Home Other Building Blocks 923032-37-5
923032-37-5,MFCD18633256
Catalog No.:AA00GR9W

923032-37-5 | Refametinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$17.00   $12.00
- +
5mg
98+%
in stock  
$41.00   $29.00
- +
10mg
98+%
in stock  
$60.00   $42.00
- +
50mg
98+%
in stock  
$169.00   $118.00
- +
100mg
95%
in stock  
$311.00   $218.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GR9W
Chemical Name:
Refametinib
CAS Number:
923032-37-5
Molecular Formula:
C19H20F3IN2O5S
Molecular Weight:
572.3372
MDL Number:
MFCD18633256
SMILES:
OC[C@H](CC1(CC1)S(=O)(=O)Nc1c(OC)cc(c(c1Nc1ccc(cc1F)I)F)F)O
Properties
Computed Properties
 
Complexity:
711  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  
XLogP3:
2.8  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Multicenter phase I trial of the mitogen-activated protein kinase 1/2 inhibitor BAY 86-9766 in patients with advanced cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20130301

Title: MEK and the inhibitors: from bench to bedside.

Journal: Journal of hematology & oncology 20130101

Title: Induction of sodium/iodide symporter (NIS) expression and radioiodine uptake in non-thyroid cancer cells.

Journal: PloS one 20120101

Title: Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.

Journal: Science (New York, N.Y.) 20110415

Title: BRAF mutation-selective inhibition of thyroid cancer cells by the novel MEK inhibitor RDEA119 and genetic-potentiated synergism with the mTOR inhibitor temsirolimus.

Journal: International journal of cancer 20101215

Title: Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts.

Journal: BMC cancer 20100101

Title: RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer.

Journal: Cancer research 20090901

Title: Iverson C, et al. RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res. 2009 Sep 1;69(17):6839-47.

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SDS
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