92564-34-6,MFCD00069285
Catalog No.:AA00GRQ8

92564-34-6 | HA-1004 DIHYDROCHLORIDE

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Purity
Availability
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1mg
1 week  
$480.00   $336.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GRQ8
Chemical Name:
HA-1004 DIHYDROCHLORIDE
CAS Number:
92564-34-6
Molecular Formula:
C12H16ClN5O2S
Molecular Weight:
329.8057
MDL Number:
MFCD00069285
SMILES:
NC(=NCCNS(=O)(=O)c1cccc2c1ccnc2)N.Cl
Properties
Computed Properties
 
Complexity:
441  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Lidocaine-induced apoptosis of gingival fibroblasts: participation of cAMP and PKC activity.

Journal: Cell biology international 20110801

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart.

Journal: The Journal of pharmacology and experimental therapeutics 20090901

Title: Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblasts.

Journal: Endocrine journal 20090101

Title: The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts.

Journal: British journal of pharmacology 20080901

Title: Differential involvement of 3', 5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos and tyrosine hydroxylase expression in the heart after naloxone induced morphine withdrawal.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070101

Title: Thyroid hormone-induced morphological differentiation and maturation of astrocytes involves activation of protein kinase A and ERK signalling pathway.

Journal: The European journal of neuroscience 20051001

Title: Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004.

Journal: Biochemical and biophysical research communications 20050909

Title: Involvement of 3',5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos expression and tyrosine hydroxylase levels during morphine withdrawal in the hypothalamic paraventricular nucleus and medulla oblongata catecholaminergic cell groups.

Journal: Journal of neurochemistry 20050101

Title: Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.

Journal: The Journal of physiology 20031201

Title: Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi.

Journal: The Biochemical journal 20031101

Title: Implication of the signal transduction pathways in the enhancement of noradrenaline turnover induced by morphine withdrawal in the heart.

Journal: European journal of pharmacology 20030620

Title: Inhibition of histamine H1 receptor downregulation by KT5823, a protein kinase G inhibitor.

Journal: Methods and findings in experimental and clinical pharmacology 20030601

Title: FK506 restores sensitivity of thymic lymphomas to calcium-mediated apoptosis and the inducible expression of Fas ligand.

Journal: Anticancer research 20030101

Title: Inhibition of protein kinase C but not protein kinase A attenuates morphine withdrawal excitation of rat hypothalamus-pituitary-adrenal axis.

Journal: European journal of pharmacology 20020927

Title: HA1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Ca2+-mediated apoptosis through a protein kinase A-independent mechanism.

Journal: International immunopharmacology 20020301

Title: The signalling pathway for BCG-induced interleukin-6 production in human bladder cancer cells.

Journal: Biochemical pharmacology 20020115

Title: cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization.

Journal: Neuron 20010927

Title: Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.

Journal: Circulation 20010731

Title: Inhibition of oxotremorine-induced desensitization of guinea-pig ileal longitudinal muscle in Ca2+-free conditions.

Journal: The Journal of pharmacy and pharmacology 20010201

Title: Heparin selectively inhibits the transcription of tissue-type plasminogen activator in primate arterial smooth muscle cells during mitogenesis.

Journal: The Journal of biological chemistry 19920215

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SDS
Tags:92564-34-6 Molecular Formula|92564-34-6 MDL|92564-34-6 SMILES|92564-34-6 HA-1004 DIHYDROCHLORIDE
Catalog No.: AA00GRQ8
92564-34-6,MFCD00069285
92564-34-6 | HA-1004 DIHYDROCHLORIDE
Pack Size: 1mg
Purity:
1 week
$480.00 $336.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00GRQ8
Chemical Name: HA-1004 DIHYDROCHLORIDE
CAS Number: 92564-34-6
Molecular Formula: C12H16ClN5O2S
Molecular Weight: 329.8057
MDL Number: MFCD00069285
SMILES: NC(=NCCNS(=O)(=O)c1cccc2c1ccnc2)N.Cl
Properties
Complexity: 441  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 21  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Lidocaine-induced apoptosis of gingival fibroblasts: participation of cAMP and PKC activity.

Journal: Cell biology international20110801

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart.

Journal: The Journal of pharmacology and experimental therapeutics20090901

Title: Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblasts.

Journal: Endocrine journal20090101

Title: The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts.

Journal: British journal of pharmacology20080901

Title: Differential involvement of 3', 5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos and tyrosine hydroxylase expression in the heart after naloxone induced morphine withdrawal.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20070101

Title: Thyroid hormone-induced morphological differentiation and maturation of astrocytes involves activation of protein kinase A and ERK signalling pathway.

Journal: The European journal of neuroscience20051001

Title: Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004.

Journal: Biochemical and biophysical research communications20050909

Title: Involvement of 3',5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos expression and tyrosine hydroxylase levels during morphine withdrawal in the hypothalamic paraventricular nucleus and medulla oblongata catecholaminergic cell groups.

Journal: Journal of neurochemistry20050101

Title: Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.

Journal: The Journal of physiology20031201

Title: Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi.

Journal: The Biochemical journal20031101

Title: Implication of the signal transduction pathways in the enhancement of noradrenaline turnover induced by morphine withdrawal in the heart.

Journal: European journal of pharmacology20030620

Title: Inhibition of histamine H1 receptor downregulation by KT5823, a protein kinase G inhibitor.

Journal: Methods and findings in experimental and clinical pharmacology20030601

Title: FK506 restores sensitivity of thymic lymphomas to calcium-mediated apoptosis and the inducible expression of Fas ligand.

Journal: Anticancer research20030101

Title: Inhibition of protein kinase C but not protein kinase A attenuates morphine withdrawal excitation of rat hypothalamus-pituitary-adrenal axis.

Journal: European journal of pharmacology20020927

Title: HA1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Ca2+-mediated apoptosis through a protein kinase A-independent mechanism.

Journal: International immunopharmacology20020301

Title: The signalling pathway for BCG-induced interleukin-6 production in human bladder cancer cells.

Journal: Biochemical pharmacology20020115

Title: cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization.

Journal: Neuron20010927

Title: Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.

Journal: Circulation20010731

Title: Inhibition of oxotremorine-induced desensitization of guinea-pig ileal longitudinal muscle in Ca2+-free conditions.

Journal: The Journal of pharmacy and pharmacology20010201

Title: Heparin selectively inhibits the transcription of tissue-type plasminogen activator in primate arterial smooth muscle cells during mitogenesis.

Journal: The Journal of biological chemistry19920215

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