Title: Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20140201
Title: CGRP receptor antagonism and migraine therapy.
Journal: Current protein & peptide science 20130801
Title: Management of acute and chronic migraine.
Journal: Current opinion in supportive and palliative care 20120601
Title: CGRP receptor antagonists: an expanding drug class for acute migraine?
Journal: Expert opinion on investigational drugs 20120601
Title: [Therapy and prophylaxis of migraine].
Journal: MMW Fortschritte der Medizin 20120419
Title: A randomized, placebo-controlled study of the effects of telcagepant on exercise time in patients with stable angina.
Journal: Clinical pharmacology and therapeutics 20120301
Title: Randomized, controlled study of telcagepant in patients with migraine and coronary artery disease.
Journal: Headache 20120201
Title: High-throughput polymer monolith in-tip SPME fiber preparation and application in drug analysis.
Journal: Bioanalysis 20111201
Title: ACS chemical neuroscience molecule spotlight on Telcagepant (MK-0974).
Journal: ACS chemical neuroscience 20110720
Title: Optimal balance of efficacy and tolerability of oral triptans and telcagepant: a review and a clinical comment.
Journal: The journal of headache and pain 20110601
Title: Treatment of migraine: update on new therapies.
Journal: Current opinion in neurology 20110601
Title: Effect of telcagepant on spontaneous ischemia in cardiovascular patients in a randomized study.
Journal: Headache 20110601
Title: EuroQol (EQ-5D) health utility scores for patients with migraine.
Journal: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20110501
Title: Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.
Journal: Bioorganic & medicinal chemistry letters 20110501
Title: The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men.
Journal: British journal of clinical pharmacology 20110501
Title: Possible site of action of CGRP antagonists in migraine.
Journal: Cephalalgia : an international journal of headache 20110401
Title: Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine.
Journal: Headache 20110401
Title: Pain freedom at 2 hours in migraine after telcagepant 300 mg.
Journal: CNS drugs 20110301
Title: Current understanding and treatment of headache disorders: five new things.
Journal: Neurology 20110215
Title: Sustained pain freedom and no adverse events as an endpoint in clinical trials of acute migraine treatments: application to patient-level data from a trial of the CGRP receptor antagonist, telcagepant, and zolmitriptan.
Journal: Cephalalgia : an international journal of headache 20110201
Title: Antimigraine efficacy of telcagepant based on patient's historical triptan response.
Journal: Headache 20110101
Title: Excellent tolerability but relatively low initial clinical efficacy of telcagepant in migraine.
Journal: Headache 20110101
Title: Long-term tolerability of telcagepant for acute treatment of migraine in a randomized trial.
Journal: Headache 20110101
Title: Single- and multiple-dose pharmacokinetics and tolerability of telcagepant, an oral calcitonin gene-related peptide receptor antagonist, in adults.
Journal: Journal of clinical pharmacology 20101201
Title: Randomized, controlled trial of telcagepant over four migraine attacks.
Journal: Cephalalgia : an international journal of headache 20101201
Title: [Calcitonin gene-related peptide and migraine. Increases understanding of physiopathology can lead to new drug therapy].
Journal: Lakartidningen 20101201
Title: Effect of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant in human cranial arteries.
Journal: Cephalalgia : an international journal of headache 20101001
Title: Asymmetric hydrogenation of protected allylic amines.
Journal: Organic letters 20100917
Title: Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.
Journal: Structure (London, England : 1993) 20100908
Title: Characterization of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) in human isolated coronary arteries.
Journal: The Journal of pharmacology and experimental therapeutics 20100901
Title: New drugs in migraine treatment and prophylaxis: telcagepant and topiramate.
Journal: Lancet (London, England) 20100821
Title: Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.
Journal: CNS drugs 20100701
Title: Calcitonin gene-related peptide receptor antagonists for migraine.
Journal: Expert opinion on investigational drugs 20100701
Title: Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries.
Journal: Journal of cardiovascular pharmacology 20100501
Title: CGRP receptor antagonism and migraine.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20100401
Title: Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding.
Journal: Biochemical and biophysical research communications 20100326
Title: Randomized, controlled trial of telcagepant for the acute treatment of migraine.
Journal: Neurology 20100323
Title: Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.
Journal: Biochemical and biophysical research communications 20100101
Title: Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).
Journal: British journal of clinical pharmacology 20100101
Title: Is there an inherent limit to the efficacy of calcitonin gene-related peptide receptor antagonists in the acute treatment of migraine? A comment.
