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Home Other Building Blocks 784210-88-4
784210-88-4,MFCD18633230
Catalog No.:AA00G3N2

784210-88-4 | RGB-286638 free base

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
≥98%
in stock  
$123.00   $86.00
- +
250mg
≥98%
in stock  
$270.00   $189.00
- +
500mg
≥98%
in stock  
$480.00   $336.00
- +
  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00G3N2
Chemical Name:
RGB-286638 free base
CAS Number:
784210-88-4
Molecular Formula:
C29H35N7O4
Molecular Weight:
545.6327
MDL Number:
MFCD18633230
SMILES:
COCCN1CCN(CC1)Cc1ccc(cc1)c1n[nH]c2c1C(=O)c1c2cccc1NC(=O)NN1CCOCC1
Properties
Computed Properties
 
Complexity:
857  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
2  

Literature

Title: Phase I study of RGB-286638, a novel, multitargeted cyclin-dependent kinase inhibitor in patients with solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20140915

Title: Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs.

Journal: Leukemia 20131201

Title: Validated bioanalytical method for the quantification of RGB-286638, a novel multi-targeted protein kinase inhibitor, in human plasma and urine by liquid chromatography/tandem triple-quadrupole mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20091205

Title: Cirstea D, et al. Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75.

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Tags:784210-88-4 Molecular Formula|784210-88-4 MDL|784210-88-4 SMILES|784210-88-4 RGB-286638 free base