl)NC(=O)NC1CC1
Properties
Computed Properties
 
Complexity:
727  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  

Literature

Title: Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial.

Journal: Lancet (London, England) 20180324

Title: Lenvatinib: first global approval.

Journal: Drugs 20150401

Title: A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours.

Journal: British journal of cancer 20120508

Title: Novel molecular targeted therapies for refractory thyroid cancer.

Journal: Head & neck 20120501

Title: Unique metabolic pathway of [(14)C]lenvatinib after oral administration to male cynomolgus monkey.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401

Title: Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301

Title: Antitumour activity of oral E7080, a novel inhibitor of multiple tyrosine kinases, in human sarcoma xenografts.

Journal: International journal of cancer 20110801

Title: E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor.

Journal: Molecular cancer therapeutics 20110701

Title: Phase I dose-escalation study and biomarker analysis of E7080 in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110415

Title: Antiangiogenic therapies for malignant pleural mesothelioma.

Journal: Frontiers in bioscience (Landmark edition) 20110101

Title: E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion.

Journal: BMC cancer 20110101

Title: A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080.

Journal: Journal of pharmacokinetics and pharmacodynamics 20100801

Title: E7080, a multi-tyrosine kinase inhibitor, suppresses the progression of malignant pleural mesothelioma with different proangiogenic cytokine production profiles.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20091201

Title: Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080901

Title: E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition.

Journal: International journal of cancer 20080201

Title: Kudo M, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellularcarcinoma: a randomised phase 3 non-inferiority trial. Lancet. 2018 Mar 24;391(10126):1163-1173.

Title: Suyama K, et al. Lenvatinib: A Promising Molecular Targeted Agent for Multiple Cancers. Cancer Control. 2018 Jan-Dec;25(1):1073274818789361.

Title: 3.Matsui J, et al. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res. 2008, 14(17),545.

Title: Matsui J, et al. E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer. 2008, 122(3), 664-671.

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SDS
Tags:857890-39-2 Molecular Formula|857890-39-2 MDL|857890-39-2 SMILES|857890-39-2 Lenvatinib mesylate