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849675-66-7,MFCD25976625
Catalog No.:AA00G89F

849675-66-7 | Hm30181

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
≥98%
in stock  
$203.00   $142.00
- +
10mg
99%
in stock  
$307.00   $215.00
- +
25mg
99%
in stock  
$504.00   $353.00
- +
50mg
99%
in stock  
$772.00   $540.00
- +
100mg
99%
in stock  
$1,093.00   $765.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00G89F
Chemical Name:
Hm30181
CAS Number:
849675-66-7
Molecular Formula:
C38H36N6O7
Molecular Weight:
688.7284
MDL Number:
MFCD25976625
SMILES:
COc1cc(c(cc1OC)NC(=O)c1cc(=O)c2c(o1)cccc2)c1nnn(n1)c1ccc(cc1)CCN1CCc2c(C1)cc(c(c2)OC)OC
Properties
Computed Properties
 
Complexity:
1220  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
51  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
11  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
5.8  

Literature

Title: Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography.

Journal: European journal of pharmacology 20121205

Title: Tolerability and pharmacokinetics of a new P-glycoprotein inhibitor, HM30181, in healthy Korean male volunteers: single- and multiple-dose randomized, placebo-controlled studies.

Journal: Clinical therapeutics 20120201

Title: Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel.

Journal: European journal of pharmacology 20100210

Title: Response of brain specific microenvironment to P-glycoprotein inhibitor: an important factor determining therapeutic effect of P-glycoprotein inhibitor on brain metastatic tumors.

Journal: International journal of oncology 20081001

Title: Characterization of human liver cytochrome P-450 enzymes involved in the O-demethylation of a new P-glycoprotein inhibitor HM-30181.

Journal: Journal of toxicology and environmental health. Part A 20070801

Title: Simultaneous determination of paclitaxel and a new P-glycoprotein inhibitor HM-30181 in rat plasma by liquid chromatography with tandem mass spectrometry.

Journal: Journal of separation science 20060301

Title: Metabolism of a new P-glycoprotein inhibitor HM-30181 in rats using liquid chromatography/electrospray mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Bauer F, et al. Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography. Eur J Pharmacol. 2012 Dec 5;696(1-3):18-27.

Title: Kim TE, et al. Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. Br J Clin Pharmacol. 2014 Sep;78(3):556-64.

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SDS
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Tags:849675-66-7 Molecular Formula|849675-66-7 MDL|849675-66-7 SMILES|849675-66-7 Hm30181
Catalog No.: AA00G89F
849675-66-7,MFCD25976625
849675-66-7 | Hm30181
Pack Size： 1mg
Purity： ≥98%
in stock
$53.00 $37.00
Pack Size： 5mg
Purity： ≥98%
in stock
$203.00 $142.00
Pack Size： 10mg
Purity： 99%
in stock
$307.00 $215.00
Pack Size： 25mg
Purity： 99%
in stock
$504.00 $353.00
Pack Size： 50mg
Purity： 99%
in stock
$772.00 $540.00
Pack Size： 100mg
Purity： 99%
in stock
$1,093.00 $765.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00G89F
Chemical Name: Hm30181
CAS Number: 849675-66-7
Molecular Formula: C38H36N6O7
Molecular Weight: 688.7284
MDL Number: MFCD25976625
SMILES: COc1cc(c(cc1OC)NC(=O)c1cc(=O)c2c(o1)cccc2)c1nnn(n1)c1ccc(cc1)CCN1CCc2c(C1)cc(c(c2)OC)OC
Properties
Complexity: 1220  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 51  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 11  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 5.8  
Literature fold

Title: Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography.

Journal: European journal of pharmacology20121205

Title: Tolerability and pharmacokinetics of a new P-glycoprotein inhibitor, HM30181, in healthy Korean male volunteers: single- and multiple-dose randomized, placebo-controlled studies.

Journal: Clinical therapeutics20120201

Title: Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel.

Journal: European journal of pharmacology20100210

Title: Response of brain specific microenvironment to P-glycoprotein inhibitor: an important factor determining therapeutic effect of P-glycoprotein inhibitor on brain metastatic tumors.

Journal: International journal of oncology20081001

Title: Characterization of human liver cytochrome P-450 enzymes involved in the O-demethylation of a new P-glycoprotein inhibitor HM-30181.

Journal: Journal of toxicology and environmental health. Part A20070801

Title: Simultaneous determination of paclitaxel and a new P-glycoprotein inhibitor HM-30181 in rat plasma by liquid chromatography with tandem mass spectrometry.

Journal: Journal of separation science20060301

Title: Metabolism of a new P-glycoprotein inhibitor HM-30181 in rats using liquid chromatography/electrospray mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20060101

Title: Bauer F, et al. Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography. Eur J Pharmacol. 2012 Dec 5;696(1-3):18-27.

Title: Kim TE, et al. Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. Br J Clin Pharmacol. 2014 Sep;78(3):556-64.

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