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88899-56-3,MFCD00242671
Catalog No.:AA00GRQ7

88899-56-3 | BAFILOMYCIN B1

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Purity
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Price(USD)
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1mg
≥97%
in stock  
$203.00   $142.00
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5mg
≥97%
in stock  
$722.00   $505.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GRQ7
Chemical Name:
BAFILOMYCIN B1
CAS Number:
88899-56-3
Molecular Formula:
C44H65NO13
Molecular Weight:
815.9858
MDL Number:
MFCD00242671
SMILES:
CO[C@H]1/C=C/C=C(\C)/C[C@H](C)[C@H](O)[C@@H](/C=C(/C=C(/C(=O)O[C@@H]1[C@H]([C@H]([C@@H]([C@@]1(O)C[C@@H](OC(=O)/C=C/C(=O)NC2=C(O)CCC2=O)[C@@H]([C@H](O1)C(C)C)C)C)O)C)\OC)\C)C C44H65NO13
Properties
Computed Properties
 
Complexity:
1670  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Defined Bond Stereocenter Count:
5  
Heavy Atom Count:
58  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
12  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.9  

Literature

Title: Vacuolar H(+)-ATPase plays a key role in cell wall biosynthesis of Aspergillus niger.

Journal: Fungal genetics and biology : FG & B 20120401

Title: Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.

Journal: DNA research : an international journal for rapid publication of reports on genes and genomes 20101201

Title: Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in beta cells and delays neonatal remodeling of the endocrine pancreas.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080801

Title: Biosynthetic origin of the methoxyl extender unit in bafilomycin and concanamycin using stereospecifically labeled precursors.

Journal: The Journal of antibiotics 20070101

Title: The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 beta-cells.

Journal: Cell biology and toxicology 20060501

Title: Vesicular calcium transport shapes rapid acetylcholine secretion.

Journal: Journal of molecular neuroscience : MN 20060101

Title: Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A.

Journal: The Journal of antibiotics 20041001

Title: Transplacental exposure to bafilomycin disrupts pancreatic islet organogenesis and accelerates diabetes onset in NOD mice.

Journal: Journal of autoimmunity 20040601

Title: Intergeneric conjugal transfer of plasmid DNA from Escherichia coli to Kitasatospora setae, a bafilomycin B1 producer.

Journal: Archives of microbiology 20040401

Title: R176502, a new bafilolide metabolite with potent antiproliferative activity from a novel Micromonospora species.

Journal: The Journal of antibiotics 20031101

Title: Proteome analysis of Aspergillus nidulans reveals proteins associated with the response to the antibiotic concanamycin A, produced by Streptomyces species.

Journal: Molecular genetics and genomics : MGG 20020801

Title: Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes.

Journal: Biochemistry 20010306

Title: Bowman EJ, et al. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7972-6.

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