Title: γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement.
Journal: Bioorganic & medicinal chemistry letters 20120801
Title: Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats.
Journal: Behavioural brain research 20110912
Title: Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers.
Journal: The Journal of pharmacy and pharmacology 20110901
Title: Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.
Journal: European journal of pharmacology 20110511
Title: Combined effects of blood serum as a source of endogenous β-adrenoceptor-sensitizing agent and its analogues histidine, tryptophan, tyrosine, mildronat, and preductal.
Journal: Bulletin of experimental biology and medicine 20110501
Title: Correction of glycaemia and GLUT1 level by mildronate in rat streptozotocin diabetes mellitus model.
Journal: Cell biochemistry and function 20110101
Title: Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
Journal: Pharmacological reports : PR 20110101
Title: [Oxidative homeostasis and functional parameters of rats at high altitudes with alpha-lipoic acid correction].
Journal: Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine 20110101
Title: Mildronate as a regulator of protein expression in a rat model of Parkinson's disease.
Journal: Medicina (Kaunas, Lithuania) 20110101
Title: [The influence of mildronate on peripheral neuropathy and some characteristics of glucose and lipid metabolism in rat streptozotocin-induced diabetes mellitus model].
Journal: Biomeditsinskaia khimiia 20110101
Title: Mildronate exerts acute anticonvulsant and antihypnotic effects.
Journal: Behavioural pharmacology 20100901
Title: Crystal structure of human gamma-butyrobetaine hydroxylase.
Journal: Biochemical and biophysical research communications 20100806
Title: The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats.
Journal: European journal of pharmacology 20100610
Title: Determination of mildronate by LC-MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100215
Title: Neuroprotective properties of mildronate, a mitochondria-targeted small molecule.
Journal: Neuroscience letters 20100212
Title: Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats.
Journal: Chemotherapy 20100101
Title: Neuroprotective properties of mildronate, a small molecule, in a rat model of Parkinson's disease.
Journal: International journal of molecular sciences 20100101
Title: [Optimization of energy metabolism in patients with chronic heart failure].
Journal: Likars'ka sprava 20100101
Title: Effects of long-term mildronate treatment on cardiac and liver functions in rats.
Journal: Basic & clinical pharmacology & toxicology 20091201
Title: Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism.
Journal: Journal of enzyme inhibition and medicinal chemistry 20091201
Title: Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
Journal: Cardiovascular drugs and therapy 20090801
Title: Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
Journal: British journal of pharmacology 20090801
Title: The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090201
Title: Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice.
Journal: Pharmacology 20090101
Title: [Clinical condition of patients with persistent form of atrial fibrillation before and after cardioversion].
Journal: Klinicheskaia meditsina 20090101
Title: Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial function.
Journal: Pharmacological reports : PR 20090101
Title: Application of hydrophilic interaction chromatography for simultaneous separation of six impurities of mildronate substance.
Journal: Journal of pharmaceutical and biomedical analysis 20081104
Title: Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.
Journal: Life sciences 20081024
Title: Effect of inhibiting carnitine biosynthesis on male rat sexual performance.
Journal: Physiology & behavior 20081020
Title: Interaction of mildronate with the mitochondrial carnitine/acylcarnitine transport protein.
Journal: Journal of biochemical and molecular toxicology 20080201
Title: Mitochondria as the target for mildronate's protective effects in azidothymidine (AZT)-induced toxicity of isolated rat liver mitochondria.
Journal: Cell biochemistry and function 20080101
Title: [Mildronate effects on oxidant stress in type 2 diabetic patients with diabetic peripheral (sensomotor) neuropathy].
Journal: Terapevticheskii arkhiv 20080101
Title: Determination of mildronate in human plasma and urine by liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601
Title: [Comparative trial of efficacy of trimethasidine MB and 3-(2,2,2-trimethylhydrasine) propionate dihydrate in chronic heart failure].
Journal: Terapevticheskii arkhiv 20070101
Title: [Derangements of contractility of left ventricular myocardium in patients subjected to coronary bypass surgery. Methods of their correction].
Journal: Kardiologiia 20070101
Title: [The use of mildronate in combined therapy of postinfarction chronic heart failure in patients with type 2 diabetes mellitus].
