Title: Topical therapies for periorbital cutaneous malignancies: indications and treatment regimens.
Journal: Current opinion in ophthalmology20120901
Title: Ingenol mebutate gel for actinic keratosis.
Journal: The New England journal of medicine20120315
Title: Ivacaftor, vismodegib, and ingenol mebutate.
Journal: Journal of the American Pharmacists Association : JAPhA20120101
Title: What's new in the treatment of actinic keratoses?
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Title: Topical antineoplastic agents in the treatment of mucocutaneous diseases.
Journal: Current problems in dermatology20110101
Title: Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta.
Journal: The Journal of biological chemistry20100730
Title: The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.
Journal: Cancer research20100601
Title: Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
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Title: Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells.
Journal: Cancer research20090515
Title: PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study.
Journal: The Australasian journal of dermatology20090201
Title: Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells.
Journal: British journal of cancer20081202
Title: Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate.
Journal: Journal of immunology (Baltimore, Md. : 1950)20061201
Title: Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway.
Journal: Cancer research20061015
Title: HIV type 1 inhibition by protein kinase C modulatory compounds.
Journal: AIDS research and human retroviruses20060901
Title: PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.
Journal: Blood20050815
Title: Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells.
Journal: Molecular cancer therapeutics20041201
Title: Characterization of the interaction of ingenol 3-angelate with protein kinase C.
Journal: Cancer research20040501
Title: Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death.
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