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857066-90-1,MFCD09039129
Catalog No.:AA00G3NG

857066-90-1 | Tmc353121

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$375.00   $263.00
- +
10mg
≥98%
in stock  
$650.00   $455.00
- +
50mg
≥98%
in stock  
$1,859.00   $1,302.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00G3NG
Chemical Name:
Tmc353121
CAS Number:
857066-90-1
Molecular Formula:
C32H42N6O3
Molecular Weight:
558.7143
MDL Number:
MFCD09039129
SMILES:
OCCCc1ccc(cc1NCc1ccc2c(c1)n(Cc1nc(C)ccc1O)c(n2)NCCCN1CCOCC1)C
Properties
Computed Properties
 
Complexity:
757  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
13  
XLogP3:
4.2  

Literature

Title: Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model.

Journal: The European respiratory journal 20110801

Title: Respiratory syncytial virus therapy and prophylaxis: have we finally turned the corner?

Journal: The European respiratory journal 20110801

Title: Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection.

Journal: Current opinion in drug discovery & development 20090701

Title: Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121).

Journal: Journal of medicinal chemistry 20080227

Title: Bonfanti JF, et al. Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121). J Med Chem. 2008 Feb 28;51(4):875-96.

Title: Rouan MC, et al. Pharmacokinetics-pharmacodynamics of a respiratory syncytial virus fusion inhibitor in the cotton rat model. Antimicrob Agents Chemother. 2010 Nov;54(11):4534-9.

Title: Olszewska W, et al. Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model. Eur Respir J. 2011 Aug;38(2):401-8.

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SDS
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Tags:857066-90-1 Molecular Formula|857066-90-1 MDL|857066-90-1 SMILES|857066-90-1 Tmc353121
Catalog No.: AA00G3NG
857066-90-1,MFCD09039129
857066-90-1 | Tmc353121
Pack Size： 5mg
Purity： ≥98%
in stock
$375.00 $263.00
Pack Size： 10mg
Purity： ≥98%
in stock
$650.00 $455.00
Pack Size： 50mg
Purity： ≥98%
in stock
$1,859.00 $1,302.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00G3NG
Chemical Name: Tmc353121
CAS Number: 857066-90-1
Molecular Formula: C32H42N6O3
Molecular Weight: 558.7143
MDL Number: MFCD09039129
SMILES: OCCCc1ccc(cc1NCc1ccc2c(c1)n(Cc1nc(C)ccc1O)c(n2)NCCCN1CCOCC1)C
Properties
Complexity: 757  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 41  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 4  
Rotatable Bond Count: 13  
XLogP3: 4.2  
Literature fold

Title: Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model.

Journal: The European respiratory journal20110801

Title: Respiratory syncytial virus therapy and prophylaxis: have we finally turned the corner?

Journal: The European respiratory journal20110801

Title: Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection.

Journal: Current opinion in drug discovery & development20090701

Title: Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121).

Journal: Journal of medicinal chemistry20080227

Title: Bonfanti JF, et al. Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121). J Med Chem. 2008 Feb 28;51(4):875-96.

Title: Rouan MC, et al. Pharmacokinetics-pharmacodynamics of a respiratory syncytial virus fusion inhibitor in the cotton rat model. Antimicrob Agents Chemother. 2010 Nov;54(11):4534-9.

Title: Olszewska W, et al. Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model. Eur Respir J. 2011 Aug;38(2):401-8.

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