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83280-65-3,MFCD28155270
Catalog No.:AA00G3KU

83280-65-3 | 2-Acetylfuro-1,4-naphthoquinone

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1mg
98%
in stock  
$22.00   $15.00
- +
5mg
98%
in stock  
$35.00   $25.00
- +
10mg
98%
in stock  
$45.00   $32.00
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250mg
98%
in stock  
$183.00   $128.00
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1g
98%
in stock  
$456.00   $320.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G3KU
Chemical Name:
2-Acetylfuro-1,4-naphthoquinone
CAS Number:
83280-65-3
Molecular Formula:
C14H8O4
Molecular Weight:
240.2109
MDL Number:
MFCD28155270
SMILES:
CC(=O)c1cc2c(o1)C(=O)c1c(C2=O)cccc1
Properties
Computed Properties
 
Complexity:
414  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
1  
XLogP3:
2.3  

Downstream Synthesis Route

[1]SyntheticCommunications,1989,vol.19,p.1061-1070

[1]MagneticResonanceinChemistry,1989,vol.27,p.1176-1177

[1]JournalofHeterocyclicChemistry,1984,vol.21,p.621-622

[1]Patent:CN109988157,2019,A.Locationinpatent:Paragraph0015;0021-0022

[2]MedChemComm,2019,vol.10,p.1635-1640

[3]JournalofHeterocyclicChemistry,1984,vol.21,p.621-622

[4]Tetrahedron,2000,vol.56,p.8845-8853

[5]SyntheticCommunications,2001,vol.31,p.381-386

[6]Patent:WO2012/119265,2012,A1.Locationinpatent:Page/Pagecolumn61

[7]Patent:US2013/345176,2013,A1.Locationinpatent:Paragraph0151

[8]Patent:WO2017/79864,2017,A1.Locationinpatent:Paragraph00148;00149;00150

[9]JournaloftheChemicalSociety.PerkinTransactions1(2001),2001,p.2946-2957

[10]EuropeanJournalofMedicinalChemistry,2018,vol.151,p.39-50

[11]Patent:CN107973788,2018,A.Locationinpatent:Paragraph0110;0111;0112

[12]SyntheticCommunications,1989,vol.19,p.1061-1070

[13]MagneticResonanceinChemistry,1989,vol.27,p.1176-1177

[14]Patent:WO2013/166618,2013,A1.Locationinpatent:Page/Pagecolumn16-17

[1]Phytochemistry,1991,vol.30,p.2379-2381

[2]ChemicalandPharmaceuticalBulletin,2013,vol.61,p.670-673

[3]Patent:US2019/62294,2019,A1.Locationinpatent:Paragraph0390;0394

Literature

Title: Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin.

Journal: Cancer medicine 20160601

Title: Suppression of cancer relapse and metastasis by inhibiting cancer stemness.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20150210

Title: Synthesis and structure-activity relationships of lapacho analogues. 1. Suppression of human keratinocyte hyperproliferation by 2-substituted naphtho[2,3-b]furan-4,9-diones, activation by enzymatic one- and two-electron reduction, and intracellular generation of superoxide.

Journal: Journal of medicinal chemistry 20120823

Title: Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants.

Journal: Parasitology research 20120401

Title: Antiprotozoal activities of some constituents of Markhamia tomentosa (Bignoniaceae).

Journal: Annals of tropical medicine and parasitology 20100701

Title: Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol.

Journal: Bioorganic & medicinal chemistry letters 20081015

Title: Zhang Y, et al. Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin. Cancer Med. 2016 Jun;5(6):1251-8.

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