905586-69-8,MFCD16621127
Catalog No.:AA00GRS4

905586-69-8 | Az 960

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$168.00   $117.00
- +
5mg
≥98%
in stock  
$578.00   $404.00
- +
10mg
≥98%
in stock  
$909.00   $636.00
- +
25mg
98% by HPLC
in stock  
$1,944.00   $1,361.00
- +
50mg
98%
in stock  
$2,854.00   $1,998.00
- +
100mg
98%
in stock  
$5,091.00   $3,564.00
- +
500mg
98% by HPLC
in stock  
$17,974.00   $12,582.00
- +
1000mg
98% by HPLC
in stock  
$28,724.00   $20,107.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GRS4
Chemical Name:
Az 960
CAS Number:
905586-69-8
Molecular Formula:
C18H16F2N6
Molecular Weight:
354.3566
MDL Number:
MFCD16621127
SMILES:
N#Cc1cc(F)c(nc1N[C@H](c1ccc(cc1)F)C)Nc1n[nH]c(c1)C
Properties
Computed Properties
 
Complexity:
503  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
4.4  

Downstream Synthesis Route
905587-21-5    66399-30-2   
AZ960 

[1]Patent:WO2006/82392,2006,A1.Locationinpatent:Page/Pagecolumn86

[1]Locationinpatent:schemeortableWang,Tao;Ioannidis,Stephanos;Almeida,Lynsie;Block,MichaelH.;Davies,AudreyM.;Lamb,MichelleL.;Scott,DavidA.;Su,Mei;Zhang,Hai-Jun;Alimzhanov,Marat;Bebernitz,Geraldine;Bell,Kirsten;Zinda,Michael[BioorganicandMedicinalChemistryLetters,2011,vol.21,#10,p.2958-2961]

Literature

Title: Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia.

Journal: International journal of cancer 20111115

Title: In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells.

Journal: Molecular cancer therapeutics 20101201

Title: Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.

Journal: The Journal of biological chemistry 20081121

Title: Ikezoe T, et al. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. Int J Cancer. 2011 Nov 15;129(10):2512-21.

Title: Gozgit JM, et al. Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. J Biol Chem. 2008 Nov 21;283(47):32334-43.

Title: Yang J, et al. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010 Dec;9(12):3386-95.

Title: Valenciano AL, et al. Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor. Bioorg Med Chem. 2016 Oct 1;24(19):4647-51.

Quotation Request
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Additional Info:
SDS
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Tags:905586-69-8 Molecular Formula|905586-69-8 MDL|905586-69-8 SMILES|905586-69-8 Az 960
Catalog No.: AA00GRS4
905586-69-8,MFCD16621127
905586-69-8 | Az 960
Pack Size: 1mg
Purity: ≥98%
in stock
$168.00 $117.00
Pack Size: 5mg
Purity: ≥98%
in stock
$578.00 $404.00
Pack Size: 10mg
Purity: ≥98%
in stock
$909.00 $636.00
Pack Size: 25mg
Purity: 98% by HPLC
in stock
$1,944.00 $1,361.00
Pack Size: 50mg
Purity: 98%
in stock
$2,854.00 $1,998.00
Pack Size: 100mg
Purity: 98%
in stock
$5,091.00 $3,564.00
Pack Size: 500mg
Purity: 98% by HPLC
in stock
$17,974.00 $12,582.00
Pack Size: 1000mg
Purity: 98% by HPLC
in stock
$28,724.00 $20,107.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00GRS4
Chemical Name: Az 960
CAS Number: 905586-69-8
Molecular Formula: C18H16F2N6
Molecular Weight: 354.3566
MDL Number: MFCD16621127
SMILES: N#Cc1cc(F)c(nc1N[C@H](c1ccc(cc1)F)C)Nc1n[nH]c(c1)C
Properties
Complexity: 503  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 5  
XLogP3: 4.4  
Downstream Synthesis Route
905587-21-5    66399-30-2   
AZ960 

[1]Patent:WO2006/82392,2006,A1.Locationinpatent:Page/Pagecolumn86

1419073-74-7    905586-69-8 

[1]Locationinpatent:schemeortableWang,Tao;Ioannidis,Stephanos;Almeida,Lynsie;Block,MichaelH.;Davies,AudreyM.;Lamb,MichelleL.;Scott,DavidA.;Su,Mei;Zhang,Hai-Jun;Alimzhanov,Marat;Bebernitz,Geraldine;Bell,Kirsten;Zinda,Michael[BioorganicandMedicinalChemistryLetters,2011,vol.21,#10,p.2958-2961]

Literature fold

Title: Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia.

Journal: International journal of cancer20111115

Title: In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters20110515

Title: AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells.

Journal: Molecular cancer therapeutics20101201

Title: Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.

Journal: The Journal of biological chemistry20081121

Title: Ikezoe T, et al. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. Int J Cancer. 2011 Nov 15;129(10):2512-21.

Title: Gozgit JM, et al. Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. J Biol Chem. 2008 Nov 21;283(47):32334-43.

Title: Yang J, et al. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010 Dec;9(12):3386-95.

Title: Valenciano AL, et al. Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor. Bioorg Med Chem. 2016 Oct 1;24(19):4647-51.

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