Title: Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
Journal: Journal of medicinal chemistry 20120322
Title: Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E₂ synthase-1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: Trisubstituted ureas as potent and selective mPGES-1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: Microsomal prostaglandin e synthase-1 in rheumatic diseases.
Journal: Frontiers in pharmacology 20100101
Title: Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20091015
Title: MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
Journal: The Journal of pharmacology and experimental therapeutics 20080501
Title: Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20071215
Title: Xu D et al. MF63 -(6-chloro-1H-phenanthro[9,10-dimidazol-2-yl)-isophthalonitrile, a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J Pharmacol Exp Ther. 2008 Sep;326(3):754-6
Title: Coté B et al. Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20.
Title: Baragatti B, Coceani F.,Dual, constrictor-to-dilator, response of the mouse ductus arteriosus to the microsomal prostaglandin E synthase-1 inhibitor, 2-(6-chloro-1H-phenanthro[9,10dimidazole- 2-yl)isophthalonitrile.,Neonatology. 2011;100(2):139-46. Epub
Title: Giroux A, et al. Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.,Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41. Epub 2009 Aug 28.
Title: Xu D, L,et al. MF63 -(6-chloro-1H-phenanthro[9,10-dimidazol-2-yl)-isophthalonitrile, a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.,J Pharmacol Exp Ther. 2008 Sep;326(3):75
