Home Other Building Blocks 783355-60-2
783355-60-2,MFCD10565969
Catalog No.:AA00G3MO

783355-60-2 | Pci-24781

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
5mg
98%
in stock  
$29.00   $21.00
- +
10mg
98%
in stock  
$44.00   $31.00
- +
25mg
98%
in stock  
$73.00   $51.00
- +
50mg
98%
in stock  
$114.00   $80.00
- +
250mg
98%
in stock  
$320.00   $224.00
- +
1g
98%
in stock  
$823.00   $576.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G3MO
Chemical Name:
Pci-24781
CAS Number:
783355-60-2
Molecular Formula:
C21H23N3O5
Molecular Weight:
397.4244
MDL Number:
MFCD10565969
SMILES:
ONC(=O)c1ccc(cc1)OCCNC(=O)c1oc2c(c1CN(C)C)cccc2
Properties
Computed Properties
 
Complexity:
550  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
2.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:SHANGHAIUNIVERSITYOFENGINEERINGSCIENCES-CN113527237,2021,ALocationinpatent:Paragraph0048;0068;0070-0073;0075

[2]CurrentPatentAssignee:ABBVIEINC-WO2004/92115,2004,A2Locationinpatent:Page76

[3]CurrentPatentAssignee:ABBVIEINC-WO2004/92115,2004,A2Locationinpatent:Page82-83

[1]CurrentPatentAssignee:ABBVIEINC-WO2004/92115,2004,A2Locationinpatent:Page83

[2]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2022/261401,2022,A1Locationinpatent:Paragraph00193

[1]CurrentPatentAssignee:ABBVIEINC;SERVIERMONDE-US2014/249215,2014,A1Locationinpatent:Paragraph0031

[1]CurrentPatentAssignee:SERVIERMONDE-WO2016/36910,2016,A1Locationinpatent:Page/Pagecolumn19

[1]CurrentPatentAssignee:SERVIERMONDE-WO2016/36910,2016,A1Locationinpatent:Page/Pagecolumn19

Literature

Title: The therapeutic effect of histone deacetylase inhibitor PCI-24781 on gallbladder carcinoma in BK5.erbB2 mice.

Journal: Journal of hepatology 20120701

Title: Vorinostat in acute myeloid leukemia and myelodysplastic syndromes.

Journal: Expert opinion on investigational drugs 20110201

Title: Deactylase inhibition in myeloproliferative neoplasms.

Journal: Investigational new drugs 20101201

Title: A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells.

Journal: Biochemical and biophysical research communications 20100205

Title: PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090515

Title: CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.

Journal: Molecular cancer therapeutics 20060501

Title: Buggy JJ, et al. CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. Mol Cancer Ther, 2006, 5(5), 1309-1317.

Title: Adimoolam S, et al. HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination. Proc Natl Acad Sci U S A, 2007, 104(49), 19482-19487.

Title: Lopez G, et al. Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma. Clin Cancer Res, 2009, 15(10), 3472-3483.

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SDS
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