Journal: Klinicheskaia meditsina 20070101
Title: [The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohidrate metabolism in the hyperthyroid and hypothyroid rats].
Journal: Biomeditsinskaia khimiia 20070101
Title: Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction.
Journal: Journal of cardiovascular pharmacology 20061201
Title: Protection of azidothymidine-induced cardiopathology in mice by mildronate, a mitochondria-targeted drug.
Journal: Basic & clinical pharmacology & toxicology 20061001
Title: [Change of concentration of L-carnitine in blood and other tissues in rats on a background of the alcohol intake and influence of mildronate on its level].
Journal: Georgian medical news 20060801
Title: [Change of concentration endothelin-1 in rats on a background of alcohol and /or mildronate treatment].
Journal: Georgian medical news 20060601
Title: Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).
Journal: Circulation 20060227
Title: [Effects of metabolic triad (25% polarizing solution, mildronat, preductal MR) in acute myocardial infarction].
Journal: Georgian medical news 20060201
Title: [Protective effects of the regulators of energy metabolism and essentiale in case of nitrite intoxication].
Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia 20060101
Title: [Effect of cytoprotection on the oxidative processes and endothelial function in elderly patients with ischemic heart disease].
Journal: Advances in gerontology = Uspekhi gerontologii 20060101
Title: Carnitine depletion in rat pups from mothers given mildronate: a model of carnitine deficiency in late fetal and neonatal life.
Journal: Life sciences 20051028
Title: Mildronate: an antiischemic drug for neurological indications.
Journal: CNS drug reviews 20050101
Title: Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate.
Journal: European journal of pharmacology 20040708
Title: Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat.
Journal: Molecular and cellular biochemistry 20040301
Title: [Biochemical mechanisms of mildronate action during ischemic stress].
Journal: Likars'ka sprava 20040301
Title: Effects of gamma-butyrobetaine and mildronate on nitric oxide production in lipopolysaccharide-treated rats.
Journal: Basic & clinical pharmacology & toxicology 20040101
Title: [Impaired blood coagulative properties in the early postresuscitation period and their prevention].
Journal: Anesteziologiia i reanimatologiia 20040101
Title: Mechanisms of liver steatosis in rats with systemic carnitine deficiency due to treatment with trimethylhydraziniumpropionate.
Journal: Journal of lipid research 20030101
Title: [Antioxidant activity of mildronate and L-carnitine in the treatment of patients with cerebrovascular diseases].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20030101
Title: [The use of fatty acid beta-oxidation inhibitor mildronate as monotherapy or in combination with atenolol in patients with left ventricular dysfunction after myocardial infarction].
Journal: Kardiologiia 20030101
Title: The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure.
Journal: Herz 20021101
Title: Mildronate: cardioprotective action through carnitine-lowering effect.
Journal: Trends in cardiovascular medicine 20020801
Title: [The role of endogenous modulators of chemoreactivity in the regulation of coronary blood flow].
Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020701
Title: [Anti-atherosclerotic action of mildronate in experiment].
Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia 20020101
Title: [The study and comparative evaluation of the actoprotective activity of ATF-LONG in experiment].
Journal: Likars'ka sprava 20020101
Title: Development and characterization of an animal model of carnitine deficiency.
Journal: European journal of biochemistry 20010301
Title: [Isoptin in the therapy of supraventricular arrhythmia in patients with diabetes mellitus, non-insulin dependent, concurrent with ischemic heart disease].
Journal: Likars'ka sprava 20010101
Title: Effect of 3-(2,2,2-trimethylhydrazinium) propionate, gamma-butyrobetaine hydroxylase inhibitor, on isoproterenol-induced mitochondrial dysfunction.
Journal: Research communications in chemical pathology and pharmacology 19890401
Title: [Effect of DL-carnitine and gamma-butyrobetaine hydroxylase inhibitor 3-(2,2,2-trimethylhydrazinium) propionate on isoproterenol-induced changes in the metabolism of the rat myocardium].
Journal: Voprosy meditsinskoi khimii 19880101
Title: Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780.
Title: Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25.