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862507-23-1,MFCD22572532
Catalog No.:AA00GU1B

862507-23-1 | Ly2228820

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$12.00   $8.00
- +
5mg
98+%
in stock  
$26.00   $18.00
- +
10mg
98+%
in stock  
$38.00   $27.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GU1B
Chemical Name:
Ly2228820
CAS Number:
862507-23-1
Molecular Formula:
C26H37FN6O6S2
Molecular Weight:
612.7370
MDL Number:
MFCD22572532
SMILES:
CS(=O)(=O)O.CS(=O)(=O)O.Fc1ccc(cc1)c1nc([nH]c1c1ccc2c(n1)n(CC(C)(C)C)c(n2)N)C(C)(C)C
Properties
Computed Properties
 
Complexity:
701  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  

Literature

Title: Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity.

Journal: Molecular cancer therapeutics 20140201

Title: p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.

Journal: British journal of haematology 20080501

Title: Mader M, et al. Imidazolyl benzimidazoles and imidazo,5-bpyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties. Bioorg Med Chem Lett, 2008, 18(1), 179-183.

Title: Ishitsuka K, et al. p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br J Haematol, 2008, 141(5), 598-606.

Title: Campbell RM, et al. Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity. Mol Cancer Ther. 2014 Feb;13(2):364-74.

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SDS
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Tags:862507-23-1 Molecular Formula|862507-23-1 MDL|862507-23-1 SMILES|862507-23-1 Ly2228820
Catalog No.: AA00GU1B
862507-23-1,MFCD22572532
862507-23-1 | Ly2228820
Pack Size： 1mg
Purity： 98+%
in stock
$12.00 $8.00
Pack Size： 5mg
Purity： 98+%
in stock
$26.00 $18.00
Pack Size： 10mg
Purity： 98+%
in stock
$38.00 $27.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00GU1B
Chemical Name: Ly2228820
CAS Number: 862507-23-1
Molecular Formula: C26H37FN6O6S2
Molecular Weight: 612.7370
MDL Number: MFCD22572532
SMILES: CS(=O)(=O)O.CS(=O)(=O)O.Fc1ccc(cc1)c1nc([nH]c1c1ccc2c(n1)n(CC(C)(C)C)c(n2)N)C(C)(C)C
Properties
Complexity: 701  
Covalently-Bonded Unit Count: 3  
Heavy Atom Count: 41  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 4  
Rotatable Bond Count: 5  
Literature fold

Title: Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity.

Journal: Molecular cancer therapeutics20140201

Title: p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.

Journal: British journal of haematology20080501

Title: Mader M, et al. Imidazolyl benzimidazoles and imidazo,5-bpyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties. Bioorg Med Chem Lett, 2008, 18(1), 179-183.

Title: Ishitsuka K, et al. p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br J Haematol, 2008, 141(5), 598-606.

Title: Campbell RM, et al. Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity. Mol Cancer Ther. 2014 Feb;13(2):364-74.

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