Title: CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study.
Journal: Current Alzheimer research 20130901
Title: Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie.
Journal: Prion 20120101
Title: Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
Journal: Bioorganic & medicinal chemistry letters 20111215
Title: The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.
Journal: Journal of molecular neuroscience : MN 20110901
Title: Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates.
Journal: Journal of medicinal chemistry 20110414
Title: The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.
Journal: Journal of Alzheimer's disease : JAD 20110101
Title: CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease.
Journal: Journal of Alzheimer's disease : JAD 20100101
Title: Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives.
Journal: Journal of Alzheimer's disease : JAD 20100101
Title: CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.
Journal: British journal of pharmacology 20090301
Title: 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
Journal: The Journal of pharmacology and experimental therapeutics 20071201
Title: In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.
Journal: Pharmacological research 20070401
Title: Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
Journal: Journal of medicinal chemistry 20050908
Title: Imbimbo BP, et al. 1-(3',4'-Dichloro-2-fluoro,1'-biphenyl-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretasemodulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease withoutcausing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-830.
Title: Mango D, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90.
