Home Fluorides 93076-89-2
93076-89-2,MFCD00055114
Catalog No.:AA00GRR0

93076-89-2 | 6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

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1mg
≥98%
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$53.00   $37.00
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5mg
≥98%
in stock  
$129.00   $90.00
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10mg
≥98%
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$225.00   $157.00
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50mg
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$958.00   $670.00
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GRR0
Chemical Name:
6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
CAS Number:
93076-89-2
Molecular Formula:
C27H26FN3OS
Molecular Weight:
459.5782
MDL Number:
MFCD00055114
SMILES:
Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccccc1
Properties
Computed Properties
 
Complexity:
868  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
5.1  

Literature

Title: Diacylglycerol kinase inhibitor R59022-induced autophagy and apoptosis in the neuronal cell line NG108-15.

Journal: Archives of biochemistry and biophysics 20110515

Title: Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species.

Journal: Free radical research 20110301

Title: A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.

Journal: Molecular medicine (Cambridge, Mass.) 20110101

Title: Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100501

Title: Insulin action on polyunsaturated phosphatidic acid formation in rat brain: an 'in vitro' model with synaptic endings from cerebral cortex and hippocampus.

Journal: Neurochemical research 20090701

Title: Phospholipase C signaling involvement in macrotubule assembly and activation of the mechanism regulating protoplast volume in plasmolyzed root cells of Triticum turgidum.

Journal: The New phytologist 20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells.

Journal: Biochemical and biophysical research communications 20070817

Title: Nitric oxide is critical for inducing phosphatidic acid accumulation in xylanase-elicited tomato cells.

Journal: The Journal of biological chemistry 20070720

Title: Calcium signaling via phospholipase C is essential for proline accumulation upon ionic but not nonionic hyperosmotic stresses in Arabidopsis.

Journal: Plant physiology 20070501

Title: Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases (DGKs), displays unique biochemical features and saturates at low substrate concentration: the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro and alters plant growth and development.

Journal: The Journal of biological chemistry 20051014

Title: Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs).

Journal: Journal of cellular biochemistry 20050301

Title: Foreign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022.

Journal: The American journal of pathology 20030901

Title: Zona pellucida induces activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa.

Journal: Biology of reproduction 20030301

Title: Activation of phospholipases C and D is an early response to a cold exposure in Arabidopsis suspension cells.

Journal: Plant physiology 20021001

Title: Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.

Journal: Anti-cancer drugs 20020801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: PLD pathway involved in carbachol-induced Cl- secretion: possible role of TNF-alpha.

Journal: American journal of physiology. Cell physiology 20010401

Title: de Chaffoy de Courcelles DC, et al. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. J Biol Chem. 1985 Dec 15;260(29):15762-70.

Title: Nunn DL, et al. A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem J. 1987 May 1;243(3):809-13.

Title: Jones JA, et al. Influence of phorbol esters, and diacylglycerol kinase and lipase inhibitors on noradrenalinerelease and phosphoinositide hydrolysis in chromaffin cells. Br J Pharmacol. 1990 Nov;101(3):521-6.

Title: Boroda S, et al. Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists. Biochem Pharmacol. 2017 Jan 1;123:29-39.

Title: Stewart CM, et al. A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells. Viruses. 2019 Mar 1;11(3). pii: E206.

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Tags:93076-89-2 Molecular Formula|93076-89-2 MDL|93076-89-2 SMILES|93076-89-2 6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one