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832714-46-2,MFCD12032117
Catalog No.:AA00G3KP

832714-46-2 | Isopropyl 4-{[1-(2-fluoro-4-methanesulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy}piperidine-1-carboxylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$63.00   $44.00
- +
5mg
≥95%
in stock  
$289.00   $202.00
- +
25mg
95%
in stock  
$365.00   $255.00
- +
100mg
95%
in stock  
$836.00   $585.00
- +
500mg
95%
in stock  
$2,800.00   $1,960.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00G3KP
Chemical Name:
Isopropyl 4-{[1-(2-fluoro-4-methanesulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy}piperidine-1-carboxylate
CAS Number:
832714-46-2
Molecular Formula:
C21H24FN5O5S
Molecular Weight:
477.5092
MDL Number:
MFCD12032117
SMILES:
CC(OC(=O)N1CCC(CC1)Oc1ncnc2c1cnn2c1ccc(cc1F)S(=O)(=O)C)C
Properties
Computed Properties
 
Complexity:
788  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.7  

Literature

Title: Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.

Journal: Bioorganic & medicinal chemistry letters 20120215

Title: Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: Semple G, et al. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21(10):3134-41.

Title: Bahirat UA, et, al. APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice. Eur J Pharmacol. 2017 Apr 15;801:35-45.

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Tags:832714-46-2 Molecular Formula|832714-46-2 MDL|832714-46-2 SMILES|832714-46-2 Isopropyl 4-{[1-(2-fluoro-4-methanesulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy}piperidine-1-carboxylate
Catalog No.: AA00G3KP
832714-46-2,MFCD12032117
832714-46-2 | Isopropyl 4-{[1-(2-fluoro-4-methanesulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy}piperidine-1-carboxylate
Pack Size： 1mg
Purity： ≥95%
in stock
$63.00 $44.00
Pack Size： 5mg
Purity： ≥95%
in stock
$289.00 $202.00
Pack Size： 25mg
Purity： 95%
in stock
$365.00 $255.00
Pack Size： 100mg
Purity： 95%
in stock
$836.00 $585.00
Pack Size： 500mg
Purity： 95%
in stock
$2,800.00 $1,960.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00G3KP
Chemical Name: Isopropyl 4-{[1-(2-fluoro-4-methanesulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy}piperidine-1-carboxylate
CAS Number: 832714-46-2
Molecular Formula: C21H24FN5O5S
Molecular Weight: 477.5092
MDL Number: MFCD12032117
SMILES: CC(OC(=O)N1CCC(CC1)Oc1ncnc2c1cnn2c1ccc(cc1F)S(=O)(=O)C)C
Properties
Complexity: 788  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 33  
Hydrogen Bond Acceptor Count: 9  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.7  
Literature fold

Title: Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.

Journal: Bioorganic & medicinal chemistry letters20120215

Title: Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.

Journal: Bioorganic & medicinal chemistry letters20110515

Title: Semple G, et al. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21(10):3134-41.

Title: Bahirat UA, et, al. APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice. Eur J Pharmacol. 2017 Apr 15;801:35-45.

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