Journal: The journal of headache and pain 20091201
Title: New drugs for migraine.
Journal: The journal of headache and pain 20091201
Title: The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs.
Journal: Pharmacology & therapeutics 20091201
Title: Is there an inherent limit to acute migraine treatment efficacy?
Journal: The journal of headache and pain 20091201
Title: Calcitonin gene-related peptide receptor antagonists for the treatment of migraine: a patent review.
Journal: Expert opinion on therapeutic patents 20091201
Title: CGRP antagonists: hope for a new era in acute migraine treatment.
Journal: Acta neurologica Belgica 20091201
Title: Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.
Journal: Bioorganic & medicinal chemistry letters 20091115
Title: Randomized, controlled trial of telcagepant for the acute treatment of migraine.
Journal: Neurology 20090922
Title: [Migraine can signal a risk for heart and brain].
Journal: MMW Fortschritte der Medizin 20090910
Title: The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20090815
Title: Telcagepant, a calcitonin gene-related peptide antagonist for the treatment of migraine.
Journal: Current opinion in investigational drugs (London, England : 2000) 20090701
Title: Elimination of diastereomer interference to determine Telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography/tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090601
Title: A flexible and high throughput liquid chromatography-tandem mass spectrometric assay for the quantitation of telcagepant in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090515
Title: [CGRP antagonists: novel concept for treatment of migraine].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20090501
Title: Migraine: Telcagepant provides new hope for people with migraine.
Journal: Nature reviews. Neurology 20090501
Title: [Gepants: the beginning of a new age in the symptomatic treatment of migraine?].
Journal: Revista de neurologia 20090401
Title: An oral calcitonin gene-related peptide receptor antagonist for acute migraine management: sign of a possible new chapter in headache medicine.
Journal: Current neurology and neuroscience reports 20090301
Title: Molecule of the month. Telcagepant.
Journal: Drug news & perspectives 20090301
Title: CGRP receptors in the control of pain and inflammation.
Journal: Current opinion in pharmacology 20090201
Title: Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine.
Journal: European journal of pharmacology 20090114
Title: Preclinical pharmacokinetics of MK-0974, an orally active calcitonin-gene related peptide (CGRP)-receptor antagonist, mechanism of dose dependency and species differences.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090101
Title: Calcitonin gene-related peptide receptor antagonists for the treatment of migraine.
Journal: Progress in medicinal chemistry 20090101
Title: Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial.
Journal: Lancet (London, England) 20081220
Title: CGRP-receptor antagonism in migraine treatment.
Journal: Lancet (London, England) 20081220
Title: Reversed-phase chiral liquid chromatography on polysaccharide-based stationary phase coupled with tandem mass spectrometry for simultaneous determination of four stereoisomers of MK-0974 in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081001
Title: Clinical and preclinical rationale for CGRP-receptor antagonists in the treatment of migraine.
Journal: Headache 20080901
Title: Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache.
Journal: Organic letters 20080807
Title: Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine.
Journal: Neurology 20080415
Title: [A new therapeutic principle for migraine].
Journal: Ugeskrift for laeger 20080317
Title: Strategies on efficient method development of on-line extraction assays for determination of MK-0974 in human plasma and urine using turbulent-flow chromatography and tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080215
Title: Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine.
Journal: The Journal of pharmacology and experimental therapeutics 20080201
Title: Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system.
Journal: The journal of headache and pain 20080201
Title: The tortuous road to an ideal CGRP function blocker for the treatment of migraine.
Journal: Current topics in medicinal chemistry 20080101
Title: Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).
Journal: Journal of medicinal chemistry 20071115
Title: CGRP antagonists: unravelling the role of CGRP in migraine.
Journal: Trends in pharmacological sciences 20071101
Title: Salvatore CA, et al. Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl-4-(2-oxo-2,3-dihydro-1H-imidazo,5-bpyridin-1-yl)piperidine-1-carboxamide, a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine. J Pharmacol Exp Ther. 2008 Feb;324(2):416-21. Epub 2007 Nov 26.
Title: Moore EL, et al. Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine. Eur J Pharmacol. 2009 Jan 14;602(2-3):250-4.
Title: Roller S, et al. Preclinical pharmacokinetics of MK-0974, an orally active calcitonin-gene related peptide (CGRP)-receptor antagonist, mechanism of dose dependency and species differences. Xenobiotica. 2009 Jan;39(1):33-45.